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1. |
Record Nr. |
UNINA9910627498603321 |
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Autore |
Balcerowicz, Leszek |
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Titolo |
Il fallimento degli stati sovrani nell'Unione europea : una prospettiva comparata = = Sovereign bankruptcy in the European Union : a comparative perspective / Leszek Balcerowicz ; prefazione di = foreword by Nicola Rossi ; commenti di = comments by Carlo Cottarelli, Ignazio Visco |
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Pubbl/distr/stampa |
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Torino, : IBL Libri, 2010 |
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ISBN |
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Descrizione fisica |
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Collana |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNISA996218619503316 |
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Titolo |
Analysis of drug impurities [[electronic resource] /] / edited by Richard J. Smith and Michael L. Webb |
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Pubbl/distr/stampa |
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Oxford ; ; Ames, Iowa, : Blackwell, 2007 |
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ISBN |
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1-281-32024-2 |
9786611320249 |
0-470-98874-6 |
0-470-99422-3 |
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Descrizione fisica |
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1 online resource (290 p.) |
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Collana |
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Analytical chemistry series |
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Altri autori (Persone) |
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SmithRichard J |
WebbMichael L |
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Disciplina |
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Soggetti |
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Drugs - Analysis |
Materia medica |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Analysis of Drug Impurities; Contents; Preface; List of contributors; 1 Organic impurities in drug substance: origin, control, and measurement; 1.1 Introduction; 1.2 Origin of impurities; 1.2.1 Process impurities; 1.2.2 Degradation impurities; 1.2.3 Contamination impurities; 1.2.4 Other impurities; 1.3 Control of drug substance impurities; 1.3.1 Control of residual solvents; 1.3.2 Control of synthetic impurities; 1.3.3 Control of impurities in biological and botanical products; 1.3.4 Purification processes; 1.3.5 Control of impurities from packaging; 1.3.6 Control of contamination impurities |
1.3.7 Control of degradants on stability1.4 Measurement of drug substance impurities; 1.4.1 HPLC; 1.4.2 GC; 1.4.3 CE; 1.4.4 General considerations; 1.5 Conclusions; Disclaimer; References; 2 Organic impurities in drug products: origin, control and measurement; 2.1 Introduction; 2.2 Analytical methodology; 2.3 Drug-excipient compatibility experimental design; 2.4 Degradation mechanisms; 2.5 Excipients' role in drug product destabilisation; 2.6 Processing as a source of moisture; 2.7 Hydrolysis; 2.8 Oxidation; 2.9 Photolysis; 2.10 |
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Impact of processing on photostability |
2.11 Miscellaneous reactions2.12 Container-closure systems; References; 3 Stereochemical impurities; 3.1 Introduction; 3.2 Separation techniques: direct resolution; 3.2.1 HPLC using CSPs; 3.2.2 HPLC using chiral mobile-phase additives; 3.2.3 Capillary electrophoresis using chiral selectors; 3.2.4 Supercritical fluid chromatography using chiral stationary phases; 3.2.5 Gas chromatography using chiral stationary phases; 3.3 Separation techniques: indirect resolution; 3.4 Non-separation techniques; 3.4.1 Chiroptical spectroscopy; 3.4.2 Nuclear magnetic resonance spectroscopy; 3.5 Conclusions |
AcknowledgementsReferences; 4 Low-level measurement of potent toxins; 4.1 Introduction; 4.2 Classes of genotoxic impurity; 4.2.1 Alkylating agents; 4.2.2 Reactive amines; 4.2.3 Fused tricyclics; 4.2.4 Substituted purines and pyrimidines; 4.2.5 Hydroperoxides; 4.3 The analytical challenge of genetic; 4.4 Gas chromatography; 4.4.1 Sample introduction techniques; 4.4.2 Detectors; 4.5 High-performance liquid chromatography; 4.5.1 Separation modes; 4.5.2 Detection techniques; 4.6 Supercritical fluid chromatography; 4.7 Thin-layer chromatography; 4.8 Sample pre-concentration |
4.8.1 Liquid-liquid extraction4.8.2 Solid-phase extraction; 4.8.3 Solid-phase microextraction; 4.8.4 Liquid-phase microextraction; 4.9 Other techniques; 4.9.1 Electrochemical measurements; 4.9.2 Derivatisation methods; 4.10 Adapting analytical methods from fields beyond pharmaceuticalsimpurities analysis; 4.10.1 Antineoplastic agents; 4.10.2 Other fields; 4.11 Validation of trace analytical methods; 4.11.1 Sensitivity; 4.11.2 Specificity; 4.11.3 Accuracy; 4.11.4 Solution stability; 4.11.5 Linearity and precision; 4.12 Conclusions; References; 5 A systematic approach to impurity identification |
5.1 Introduction |
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Sommario/riassunto |
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A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.Written for both practic |
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3. |
Record Nr. |
UNINA9910785712203321 |
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Autore |
Lakos William |
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Titolo |
Chinese ancestor worship [[electronic resource] ] : a practice and ritual oriented approach to understanding Chinese culture / / by William Lakos |
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Pubbl/distr/stampa |
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Newcastle upon Tyne, : Cambridge Scholars Pub., 2010 |
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ISBN |
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Descrizione fisica |
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1 online resource (159 p.) |
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Disciplina |
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Soggetti |
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Ancestor worship - China |
Religion and culture - China |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. [137]-144) and index. |
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Nota di contenuto |
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Introduction. A new approach to understanding Chinese culture -- Watching the ancestors -- Mind-ing the ancestors -- Living with the ancestors: filial piety -- Two concepts of ritual and two understandings of 'Li' -- Challenging the master narrative 'Confucianism-as-Chinese culture' -- Conclusion and consequences. |
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Sommario/riassunto |
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This book is a new approach to how we in the West understand China and Chinese culture. It challenges the master narrative of Confucianism and shows that ancestor worship has underpinned Chinese culture in many influential and vital ways and provides a nuanced and more efficacious paradigm through which Chinese culture may be viewed.It is an exposition and analysis of Chinese ancestor worship and its correlations, especially filial piety and ritual, and it shows the intrinsic importance of ancestor worship to Chinese culture. By using a practice theory—ritual—and communication theory approach this work highlights the relationship between the rituals of ancestor worship and their meaning within Chinese culture. In emphasizing the efficacy of ritual to cultural meaning it also questions and compares the master narrative of Confucianism in its role as the prime cultural symbol and paradigm of Chinese culture. China and Chinese culture is conventionally understood by the West through the paradigm and its articulated discourse of Confucianism. In order to ameliorate and overcome the epistemological problematic of a cross-cultural |
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understanding of China, a new approach to the understanding of China and Chinese culture is proposed. The thesis approach is ‘meta-disciplinary’ and multi-viewed, and draws on a range of evidence and theories which focus on the problematic of ‘cross-cultural understanding.’ |
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