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1. |
Record Nr. |
UNINA9910214936903321 |
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Autore |
Bour Isabelle |
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Titolo |
Bonds of Union : Practices and Representations of Political Union in the United Kingdom (18th-20th centuries) / / Isabelle Bour, Antoine Mioche |
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Tours, : Presses universitaires François-Rabelais, 2017 |
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ISBN |
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Descrizione fisica |
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1 online resource (206 p.) |
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Altri autori (Persone) |
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BrownStewart J |
ClarkJ. C. D |
CraigCairns |
FosterRoy |
GravesMatthew |
MiocheAntoine |
PelletierMartine |
TierneyStephen |
BourIsabelle |
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Soggetti |
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History |
Political Science Public Admin. & Development |
Grande-Bretagne |
politique |
gouvernance |
représentation |
Great Britain |
politics |
representation |
governance |
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Materiale a stampa |
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Monografia |
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The appearance and development of a "Four Nations" slant on British history over the last two decades has in many ways pointed up "the Union" as an essential component of the national history or histories of |
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the British Isles. "Four Nations" historians, however, have tended to focus exclusively on the United Kingdom as the core of either a nascent or a now defunct Empire. History is variously invoked to account for the emergence of the British dynastic state, explain its (to some) puzzling endurance, and not infrequently to assert or at least suggest its necessary demise in a world of nation states. By stressing the need for a multi-contextual approach, and casting union strictly as a process—something that is either in the making, or unravelling—"Four Nations" historians have thus paradoxically obscured the fact that union has served for several centuries to conceptualise and accommodate diversity in unity, not just in Britain, but in the wider British world. The essays in this volume, originally presented in June 2003 at a conference hosted by the University of Tours, therefore seek to move beyond the simplistic historiographical and political alternatives of union and dis-union to treat both the Union and union more generally as cultural as well as constitutional and historical constructs, well calculated to articulate separateness and help people make sense both of themselves and of their differences. Union is here approached from three key directions—the Churches, the Nation and the Constitution, all central since the seventeenth century to the question of unity and regional/national identities in the British metropole and Empire—and from three complementary angles—historical, legal and literary. From this perspective, it is hoped that union will be seen to provide a key to a fuller and more balanced, if not uncritical, understanding of a metropolitan and imperial British world of overlapping and sometimes conflicting national self-perceptions. |
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2. |
Record Nr. |
UNINA9910149179503321 |
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Autore |
The Associated Press The Associated |
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Titolo |
Candidate Hillary : From Senator to Presidential Hopeful |
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Pubbl/distr/stampa |
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New York : , : Diversion Publishing Corp., , 2002 |
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©2002 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (205 pages) |
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Hillary is up in the polls Hillary is down in the polls She's a feminist and women love her; she's an enabler and women hate her. She's brilliant and hardworking; she's entitled and untrustworthy. Sounds like Hillary Rodham Clinton's 2016 or even 2008 presidential campaign, right? Well, go back even farther to the year 2000 to discover how every one of those phrases was uttered during Hillary's very first campaign when she made history as the only first lady to ever run for office. That groundbreaking bid for U.S. Senate in New York made headlines around the world, coming as it did on the heels of her husband's scandalous affair with a White House intern. Reporter Beth J. Harpaz was there, covering this political whirlwind for The Associated Press, and her book, "Candidate Hillary," previously published as "The Girls in the Van," revisits every key moment of the race. This funny, fascinating account puts you in the press van that followed Hillary from Buffalo to Brooklyn as she fought a cast of familiar characters, including New York's pugnacious Mayor Rudy Giuliani. It's filled with all the successes and missteps, the kind that plagued the assumed front-runner's 2008 campaign for the Democratic presidential nomination, which instead went to a young Senator from Illinois named Barack Obama. Now, updated with new perspectives from the author and an introduction by National Politics Reporter Lisa Lerer, "Candidate Hillary" offers a window |
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into Hillary's vulnerabilities, strengths and the inner workings of the Clinton machine, all told with authority, humor and the benefit of hindsight. |
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3. |
Record Nr. |
UNINA9910595078103321 |
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Autore |
Dey Nandini |
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Titolo |
Precision Medicine in Solid Tumors |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (304 p.) |
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Soggetti |
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Medicine and Nursing |
Oncology |
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In the era of precision medicine, the use of molecularly targeted therapies in selected patients has led to a paradigm change in cancer treatment. Multiple studies have demonstrated the benefits of therapies that are chosen based on the molecular profile of the tumor and also from the liquid biopsy. With genomics' increasing ability, a routine transcriptomics analysis of advanced/metastatic cancers is now feasible in most cancer hospitals, including community cancer centers. This is an unprecedented shift in the management of cancers irrespective of their organ types, which not only improved the outcome but also opened several new avenues in research and practice, such as immune-check-point inhibitors, tumor-TME co-evolution in the development of resistance, longitudinal liquid biopsies, biomarkers screening and the management of electronic medical records.This book brings together these crucial areas of investigation. The research presented here attempts to address the current issues to provoke thoughts for the future. The future of precision medicine will have to embrace a shift from in vitro, in vivo/PDX models for the mechanistic study to a more |
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functional test based on the scientific interrogation of genomic data, in the form of functional precision medicine. We will also have to combat the element of noise in the multitudes of data and impart the regulatory structure to make judicious use of the data. The expectations for functional precision medicine are high. We aspire to witness a tremendous improvement in patient outcomes, from better to best, down the road that will match the clinical guidelines. |
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