ABC Transporters in Human Diseases

• Record Nr.: UNINA9910674029103321
• Autore: Falguières Thomas
• Pubbl/distr/stampa: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 electronic resource (494 p.)
• Soggetti: Research & information: general; Biology, life sciences
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.

Peter the Venerable and Islam / / James Kritzeck

• Record Nr.: UNINA9910823717003321
• Autore: Kritzeck James
• Pubbl/distr/stampa: Princeton, New Jersey : , : Princeton University Press, , 1964; ©1964
• ISBN: 0-691-65142-6; 1-4008-7577-3
• Descrizione fisica: 1 online resource (316 pages)
• Collana: Princeton Legacy Library; Princeton Oriental Studies ; ; Number 23
• Disciplina: 297
• Soggetti: Christianity and other religions - Islam; Islam - Relations - Christianity
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: An analysis and new annotated edition of the following texts: Summa totius haeresis Saracenorum. Epistola Petri Cluniacensis ad Bernardum Claraevallis. Epistola Petri Pictavensis. Capitula Petri Pictavensis. Liber contra sectam sive haeresim Saracenorum.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Front matter -- Preface -- Contents -- I. Peter The Venerable -- 1. The Journey To Spain -- 2. The Crusade: A Missing Goal -- 3. The Project To Study Islam -- 4. The Appeal To Patristic Authority -- 5. The Double Purpose -- II. The Translators -- 1. The School of Toledo -- 2. Peter of Toledo -- 3. Peter of Poi tiers -- 4. Robert of Ketton -- 5. Herman of Dalmatia -- 6. Mohammed -- III. The Translations -- 1. MS 1162 of the Bibliothèque de l'Arsenal -- 2. The Fabulae Saracenorum -- 3. The Liber generationis Mahumet -- 4. The Doctrina Mahumet -- 5. The Koran -- 6. The Epistola Saraceni and Rescriptum Christiani -- 7. The Choice and Accuracy of the Translations -- IV. The Summary -- 1. The Summa totius haeresis Saracenorum -- 2. God, Christ, and the Last Judgment -- 3. Mohammed the Prophet -- 4. The Koran and Its Sources -- 5. Heaven, Hell, and Moral Precepts -- 6. The Spread of Islam -- 7. Islam as a Christian Heresy -- 8. The Value of the Summary -- V. The Refutation -- 1. MS 381 of the Bibliotheque municipale de Douai and the Capitula of Peter of Poitiers -- 2. The Prologue -- 3. Book One: I -- 4. Book One: II -- 5. Book Two: I -- 6. Book Two: II -- 7. ; The Stature of the Refutation -- VI. Texts -- 1. A Note on the Texts -- 2. Summa totius haeresis Saracenorum -- 3. Epistola Petri Cluniacensis ad Bernardum Claraevallis -- 4. Epistola Petri Pictavensis -- 5. Capitula Petri Pictavensis -- 6. Liber contra sectam sive haeresim Saracenorum -- Index
• Sommario/riassunto: For over four centuries the principal source of Christian European knowledge of Islam stemmed from a project sponsored by Peter the Venerable, ninth abbot of Cluny, in 1142. This consisted of Latin translations of five Arabic works, including the first translation of the Koran in a western language. Known as the Toledan Collection, it was eventually printed in 1543 with an introduction by Martin Luther. The abbot also completed a handbook of Islam beliefs and a major analytical and polemical work, Liber contra sectam Saracenorum; annotated editions of these texts are included in this book. Originally published in 1964.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.