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Record Nr. |
UNINA9910632474303321 |
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Titolo |
DNA-Encoded Libraries / / edited by Andreas Brunschweiger, Damian W. Young |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
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ISBN |
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Edizione |
[1st ed. 2022.] |
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Descrizione fisica |
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1 online resource (280 pages) |
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Collana |
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Topics in Medicinal Chemistry, , 1862-247X ; ; 40 |
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Disciplina |
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Soggetti |
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Pharmaceutical chemistry |
Physical biochemistry |
Biology - Technique |
Biophysics |
Proteins |
Medicinal Chemistry |
Biophysical Chemistry |
Biophysical Methods |
Protein Biochemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry. . |
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Sommario/riassunto |
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This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a |
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