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1. |
Record Nr. |
UNICASTSA0770620 |
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Autore |
Mann, Thomas <1875-1955> |
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Titolo |
Tristan : novelle / Thomas Mann ; Nachwort von Hermann Kurzke |
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Pubbl/distr/stampa |
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Stuttgart, : Reclam, ©1988 |
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ISBN |
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Descrizione fisica |
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Collana |
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Universal Bibliothek ; 6431 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910786862603321 |
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Titolo |
China's cyberwarfare capability / / Elisabette M. Marvel |
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Pubbl/distr/stampa |
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New York, : Nova Science Publishers, c2010 |
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ISBN |
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Descrizione fisica |
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1 online resource (viii, 105 pages) : illustrations |
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Collana |
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China in the 21st century |
Computer science, technology and applications |
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Classificazione |
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Altri autori (Persone) |
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Soggetti |
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Information warfare - China |
Cyberspace - Security measures |
Information warfare - United States - Prevention |
Computer networks - Security measures - United States |
China Military policy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Capability of the people's republic of China to conduct cyber warfare and computer network exploitation / Bryan Krekel ... [et al.] before the |
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U.S.-China Economic and Security Review Commission -- China's approach to cyber operations : implications for the United States / Larry M. Wortzel Commissioner, U.S.-China Economic and Security Review Commission, Hearing on "The Google predicament : transforming U.S. cyberspace policy to advance democracy, Security and Trade". |
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Sommario/riassunto |
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The government of the People's Republic of China (PRC) is a decade into a sweeping military modernisation program that has fundamentally transformed its ability to fight high tech wars. The Chinese military, using increasingly networked forces capable of communicating across service arms and among all echelons of command, is pushing beyond its traditional missions focused on Taiwan and toward a more regional defence posture. This book presents a comprehensive open source assessment of China's capability to conduct computer network operations (CNO) both during peacetime and periods of conflict, and will hopefully serve as a useful reference to policymakers, China specialists, and information operations professionals. |
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3. |
Record Nr. |
UNINA9910688321803321 |
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Autore |
Almeida Catarina R |
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Titolo |
Immunomodulation of Innate Immune Cells |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (204 p.) |
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Soggetti |
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Immunology |
Medicine and Nursing |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Activation of innate immune system underlies both pathological and physiological inflammatory responses and is critical for the host. Regulated innate immune response is thus essential not only for the elimination of invading pathogens but also for the restoration of tissue |
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homeostasis. The innate immune system relies on the expression of families of highly conserved Pattern Recognition Receptors (PRRs) by specialised immune cells such as macrophages or dendritic cells. Engagement of PRRs by microbial or host-derived danger signals coordinates the cellular innate immune response. While some receptors such as Toll-like Receptors (TLRs) and C-type Lectin Receptors (CLRs) are membrane bound, others like the Retinoic-acid-Inducible Gene I (RIG-I)-Like Receptors (RLRs), Nucleotide-binding Oligomerization Domain (NOD)-Like Receptors (NLRs) and several DNA receptors (e.g. AIM2, cGAS) are expressed in the cytosol. Moreover, several molecules released by innate immune cells including complement proteins and members of the pentraxin family act as soluble PRRs. Activation of PRRs initiate specific signal transduction cascades, which lead to transcription and secretion of inflammatory mediators, thereby facilitating inflammation. Furthermore, some PRRs can form large oligomeric protein complexes called inflammasomes that instigate proteolytic maturation of members of the IL-1 family of cytokines, thereby driving inflammatory programmed cell death. Current research on immunomodulation is focused on understanding the fundamental mechanisms that control the activation and regulation of innate immune cell function. This includes exciting advances in understanding signals that can polarize innate immune cells into different functional states, for instance from a more inflammatory to a more tolerogenic profile. However, this response of innate immune cells critically depends on several intrinsic and extrinsic factors such as their own biological status and their microenvironmental context, respectively. For instance, it is known that the extracellular matrix or biomaterials can modulate macrophage behavior and that autophagy flux is a critical regulator of inflammation. Consistent with this, there has been an increase in the development of novel drugs and biomaterials aimed at inducing immunomodulatory responses in targeted innate immune cell populations to be used in the context of tissue regeneration, cancer, autoimmune disease etc. Thus, a thorough understanding of immunomodulatory mechanisms of innate immune cells will guide the development of novel therapeutic strategies aimed to control inflammation-mediated pathologies. In this Research Topic, we aim to highlight recent advances in our understanding of the fundamental mechanisms controlling activation of innate immune cells and document new strategies to study and manipulate their immunomodulation. |
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