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1. |
Record Nr. |
UNINA9910709789003321 |
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Autore |
Mead Jaylee M. |
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Titolo |
Future of ultraviolet astronomy based on six years of IUE research : proceedings of a symposium held at NASA Goddard Space Flight Center, Greenbelt, Maryland, April 3-5, 1984 / / edited by Jaylee M. Mead, Robert D. Chapman, and Yoji Kondo |
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Pubbl/distr/stampa |
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Washington, D.C. : , : National Aeronautics and Space Administration, Scientific and Technical Information Branch, , 1984 |
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Descrizione fisica |
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1 online resource (xiv, 544 pages) : illustrations |
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Collana |
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NASA conference publication ; ; 2349 |
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Classificazione |
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Soggetti |
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Astronomy |
Ultraviolet astronomy |
Galaxies |
Nebulae |
Hot stars |
Solar system |
Astronomy - Observations |
Conference papers and proceedings. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references. |
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2. |
Record Nr. |
UNINA9910576878903321 |
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Autore |
Handgretinger Rupert |
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Titolo |
Advance in the Treatment of Pediatric Leukemia |
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Pubbl/distr/stampa |
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Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
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Descrizione fisica |
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1 online resource (300 p.) |
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Soggetti |
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Chemistry |
Research & information: general |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The book gives an overview on the progress that has been made in the treatment of acute lymphoblastic leukemia (ALL), of acute and chronic myeloid leukemia (AML, CML) and of juvenile myelomonocytic leukemia (JMML). Leukemia is the most common malignant disease in children, and 80% of patients are diagnosed with ALL and 15-20% with AML, whereas CML and JMML are rather rare. Although ALL was considered an incurable disease until the early 1960s, with the availability of cytotoxic drugs and the start of clinical multicenter studies, ALL has become an almost curable disease with a survival rate exceeding 90 % in high-income countries. These impressive results have mainly been achieved by a deeper understanding of the genomic landscape of the disease and the introduction of risk stratifications based on genetic features and response to chemotherapy as determined by the presence or absence of minimal residual disease (MRD). Immunotherapies including bispecific T-cell Engagers (BiTEs), Chimeric Antigen Receptor (CAR) T cells, monoclonal antibodies and improvements in the outcome of allogeneic stem cell transplantation (HSCT) have shown impressive results in chemorefractory or relapsed patients, and it is anticipated that the cure rate can be further increased. For countries with less resources, therapies have to be adapted to increase survival as well. This book also updates on the progress made in the treatment of AML. As in ALL, risk classification based on genetic factors and response to |
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chemotherapy is most important for therapy guidance. The book also provides updates and guidance for the treatment of CML and JMML. |
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