Oxygen free radicals and tissue damage [[electronic resource]]

• Record Nr.: UNINA9910642833003321
• Pubbl/distr/stampa: Amsterdam ; ; New York, : Excerpta Medica, 1979
• ISBN: 0-470-71541-3; 0-470-71510-3
• Descrizione fisica: 1 online resource (392 p.)
• Collana: Ciba Foundation symposium ; ; 65 (new ser.)
• Disciplina: 574.1/921
• Soggetti: Active oxygen in the body; Active oxygen - Toxicology; Pathology, Cellular; Radicals (Chemistry) - Physiological effect
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Oxygen Free Radicals and Tissue Damage; Contents; Chairman's introduction; The chemistry of dioxygen and its reduction products; Discussion; Hydroxyl radicals and biological damage in uitro: what relevance in uivo?; Discussion; Reaction rates of superoxide radicals with the essential amino acids; Discussion; Formation of copper-superoxide complexes; Interactions between iron metabolism and oxygen activation; Discussion; Superoxide dismutases: defence against endogenous superoxide radical; Discussion; Glutathione peroxidase: fact and fiction; Discussion; Biosynthesis of prostaglandins; DiscussionMechanisms of protection against the damage produced in biological systems by oxygen-derived radicals; Discussion; Zinc and NADPH-oxidation-dependent lipid peroxidation; Caeruloplasmin and serum antioxidant activity; Inflammatory cells and zinc; Lipid peroxidation: detection in viuo and in vitro through the formation of saturated hydrocarbon gases; Discussion; Dioxygen and the vitamin K-dependent synthesis of prothrombin; Discussion; Specific induction of pulmonary indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide; Discussion; Oxygen consumption by stimulated human neutrophilsDiscussion; Defects in the oxidative killing of microorganisms by phagocytic ; leukocytes; Discussion; The role of myeloperoxidase in the microbicidal activity of polymorphonuclear leukocytes; Discussion; Fertilization of sea urchin eggs; The lactoperoxidase-thiocyanate-hydrogen peroxide antibacterium system; The pulmonary and extrapulmonary effects of ozone; Discussion; The pathology and biochemistry of paraquat; Discussion; Phagocyte-produced free radicals: roles in cyto- toxicity and inflammation; Discussion; GENERAL DISCUSSION; Carbonyl groups and carcinogenesisThe identity of the superoxide radical anion species; Closing remarks; Index of contributors; Subject index