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Record Nr. |
UNINA9910717369903321 |
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Autore |
Bloomfield Hanna E. |
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Titolo |
Predictors and consequences of severe hypoglycemia in adults with diabetes : a systematic review of the evidence / / Hanna E. Bloomfield [and seven others] |
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Pubbl/distr/stampa |
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Washington, District of Columbia : , : Department of Veterans Affairs (US), , [2012] |
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©2012 |
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Descrizione fisica |
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1 online resource (iii, 163 pages) : illustrations |
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Disciplina |
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Soggetti |
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Diabetics |
Diabetics - Diet therapy |
United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Evidence-based synthesis program." |
"April 2012." |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Prevalence of type 2 diabetes is increasing at an alarming pace, fueled by the rising rates of overweight and obesity in many populations. In the VA healthcare system, the prevalence of diabetes was 20% in fiscal year 2000 and is now estimated at nearly 25%. Although people with diabetes have a substantially increased risk of cardiovascular disease (CVD), recent trials show that intensive glucose lowering does not reduce the risk of CVD death or all-cause mortality although it reduces the risk of microvascular complications (nephropathy, retinopathy and neuropathy) and possibly non-fatal myocardial infarction. Intensive glucose control also increases the risk of hypoglycemic episodes. Several recent meta-analyses of the trials comparing intensive to conventional glucose control concluded that intensive control is associated with a 2-2.5 fold increased risk of severe hypoglycemia. The reviews however have not included smaller randomized trials, trials focused on the comparison of specific drug regimens, and non-randomized trials. We conducted the current review to provide broader |
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insight into the incidence of, the risk factors for, and the clinical and social impact of severe hypoglycemia in adults with type 2 diabetes treated with glucose lowering medications. |
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