Mismatch repair deficient cancers diagnosis, treatment and prevention / / John Burn

• Record Nr.: UNINA9910596997903321
• Autore: Burn John, MD, MRCP
• Pubbl/distr/stampa: London, : Henry Stewart Talks, 2014
• Descrizione fisica: 1 online resource (1 streaming video file (44 min.) : color, sound)
• Collana: Molecular genetics of human disease, , 2056-452X
• Soggetti: Aspirin; Cancer - Genetic aspects; Colon (Anatomy) - Cancer - Genetic aspects; Colon (Anatomy) - Cancer - Treatment; Medical genetics; Molecular genetics; Rectum - Cancer - Genetic aspects; Rectum - Cancer - Treatment; Aspirin - therapeutic use; Biomarkers; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - therapy; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; Genetics, Medical; Microsatellite Instability; Microsatellite Repeats
• Lingua di pubblicazione: Inglese
• Formato: Videoregistrazione
• Livello bibliografico: Monografia
• Note generali: Animated audio-visual presentation with synchronized narration.; Title from title frames.
• Nota di contenuto: Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic ; pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.