Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19 / / by Wan Gi Byun

• Record Nr.: UNINA9910635394703321
• Autore: Byun Wan Gi
• Pubbl/distr/stampa: Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
• ISBN: 9789811978142; 9789811978135
• Edizione: [1st ed. 2023.]
• Descrizione fisica: 1 online resource (156 pages)
• Collana: Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5061
• Disciplina: 362.1962414
• Soggetti: Bioengineering; Biotechnology; Biophysics; Protein folding; RNA interference; Biological and Physical Engineering; Chemical Bioengineering; Protein Folding; RNA Interference
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"
• Nota di contenuto: 1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.
• Sommario/riassunto: This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA ; interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.