Aareal Bank AG MarketLine Company Profile

• Record Nr.: UNINA9910718358003321
• Pubbl/distr/stampa: MarketLine, a Progressive Digital Media business
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Periodico

PI PAC : pressurized intraperitoneal aerosol chemotherapy : cancer under pressure / / edited by Marc A. Reymond, Wiebke Solass

• Record Nr.: UNINA9910788811003321
• Pubbl/distr/stampa: Berlin, [Germany] ; ; Boston, [Massachusetts] : , : Walter de Gruyter GmbH, , 2014; ©2014
• ISBN: 3-11-036661-4; 3-11-038636-4
• Descrizione fisica: 1 online resource (252 p.)
• Disciplina: 616.99/4061
• Soggetti: Antineoplastic agents; Aerosol
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Front matter -- Preface -- Acknowledgments -- Contents -- 1. Introduction / Reymond, M. A. -- 2. Peritoneal carcinomatosis: a neglected disease / Reymond, M. A. -- 3. Normal and diseased peritoneum / Solass, W. / Reymond, M. A. -- 4. Diagnosis and staging of peritoneal carcinomatosis / Solass, W. / Reymond, M. A. -- 5. Therapy of peritoneal carcinomatosis / Demtröder, C. / Giger-Pabst, U. / Solass, W. / Reymond, M. A. -- 6. Assessing tumor response in peritoneal carcinomatosis / Solass, W. / Reymond, M. A. -- 7. Principle ; of therapeutic capnoperitoneum / Reymond, M. A. / Hu, B. / Garcia, A. / Reck, T. / Köckerling, F. / Hess, J. / Morel, P. -- 8. PIPAC Technology / Solass, W. / Hetzel, A. / Schwarz, T. / Nadiradze, G. / Sagynaliev, E. / Reymond, M. A. -- 9. Preclinical experiments / Reymond, M. A. / Tannapfel, A. / Schneider, C. / Scheidbach, H. / Köver, S. / Jung, A. / Reck, T. / Lippert, H. / Köckerling, F. -- 10. First PIPAC in-human application / Solass, W. / Kerb, R. / Mürdter, T. / Giger-Pabst, U. / Strumberg, D. / Tempfer, C. / Zieren, J. / Schwab, M. / Reymond, M. A. -- 11. Renal and liver toxicities / Blanco, A. / Giger-Pabst, U. / Solass, W. / Zieren, J. / Reymond, M. A. -- 12. PIPAC in ovarian cancer / Tempfer, C. B. / Celik, I. / Solass, W. / Buerkle, B. / Giger-Pabst, U. / Zieren, J. / Strumberg, D. / Reymond, M. A. -- 13. PIPAC in gastric cancer / Nadiradze, G. / Solass, W. / Zieren, J. / Strumberg, D. / Reymond, M. A. / Giger-Pabst, U. -- 14. PIPAC in colorectal cancer / Giger-Pabst, U. / Solass, W. / Demtröder, C. / Strumberg, D. / Zieren, J. / Reymond, M. A. -- 15. PIPAC in mesothelioma / Solass, W. / Giger-Pabst, U. / Demtröder, C. / Strumberg, D. / Zieren, J. / Reymond, M. A. -- 16. Quality of Life after PIPAC / Odendahl, K. / Solass, W. / Demtröder, C. / Giger-Pabst, U. / Tempfer, C. / Strumberg, D. / Münker, A. / Reymond, M. A. -- 17. PIPAC and HIPEC / Reymond, M. A. -- 18. Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) / Jonscher, N. / Hummels, M. / Giger-Pabst, U. / Karljalainen, E. / Zieren, J. / Büchner, N. / Reymond, M. A. / Beshay, M. -- 19. Future applications of therapeutic capnoperitoneum / Khalili-Harbi, N. / Herbette, A. / Solass, W. / Giger-Pabst, U. / Engin, E. / Giese, A. / Dutreix, M. / Reymond, M. A. -- 20. Occupational health and safety aspects / Solass, W. / Giger-Pabst, U. / Zieren, J. / Reymond, M. A. -- 21. PIPAC: Risks and dangers / Giger-Pabst, U. / Reymond, M. A. -- 22. Outlook / Reymond, M. A. -- 23. How to start a PIPAC program at your own institution? / Giger-Pabst, U. / Reymond, M. A. -- 24. Training and Standard Operating Procedures / Giger-Pabst, U. / Reymond, M. A. -- Index
• Sommario/riassunto: Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer. However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to ; conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low. In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations.

All Sides to an Oval : Properties, Parameters, and Borromini's Mysterious Construction / / by Angelo Alessandro Mazzotti

• Record Nr.: UNINA9910254289903321
• Autore: Mazzotti Angelo Alessandro
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
• ISBN: 9783319393759
• Edizione: [1st ed. 2017.]
• Descrizione fisica: 1 online resource (X, 160 p. 129 illus., 126 illus. in color.)
• Disciplina: 516
• Soggetti: Geometry; Mathematics; Mathematics in Art and Architecture
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Introduction -- Properties of a polycentric oval.-F -- Ruler/Compass constructions of simple ovals -- Ovals with given symmetry axis lines -- Ovals with unknown axis lines.-Inscribing and circumscribing ovals – The frame problem -- The stadium problem and the running track -- Parameter formulas for simple ovals and applications -- Parameter formulas for simple ovals -- Limitations for the frame problem -- Measuring a four-centre oval -- Optimisation problems for ovals -- Ovals with 4n centres -- Remarkable four-centre ovals .-Appendix.-References.-Acknowledgements. .
• Sommario/riassunto: This is the only book dedicated to the Geometry of Polycentric Ovals. It includes problem solving constructions and mathematical formulas. For ; anyone interested in drawing or recognizing an oval, this book gives all the necessary construction and calculation tools. More than 30 basic construction problems are solved, with references to Geogebra animation videos, plus the solution to the Frame Problem and solutions to the Stadium Problem. A chapter (co-written with Margherita Caputo) is dedicated to totally new hypotheses on the project of Borromini’s oval dome of the church of San Carlo alle Quattro Fontane in Rome. Another one presents the case study of the Colosseum as an example of ovals with eight centres. The book is unique and new in its kind: original contributions add up to about 60% of the whole book, the rest being taken from published literature (and mostly from other work by the same author). The primary audience is: architects, graphic designers, industrial designers, architecture historians, civil engineers; moreover, the systematic way in which the book is organised could make it a companion to a textbook on descriptive geometry or on CAD.