Radiation myelopathy / / Timothy E. Schultheiss

• Record Nr.: UNINA9910735387803321
• Autore: Schultheiss Timothy E.
• Pubbl/distr/stampa: Cham, Switzerland : , : Springer, , [2022]; ©2022
• ISBN: 9783030946586; 9783030946579
• Descrizione fisica: 1 online resource (260 pages) : illustrations
• Disciplina: 616.9940642
• Soggetti: Cancer - Radiotherapy - Complications; Spinal cord - Diseases; Cancer - Radiotherapy
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Preface -- Contents -- About the Author -- Abbreviations -- List of Figures -- List of Tables -- 1: History and the Search for the Tolerance Dose -- 1.1 Early Clinical Reports: How We Arrived at the 45-Gy Tolerance Dose -- 1.2 The Advent of New Technologies -- 1.3 Hypofractionation -- 1.4 The Spaghetti Plot: Not Culinary Intrigue, But Rather a Watershed in Radiobiology -- 1.5 Pathogenesis and Treatment -- References -- 2: Pathology and Pathogenesis -- 2.1 Some Spinal Cord Anatomy -- 2.2 Pathology -- 2.3 Pathogenesis -- 2.3.1 Cervical and Thoracic Levels -- 2.3.2 Lumbar Cord -- 2.3.3 Apoptosis -- 2.3.4 BNCT Studies -- 2.3.5 Roles of Cytokines -- 2.4 Traumatic Injury, Inflammation, and Covid-19 -- 2.5 Conclusion -- References -- 3: Statistics of Dose Response -- 3.1 Experimental Design -- 3.2 Experimental Data -- 3.2.1 Separation -- 3.2.2 More on Extreme Values -- 3.3 Analyzing Dose-Response Data -- 3.3.1 The Dose-Response Function -- 3.3.2 Collinearity -- 3.4 Fitting Models -- 3.4.1 Maximum Likelihood Estimation -- 3.4.2 Model Assessment -- 3.4.3 Degrees of Freedom -- 3.4.4 Confidence Intervals and Joint Confidence Regions -- 3.4.5 Examination of Residuals -- 3.5 Factors Other than Dose -- 3.5.1 Odds Ratio and Dose Modifying Factor -- 3.5.2 Exact Interval for Proportion: ; Graphical Presentation of the Data -- References -- 4: Radiation Myelopathy in Conventional Treatments -- 4.1 Relevant Aspects of Anatomy of the Spinal Cord by Level -- 4.2 Appearance of Symptoms -- 4.3 Dose Response by Level of Cord -- 4.4 Dose Limits -- 4.5 Radiation Myelopathy in Stereotactic Radiosurgery -- 4.6 Other Altered Fractionation Schedules -- References -- 5: Experimental Studies on Rodents -- 5.1 Mouse Studies -- 5.2 Rat Studies -- 5.3 Dose Modifying Factors (DMF) -- 5.4 Fractionation Studies in the Rat Up to 1990.; 5.4.1 Transition from the Power-Law Model to the LQ Model -- 5.4.2 Studies from van der Kogel -- 5.4.3 The Fe-Plot -- 5.4.4 Altered Fractionation and Top-Up Experiments -- 5.4.5 Additional Ang Studies -- 5.5 Dose Response After 1990 -- 5.6 Relative Biological Effectiveness (RBE) -- 5.6.1 Neutrons -- 5.6.2 Leith et al. Charged Particles -- 5.6.3 Carbon Ions -- 5.6.4 Protons -- 5.7 In Closing -- References -- 6: Volume Effect Studies in Rodents -- References -- 7: Long-Term Repair and Retreatment, Treatment of Immature Animals -- 7.1 Retreatment -- 7.1.1 The Dose-Repaired/Recovered Model -- 7.1.2 The Volume-Repaired Model of Retreatment Response -- 7.1.3 Human Retreatment -- 7.2 RM in Immature Humans and Animals -- References -- 8: Experimental Studies on Large Animals -- 8.1 Rhesus Monkeys -- 8.2 Pigs -- 8.3 Beagles -- 8.4 Fractionation -- References -- 9: Multispecies Dose-Response Model -- 9.1 Biostatistical Models -- 9.2 The Data -- 9.3 Results of Large Animal Data Analysis -- References -- Epilogue -- Chapter 1 -- Chapter 2 -- Chapter 3 -- Chapter 4 -- Chapter 5 -- Chapter 6 -- Chapter 7 -- Chapter 8 -- Chapter 9 -- Appendix: Medico-Legal Issues -- Basic Elements of Medical Malpractice -- Duty of Care -- Harm -- Causation -- Malpractice Related to Product Liability -- The Expert Witness -- Potential Responsibilities -- American College of Radiology (ACR) Guidelines -- American Association of Physicists in Medicine and the ACR for Medical Physicists -- Specific Issues in Radiation Oncology -- Quality Assurance (QA) in Treatment Planning and Delivery -- Outdated Treatment Techniques -- Literature Reports of Misdiagnosis -- Misdiagnosis I -- Misdiagnosis II -- Index.