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Record Nr. |
UNINA9910137201103321 |
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Autore |
Robert W. Burgess |
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Titolo |
Mechanisms of neural circuit formation / / Joshua A. Weiner, Robert W. Burgess, James Jontes [editors] |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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Switzerland : , : Frontiers Media SA, , 2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (179 pages) : illustrations; digital, PDF file(s) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Neuroscience |
Human Anatomy & Physiology |
Health & Biological Sciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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The formation of the proper pattern of neuronal circuits during development is critical for the normal function of the vertebrate brain and for the survival of the organism. Circuit tracing studies spanning the past 100 years have revealed the beauty and exquisite intricacy of this pattern, which represents the most complex biological system known. In humans, aberrant circuit formation is a likely underlying cause of a wide variety of birth defects and neurological disorders, including autism, intellectual disability, and schizophrenia. Furthermore, future therapeutic approaches to restoring the function of damaged neural circuits will require a better understanding of the developmental constraints under which those circuits were originally assembled. For these reasons, elucidating the molecular mechanisms of neural circuit formation is a major goal of neurobiology today.Substantial progress towards this goal has been made over the past decade, and the pace of research in the field continues to accelerate with the development of novel molecular techniques and a wider variety of genetic model systems, including zebrafish and nematodes in addition to fruit flies and mice. The aim of this Research Topic is to bring together the many strands of research that shed light on the |
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mechanisms driving neural circuit formation: studies of the differentiation of distinct neuronal subtypes; the formation of dendritic arbors and the elaboration of postsynaptic spines; the pathfinding, targeting, and branching of axons; the proper apposition of specific pre- and post-synaptic terminals; the emerging role of glial cells in facilitating synaptogenesis and synapse elimination; and the mutations behind the aberrant circuitry that leads to neurological disorders. We seek to highlight not only newly identified molecular mechanisms, but also technical advances that have allowed progress in the field to grow exponentially, including novel imaging techniques and the proliferation of large-scale “-omics” studies. We hope that this Research Topic will provide a forum for top researchers in the field to present new data, formulate novel hypotheses and models, and critically review recent progress in each step of neural circuit formation. |
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2. |
Record Nr. |
UNINA9910731483703321 |
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Autore |
Mesko Marek |
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Titolo |
Alexios I Komnenos in the Balkans, 1081–1095 / / by Marek Meško |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Palgrave Macmillan, , 2023 |
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ISBN |
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Edizione |
[1st ed. 2023.] |
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Descrizione fisica |
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1 online resource (437 pages) |
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Collana |
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New Approaches to Byzantine History and Culture, , 2730-9371 |
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Disciplina |
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Soggetti |
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Europe - History - 476-1492 |
Military history |
Russia - History |
Europe, Eastern - History |
Soviet Union - History |
History of Medieval Europe |
Military History |
Russian, Soviet, and East European History |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Introduction -- 2. Army and Navy in Eleventh-Century Byzantium -- 3. Alexios I Komnenos -- 4. War against the Normans (1081–1085) -- 5. War against the Pechenegs (1083–1091) -- 6. Kuman Invasion (1095) -- 7. Synthesis -- 8. Conclusion. . |
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Sommario/riassunto |
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This book provides a new military history of Byzantine emperor Alexios I Komnenos's campaigns in the Balkans, during the first fourteen years of his rule. While the tactics and manoeuvres Alexios used against Robert Guiscard's Normans are relatively well-known, his strategy in dealing with Pecheneg and Cuman adversaries in the region has received less attention in historical scholarship. This book provides a much-need synthesis of these three closely linked campaigns – often treated as discrete events – revealing a surprising coherence in Alexios' response, and explores the position of Byzantium's army and navy on the eve of the First Crusade. Marek Meško is an assistant professor at the University of Hradec Kralove, Institute of History, Czech Republic. . |
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