1.

Record Nr.

UNINA9910643200403321

Titolo

Ciba Foundation Symposium on the Chemistry and Biology of Purines [[electronic resource] /] / editors for the Ciba Foundation, G.E.W. Wolstenholme and Cecilia M. O'Connor

Pubbl/distr/stampa

Boston, : Little, Brown and Co., [1957]

ISBN

1-280-76855-X

9786613679321

0-470-71901-X

0-470-71648-7

Descrizione fisica

1 online resource (350 p.)

Collana

Ciba Foundation symposia

Altri autori (Persone)

WolstenholmeG. E. W (Gordon Ethelbert Ward)

O'ConnorCecilia M <1927-> (Cecilia Mary)

Disciplina

612.015

Soggetti

Purines

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

CHEMISTRY AND BIOLOGY OF PURINES; CONTENTS; Opening remarks; Synthesis and properties of purines of potential biological interest; Discussion; Some synthetic studies on purines and related heterocycles; Discussion; Some new -N-methylpurines; The structure of the hydroxypurines investigated by O-and N-methylation; Discussion; The spectra and structure of the monohydroxypurines and other potentially tautomeric purines; Short Communication; The p-electron properties of purine calculated by the L.C.A.O. method; Discussion; The degradation of uric acid by water under pressure

The 8-position in purines. The chemical and biological transformation of purines into pteridines Discussion; Cvclonucleosides; Discussion; Stereochemistry of nucleoside synthesis; Discussion; Synthetic chemical investigations related to the metabolism of purines; Discussion; The effects of potential antipurines on a purine-requiring strain of Escherichla coli; Discussion; The chemistry of new purines in the B12 series of vitamins; Biological and microbiological activity of purine analogues of vitamin B12; Discussion; Puromycin; Discussion

Chemical and biological behaviours of 9-b-D-ribofuranosylpurine



Discussion; On the activation of the one-carbon unit for the biosynthesis of purine nucleotides; The enzymatic synthesis of inosinic acid de novo; Discussion; Enzymic control of purines by xanthine oxidase; Discussion; The biological effects of 8-azapurines; Discussion; Biochemical effects of 6-mercaptopurine; Discussion; The use of 6-mercaptopurine in the treatment of leukemia; Discussion; General Discussion; Chairman's closing remarks