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1. |
Record Nr. |
UNINA9910145765203321 |
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Autore |
Lyshevski Sergey Edward |
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Titolo |
Engineering and scientific computations using MATLAB [[electronic resource] /] / Sergey E. Lyshevski |
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Pubbl/distr/stampa |
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Hoboken, : Wiley-Interscience, c2003 |
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ISBN |
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1-280-27333-X |
9786610273331 |
0-470-35753-3 |
0-471-72385-1 |
0-471-72386-X |
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Descrizione fisica |
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1 online resource (239 p.) |
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Disciplina |
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Soggetti |
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Engineering mathematics - Data processing |
Science - Data processing |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Engineering and Scientific Computations Using MATLAB®; CONTENTS; Preface; About the Author; 1. MATLAB Basics; 1.1. Introduction; 1.2. MATLAB Start; 1.3. MATLAB Help and Demo; References; 2. MATLAB Functions, Operators, and Commands; 2.1. Mathematical Functions; 2.2. MATLAB Characters and Operators; 2.3. MATLAB Commands; References; 3. MATLAB and Problem Solving; 3.1. Starting MATLAB; 3.2. Basic Arithmetic; 3.3. How to Use Some Basic MATLAB Features; 3.3.1. Scalars and Basic Operations with Scalars; 3.3.2. Arrays, Vectors, and Basic Operations; 3.4. Matrices and Basic Operations with Matrices |
3.5. Conditions and Loops3.6. Illustrative Examples; References; 4. MATLAB Graphics; 4.1. Plotting; 4.2. Two- and Three-Dimensions Graphics; 4.3. Illustrative Examples; References; 5. MATLAB Applications: Numerical Simulations of Differential Equations and Introduction to Dynamic Systems; 5.1. Solution of Differential Equations and Dynamic Systems Fundamentals; 5.2. Mathematical Model Developments and MATLAB Applications; 5.3. Modeling and Computing |
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Using MATLAB; References; 6. SIMULINK; 6.1. Introduction to SIMULINK; 6.2. Engineering and Scientific Computations Using SIMULINK with Examples |
ReferencesAPPENDIX: MATLAB Functions, Operators, Characters, Commands, and Solvers; References; Index |
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Sommario/riassunto |
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Master MATLAB(r) step-by-stepThe MATLAB-- ""MATrix LABoratory""--computational environment offers a rich set of capabilities to efficiently solve a variety of complex analysis, simulation, and optimization problems. Flexible, powerful, and relatively easy to use, the MATLAB environment has become a standard cost-effective tool within the engineering, science, and technology communities. Excellent as a self-teaching guide for professionals as well as a textbook for students, Engineering and Scientific Computations Using MATLAB helps you fully understand the MATLAB environment, build your sk |
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2. |
Record Nr. |
UNINA9910694501203321 |
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Titolo |
Enlisting foreign cooperation in U.S. efforts to prevent nuclear smuggling : hearing before the Subcommittee on [the] Prevention of Nuclear and Biological Attack of the Committee on Homeland Security, House of Representatives, One Hundred Ninth Congress, second session, May 25, 2006 |
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Descrizione fisica |
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1 online resource (iii, 47 p.) |
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Soggetti |
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Nuclear terrorism - United States - Prevention - International cooperation |
Smuggling - United States - Prevention - International cooperation |
Radioactive substances - Detection - International cooperation |
Ports of entry - Security measures - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910676563703321 |
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Titolo |
Drug discovery and development . Volume 1 Drug discovery / / edited by Mukund S. Chorghade |
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Pubbl/distr/stampa |
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Hoboken, NJ, : Wiley-Interscience, c2006 |
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ISBN |
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9786610468430 |
9781280468438 |
1280468432 |
9780470320778 |
047032077X |
9780471780106 |
0471780103 |
9780471780090 |
047178009X |
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Descrizione fisica |
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1 online resource (478 p.) |
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Altri autori (Persone) |
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ChorghadeMukund S (Mukund Shankar) |
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Disciplina |
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Soggetti |
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Drug development |
Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Contributors; Preface; 1 From Patent to Prescription: Paving the Perilous Path to Profit; 1.1 Introduction; 1.2 A Simple Solution to a Complex Problem; 1.3 An Intriguing Patent Problem; 1.4 Another Structural Insight; References; 2 Medicinal Chemistry in the New Millennium: A Glance into the Future; 2.1 Introduction; 2.2 Practice of Medicinal Chemistry; 2.2.1 Emergence as a Formalized Discipline; 2.2.2 Early Developments; 2.2.3 Present Status; 2.2.4 Examples Involving Site-Directed Mutagenesis; 2.2.5 Latest Trends |
2.3 Evolving Drug Discovery and Development Process2.3.1 Working Definition for Medicinal Chemistry; 2.3.2 Immediate- and Long-Term Roles for Medicinal Chemistry; 2.4 Pursuing Efficacy; 2.4.1 Gathering |
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Positive, Neutral, and Negative SARs During HTS; 2.4.2 Example Involving Multidrug Resistance of Anticancer Agents; 2.4.3 Compound Libraries: Example of Working with Nature to Enhance Molecular Diversity; 2.5 Assessing and Handling Molecular Conformation; 2.5.1 Chemoinformatics; 2.5.2 Obtaining Chemically Correct 3D Structures |
2.5.3 Influence of Biological Environments: Example Involving Drug Metabolism2.5.4 Dynamic Energy Relationships: Example Involving a Small Ring System; 2.5.5 Druglike Properties and Privileged Structures; 2.5.6 Tiered Structural Information and Searching Paradigms; 2.6 ADMET Considerations; 2.6.1 Assuring Absorption; 2.6.2 Directing Distribution; 2.6.3 Herbal Remedies: Example of Working with Nature to Discover ADMET-Related Synergies; 2.6.4 Brute Force HTS to Uncover Multicomponent Synergies; 2.6.5 Controlling Metabolism: Example Involving a Soft Drug Strategy; 2.6.6 Optimizing Excretion |
2.6.7 Avoiding Toxicity2.6.8 Weighting Decision Criteria from Efficacy and ADMET SAR; 2.7 Process Chemistry Considerations; 2.7.1 Cost and Green Chemistry; 2.7.2 Defining Stereochemistry: Example Involving Benzylamine Chiral Auxiliary Synthetic Reagents; 2.8 Analytical Chemistry/X-ray Diffraction; 2.8.1 Latest Trends; 2.8.2 Examples Involving Dopamine Receptors, c-AMP Phosphodiesterase Enzymes, and the Dynamics of Protein Folding; 2.9 Summary; 2.9.1 General Points; 2.9.2 Attributes of Drug Discovery Libraries, Compound Hits, and Lead Compounds |
2.9.3 Formalized Instruction of Medicinal Chemistry2.9.4 Intellectual Property Considerations; 2.9.5 Knowledge Versus Diversity Paradox; Acknowledgments; References and Notes; 3 Contemporary Drug Discovery; 3.1 Introduction; 3.1.1 Getting Started; 3.2 Characteristics of a Suitable Lead Substance; 3.2.1 Potency and Selectivity; 3.2.2 Structure-Activity Relationships; 3.2.3 Toxicity; 3.2.4 Changing Appellation of the Best in Series: Analog Attrition; 3.3 Some Criteria That a Hit Must Satisfy to Become a Drug; 3.3.1 Level of Potency; 3.3.2 Comparison of Potency and Efficacy |
3.3.3 Druglike Character |
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Sommario/riassunto |
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This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil)Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancerContains chapters on combinatorial chemistry, molecular biology-based drug discovery |
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