| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910674023003321 |
|
|
Titolo |
Chemical and Molecular Approach to Tumor Metastases / / edited by Gianni Sava and Alberta Bergamo |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 |
|
©2018 |
|
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (vii, 264 pages) : illustrations |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references. |
|
|
|
|
|
|
Sommario/riassunto |
|
Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin. The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on "Chemical and Molecular Approach to |
|
|
|
|
|
|
|
|
|
|
|
|
|
Tumor Metastases" will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases. With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome. |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910774758203321 |
|
|
Titolo |
The afterlife of the Shoah in Central and Eastern European cultures : concepts, problems, and the aesthetics of postcatastrophic narration / / edited by Anna Artwińska, Anja Tippner |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Abingdon, Oxon : , : Routledge, an imprint of the Taylor & Francis Group, an informa business, , 2021 |
|
©2021 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-00-305054-9 |
1-000-46388-5 |
1-003-05054-9 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (384 pages) |
|
|
|
|
|
|
Collana |
|
Routledge studies in cultural history |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Catastrophical, The, in literature |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Sommario/riassunto |
|
"The Afterlife of the Shoah in Central and Eastern European Cultures is a collection of essays by literary scholars from Germany and Central |
|
|
|
|
|
|
|
|
|
|
Eastern Europe offering insight into the specific ways of representing the Shoah and its aftereffects as well as its entanglement with other catastrophic events in the region. Introducing the conceptual frame of postcatastrophe, the collected essays explore the discursive and artistic space the Shoah occupies in the countries between Moscow and Berlin. Postcatastrophe is informed by the knowledge of other concepts of "post" and shares their insight into forms of transmission and latency; in contrast to them, explores the after-effects of extreme events on a collective, aesthetic, and political rather than a personal level. The articles use the concept of postcatastrophe as a key to understanding the entangled and conflicted cultures of remembrance in postsocialist literatures and the arts dealing with events, phenomena and developments that refuse to remain in the past and still continue to shape perceptions of today's societies in Eastern Europe. As a contribution to memory studies as well as to literary criticism with a special focus on Shoah remembrance after socialism, this book is of great interest to students and scholars of European history, and those interested in historical memory more broadly". |
|
|
|
|
|
| |