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Record Nr. |
UNINA9910683396103321 |
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Autore |
Gozlinski Thomas |
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Titolo |
Local Probing of a Superconductor's Quasiparticles and Bosonic Excitations with a Scanning Tunnelling Microscope / / Thomas Gozlinski, Wulf Wulfhekel, Jörg Schmalian |
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Pubbl/distr/stampa |
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Karlsruhe : , : KIT Scientific Publishing, , 2023 |
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Descrizione fisica |
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1 online resource (iii, 190 pages) : illustrations |
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Collana |
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Experimental condensed matter physics |
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Disciplina |
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Soggetti |
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Microscopes |
Superconductivity |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Complementary to scattering techniques, scanning tunnelling microscopy provides atomic-scale real space information about a material's electronic state of matter. State-of-the-art designs of a scanning tunnelling microscope (STM) allow measurements at millikelvin temperatures with unprecedented energy resolution. Therefore, this instrument excels in probing the superconducting state at low temperatures and especially its local quasiparticle excitations as well as bosonic degrees of freedom. |
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2. |
Record Nr. |
UNINA9910961776903321 |
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Titolo |
Animal models for assessing countermeasures to bioterrorism agents / / Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents |
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Pubbl/distr/stampa |
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Washington, D.C., : National Academies Press, 2011 |
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ISBN |
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9786613527127 |
9780309219129 |
0309219124 |
9781280123269 |
1280123265 |
9780309219105 |
0309219108 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (151 p.) |
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Disciplina |
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Soggetti |
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Bioterrorism |
Biology, Experimental |
Animal models in research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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""Front matter""; ""Acknowledgments""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Evaluation of Current and Future TMT-Used Animal Models""; ""3 Ethical and Regulatory Challenges in the Development of Countermeasures""; ""4 Developing New Animal Models for Biodefense Research""; ""5 Alternative Approaches to Animal Testing for Biodefense Countermeasures""; ""Appendix A: The Animal Rule""; ""Appendix B: Draft Guidance for Industry""; ""Appendix C: Developing Animal Models for Use in Animal Rule Licensure: The NIAID Approach""; ""Appendix D: Presentations to the Committee"" |
""Appendix E: Statement of Task""""Appendix F: About the Authors"" |
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Sommario/riassunto |
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"The Transformational Medical Technologies (TMT) has been a unique component of the U.S. Department of Defense (DoD) medical biodefense efforts since 2006. Its mission is to advance |
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countermeasure research and development in support of the broader goal of the DoD to protect warfighters from emerging infectious diseases and future genetically engineered biological weapons. The TMT, using advanced science and technology approaches, focused on the development of roadspectrum countermeasures that target common host and pathogen pathways or enhance the host's immune response. Many of these pathogens are lethal or cause such debilitating diseases in humans that it is ethically inappropriate to test the efficacy of these countermeasures in human volunteers. In lieu of human participants, these products may be tested in animals and approved for human use under the provisions of the Food and Drug Administration (FDA)'s 2002 Animal Rule. The reliance on animal models for the development and licensure of medical countermeasures against biothreats is challenging for a number of reasons. The ad hoc Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents prepared a consensus report that would address the challenges stemming from developing and testing medical countermeasures against biothreat agents in animal models. Animal Models for Assessing Countermeasures to Bioterrorism Agents evaluates how well the existing TMT-employed or candidate animal models reflect the pathophysiology, clinical picture, and treatment of human disease as related to the agents of interest. The report addresses the process and/or feasibility of developing new animal models for critical biodefense research, placing emphasis on the need for a robust and expeditious validation process in terms of the FDA's Animal Rule. The report also evaluates alternatives to the use of animal models based on the premise of the Three Rs"--Publisher's description. |
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