Environmental science Nano

• Record Nr.: UNINA9910132359403321
• Pubbl/distr/stampa: Cambridge, UK : , : Royal Society of Chemistry, , [2014]-
• ISSN: 2051-8161
• Descrizione fisica: 1 online resource
• Disciplina: 620.505
• Soggetti: Environmental sciences; Nanotechnology; Periodicals.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Periodico
• Note generali: Refereed/Peer-reviewed

DNA-Encoded Libraries / / edited by Andreas Brunschweiger, Damian W. Young

• Record Nr.: UNINA9910632474303321
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
• ISBN: 3-031-18629-X
• Edizione: [1st ed. 2022.]
• Descrizione fisica: 1 online resource (280 pages)
• Collana: Topics in Medicinal Chemistry, , 1862-247X ; ; 40
• Disciplina: 929.605; 615.19
• Soggetti: Pharmaceutical chemistry; Physical biochemistry; Biology - Technique; Biophysics; Proteins; Medicinal Chemistry; Biophysical Chemistry; Biophysical Methods; Protein Biochemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry. .
• Sommario/riassunto: This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.