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UNINA9910639877503321 |
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Autore |
Macheras P (Panos) |
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Titolo |
Revising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept / / Panos Macheras and Athanasios A. Tsekouras |
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Pubbl/distr/stampa |
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Cham, Switzerland : , : Springer, , [2023] |
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©2023 |
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ISBN |
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Descrizione fisica |
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1 online resource (137 pages) |
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Disciplina |
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Soggetti |
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Drugs - Bioavailability |
Drugs - Absorption and adsorption |
Oral medication |
Pharmacokinetics |
Biological Availability |
Biopharmaceutics |
Drug Therapy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Intro -- Foreword -- Preface -- Contents -- Part I: Oral Pharmacokinetics -- Chapter 1: From Bateman (1910) to Dost (1953) -- 1.1 Harry Bateman: First-Order Kinetics in Physics (1910) -- 1.2 Friedrich Hartmut Dost: First-Order Kinetics in Pharmacokinetics (1953) -- 1.3 Simulations Based on Bateman´s Equation -- 1.4 The Fundamental Metrics of Bioavailability/Bioequivalence Studies -- References -- Chapter 2: The Unphysical Hypothesis of Infinite Absorption Time -- 2.1 The Biopharmaceutical-Pharmacokinetic Basis of the Bateman Equation -- 2.2 State of the Art in Oral Drug Absorption -- 2.2.1 The PK Route -- 2.2.1.1 Questioning the Absorption Rate Constant, ka -- 2.2.1.2 PBPK Models -- 2.2.2 The Bioph Route -- 2.2.3 The Absorption Rate Constant (ka) Links the Bioph and PK Routes -- 2.3 The Unphysical Hypothesis of Infinite Absorption Time -- 2.4 Concluding Remarks -- References -- Chapter 3: The Finite Absorption Time (FAT) Concept -- 3.1 Sink Conditions Imply Zero-Order Kinetics |
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