| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910648000003321 |
|
|
Autore |
Giovagnoli, Roberto |
|
|
Titolo |
Il contratto / Roberto Giovagnoli |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Torino, : Itaedizioni, 2020 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[2. ed.] |
|
|
|
|
|
Descrizione fisica |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Locazione |
|
|
|
|
|
|
Collocazione |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
2. |
Record Nr. |
UNINA9910508459303321 |
|
|
Autore |
Mizusawa Hidehiro |
|
|
Titolo |
Cerebellum as a CNS Hub / / edited by Hidehiro Mizusawa, Shinji Kakei |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2021.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (543 pages) |
|
|
|
|
|
|
Collana |
|
Contemporary Clinical Neuroscience, , 2627-5341 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Neurosciences |
Neuroscience |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di contenuto |
|
Intro -- Preface -- Contents -- Part I: Evolution and Development of the Cerebellum -- Chapter 1: Evolutionary and Developmental |
|
|
|
|
|
|
|
|
|
Perspectives on the Origin and Diversification of the Vertebrate Cerebellum -- 1.1 The Origin of Vertebrates -- 1.2 Cyclostomes -- 1.3 Gnathostomes -- 1.4 The Vertebrate Brain -- 1.5 Diversity of the Vertebrate Cerebellum -- 1.6 The Cerebellum in Mammals -- 1.7 The Cerebellum in Flying Vertebrates -- 1.8 The Origin of the Cerebellum: A Paleontological Study -- 1.9 The Origin of the Cerebellum: A Comparative Study -- 1.10 Cerebellar Cytoarchitecture -- 1.11 The Origin of Cerebellar Neurons -- 1.12 Combinatory Expression of Regulatory Genes in the Anterior Rhombencephalon -- 1.13 Organizing Centers -- 1.14 IsO in Cyclostomes -- 1.15 The Origin of the Cerebellar Cytoarchitecture -- 1.16 The Origin and Diversification of the Cerebellum -- References -- Chapter 2: Cerebellum-Like Systems in Actinopterygian Fishes with a Special Focus on the Diversity of Cerebellum-Like System in the Mesencephalon -- 2.1 Introduction -- 2.2 Widespread Distribution of CLSs in Vertebrates (Figs. 2.1 and 2.2) -- 2.3 Multitude of Cerebellum-Like Systems in Actinopterygians -- 2.4 Rhombencephalic CLSs (RCLSs) in Actinopterygians -- 2.4.1 Structural Organization and Neural Circuitry -- Medial Octavolateral Nucleus (NM) -- Dorsomedial Zone of Descending Octaval Nucleus (DOdm) -- Secondary Octaval Population (SOP) -- Dorsal Octavolateral Nucleus (DON) -- Electrosensory Lateral Line Lobe (ELL) -- 2.4.2 Functional Significances of RCLSs -- 2.5 Mesencephalic Cerebellum-Like System in Acanthopterygians: TL-TO System -- 2.5.1 Structural Organization and Neural Circuitry -- 2.5.2 Functional Significances of TL-TO System -- 2.5.3 Diversity of Torus TL-TO System in Actinopterygians. -- References. |
Chapter 3: Modeling of Human Cerebellar Development and Diseases with Pluripotent Stem Cell-Derived Brain Organoids -- 3.1 Introduction -- 3.2 Cerebellar Development -- 3.3 Recapitulation of Cerebellar Development with PSCs -- 3.4 Investigation of Cerebellar Diseases with PSCs -- 3.5 Spinocerebellar Ataxias -- 3.6 Cerebellar Malformations -- 3.7 Future Perspective -- References -- Chapter 4: mGluR1 Is a Molecular "Hub" for Synapse Elimination in the Developing Cerebellum -- 4.1 Prologue -- 4.2 mGluR1 Is Essential for LTD at Parallel Fiber to Purkinje Cell Synapse -- 4.3 mGluR1 Is Essential for Climbing Fiber Synapse Elimination in the Developing Cerebellum -- 4.4 Downstream Molecules of mGluR1 Involved in Climbing Fiber Synapse Elimination -- 4.5 mGluR1 Mediates Parallel Fiber Synapse Elimination Following the Late Phase of Climbing Fiber Elimination -- 4.6 Conclusion: mGluR1 Is a Molecular "Hub" for Purkinje Cell Synaptic Development and Function -- References -- Part II: Neurocircuitry of the Cerebellum -- Chapter 5: Cerebellar Lobules and Stripes, Viewed from Development, Topographic Axonal Projections, Functional Localization, and Interspecies Homology -- 5.1 Introduction -- 5.2 Cerebellar Lobules -- 5.2.1 Lobules in the Vermis -- 5.2.2 Lobules in the Hemisphere -- 5.3 Longitudinal Stripes and the Relationship between Lobules and Stripes -- 5.4 Development of Cerebellar Lobules and Stripes -- 5.5 The Relationship to Axonal Projections of Lobules and Stripes -- 5.5.1 Climbing Fiber and Purkinje Cell Projections -- 5.5.2 Mossy Fiber Axons -- 5.5.3 Cerebellar Nucleus Projections -- 5.6 Functional Localization in Lobules and Stripes -- 5.7 Concluding Remarks -- References -- Chapter 6: Olivocerebellar Somatotopy Revisited -- 6.1 Introduction -- 6.2 Penfield's Homunculus and Woolsey's Simiusculus in the Cerebral Cortex. |
6.3 The Somatotopy in the Cerebellum -- 6.3.1 Snider's Cerebellar Homunculi -- 6.3.2 Oscarsson's Longitudinal Somatotopy -- 6.3.3 Eccles's Patchy Distribution of Climbing Fiber Projections -- 6.4 Large- |
|
|
|
|
|
|
|
Scale Optical Measurements of Cerebellar Complex Spikes -- 6.5 Distributed Sensory Representation in Unit of Olivocerebellar Segments -- References -- Chapter 7: Purkinje Cell Dendrites: The Time-Tested Icon in Histology -- 7.1 Anatomical and Geometrical Features of Developing and Mature PC Dendrites -- 7.1.1 Unique Morphology of PC Dendrites and their Synaptic Inputs -- 7.1.2 Multistep Morphological Development of Dendrites -- 7.1.3 PCs as a Model System for the Study of Dendritic Morphogenesis -- 7.2 Strategies for a Mechanistic Understanding of PC Dendritic Morphogenesis -- 7.2.1 In Vitro Culture Systems -- 7.2.2 Genetic Strategies to Label and Manipulate PCs in Vivo -- 7.3 Molecular Mechanisms Underlying Stepwise Dendritogenesis -- 7.3.1 The Transition from the Fusiform to Stellate-Cell Stages: Roles of RORα -- 7.3.2 The Transition from Stellate-Cell to Young PC Stage: Selective Growth of Single Primary Dendrites -- RORα, Thyroid Hormones, and aPKC -- Extracellular Matrix (ECM) and Granule Cells -- 7.3.3 From Young to Mature PC Stages: Branch Formation and Growth of the Dendritic Tree -- RORα and Thyroid Hormones -- Synapse Formation-Independent and Synapse Formation-Dependent Roles of Granule Cells -- 7.3.4 From Young to Mature PC Stage: Formation of the Planar Dendritic Arbor -- ECM, Bergman Glia, PFs, and CFs -- 7.3.5 From Young to Mature PC Stage: Dendritic Self-Avoidance -- 7.3.6 Mature PCs: Maintenance of Mature Dendrites -- 7.4 Conclusions and Future Perspectives -- References -- Chapter 8: Physiological Roles of Perineuronal Nets in Cerebellar Functions -- 8.1 Introduction -- 8.2 Expression of PNNs in the Cerebellum. |
8.3 Functional Roles of PNNs in GABAergic Transmission in the DCN -- 8.4 Possible Mechanisms Underlying PNN Regulation of Presynaptic GABA Release -- 8.5 PNN Depletion Facilitates Rebound Firing in Large DCN Neurons -- 8.6 PNNs in the Interpositus Nuclei Regulate Delay Eyeblink Conditioning -- 8.7 Conclusion -- References -- Part III: Information Processing in the Cerebellar Neurocircuitry and Its Model -- Chapter 9: Roles of Cerebellum-Brainstem Loops in Predictive Optokinetic Eye Velocity Control in Fish, Mice, and Humans -- 9.1 Predictive Optokinetic Response (pOKR) in Goldfish -- 9.1.1 General Characteristics -- 9.1.2 Prediction of Stimulus Initiation and Termination -- 9.2 Neuronal Network Subserving OKR -- 9.3 Roles of the Cerebellum in pOKR -- 9.3.1 Purkinje Cell Activity during pOKR -- 9.3.2 Effects of Cerebellectomy before and after Acquisition of pOKR -- 9.4 pOKR in Other Animal Species -- 9.4.1 pOKR in Different Fish Species -- 9.4.2 pOKR in Mice and Humans -- 9.5 The Velocity Storage Mechanism as a Possible Determinant of pOKR -- 9.5.1 The Velocity Storage Mechanism (VSM) -- 9.5.2 OKAN and the VSM -- 9.5.3 OKAN in Animals Capable and Incapable of Acquiring pOKR -- 9.5.4 Effects of VIIIth Nerve Neurectomy on OKAN and pOKR -- 9.5.5 OKAN Habituation after the Acquisition of pOKR -- 9.6 Summary and Conclusion -- References -- Chapter 10: Fastigial Nucleus Input/Output Related to Motor Control -- 10.1 Introduction -- 10.2 General Structure of the Cerebellar Cortex and the Cerebellar and Vestibular Nuclei -- 10.2.1 Axonal Trajectories of Single Olivocerebellar Neurons -- 10.2.2 Longitudinal Zones A-D and their Relationship with Aldolase C Bands -- 10.2.3 Aldolase C Compartments in the Cerebellar Nucleus -- 10.2.4 General Structure of the "Microcomplex" of Cerebellar Input-Output Organization. |
10.2.5 Compartmentalization of the Entire CN and its Correspondence to the Aldolase C Expression Pattern in the CN -- 10.3 Input-Output Organization of the Fastigial Nucleus -- 10.3.1 Efferent System of the Fastigial Nucleus -- Fastigiovestibular Projection -- Projection |
|
|
|
|
|
|
|
|
|
of the Contralateral FN to the Vestibular Nuclei -- Projection of the Ipsilateral FN to the Vestibular Nuclei -- Fastigioreticular Projections -- Fastigiospinal Projections -- Fastigial Projection to the Superior Colliculus -- Fastigio-Thalamo-Cerebral Projection -- 10.3.2 Afferents to the Fastigial Nucleus -- Vestibular Projection to the Fastigial Nucleus -- Spinal Projection to the Fastigial Nucleus -- 10.4 Conclusion -- References -- Chapter 11: Evolution of the Marr-Albus-Ito Model -- 11.1 Introduction -- 11.2 Evolutionary Tree of the Marr-Albus-Ito Model -- 11.2.1 The Marr-Albus-Ito Model -- 11.2.2 Applications to Behavioral Studies -- Eye Movement Control -- Eyeblink Conditioning -- 11.2.3 Granular Layer Encoding -- 11.2.4 Information Capacity of Purkinje Cells -- 11.2.5 Distributed Synaptic Plasticity -- 11.2.6 Internal Models -- 11.2.7 General Computational Principles -- 11.2.8 Olivocerebellar System -- 11.3 Perspectives -- 11.3.1 Summary of the Evolutionary Tree -- 11.3.2 Unresolved Issues -- Distributed Versus Similar Coding in the Granular Layer -- Information Representation by Mossy Fiber and Climbing Fiber Signals -- Localized Versus Distributed Computation Revealed by Distributed Climbing Fiber Activity -- 11.3.3 Future Directions -- 11.4 Conclusion -- References -- Part IV: Complex Spikes and Plasticity of the Cerebellar Neurocircuitry -- Chapter 12: States Are A-Changing, Complex Spikes Proclaim -- 12.1 Internal Models and the Cerebellum -- 12.2 Cerebellum as a Forward Internal Model. |
12.2.1 Patient and Functional Imaging Evidence for the Hypothesis in the Motor Domain. |
|
|
|
|
|
|
Sommario/riassunto |
|
Based on the 75th Fujihara Seminar held in December 2018 in Tokyo, Japan, this volume explores the latest research on the cerebellum. Contributors seek to examine the cerebellum's role as a unique hub for brain activity and discover new information about its purpose. The discussion is broad, ranging from evolutionary topics to therapeutic strategy and addresses both physiology and pathology. Subjects covered include anatomy, information processing, complex spikes, plasticity, modeling, and spinocerebellar ataxias. The volume is intended to set the stage for the future of cerebellar research and guide both basic and clinical researchers. |
|
|
|
|
|
|
|
| |