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Record Nr. |
UNINA9910590074503321 |
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Autore |
Charles Wendy |
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Titolo |
Blockchain in life sciences / / Wendy Charles |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , [2022] |
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©2022 |
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ISBN |
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9789811929762 |
9789811929755 |
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Descrizione fisica |
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1 online resource (349 pages) |
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Collana |
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Disciplina |
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Soggetti |
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Blockchains (Databases) |
Life sciences - Data processing |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- About the Editor -- Abbreviations -- List of Figures -- List of Tables -- Blockchain Uses and Real World Evidence -- Introduction to Blockchain -- 1 Introduction -- 2 Blockchain Core Characteristics -- 2.1 Ledgers -- 2.2 Cryptography -- 2.3 Immutability (Tamper Evidence and Tamper Resistance) -- 2.4 Distribution -- 3 Blockchain Features -- 3.1 Permissionless Versus Permissioned -- 3.2 Permissionless -- 3.3 Off-Chain Versus On-Chain Storage -- 3.4 Smart Contracts -- 4 Blockchain Benefits for Life Sciences -- 4.1 Trust -- 4.2 Audit Trails-Provenance -- 4.3 Data Transparency Versus Privacy -- 4.4 Security -- 4.5 Performance -- 5 Conclusions -- 6 Key Terminology and Definitions -- References -- Blockchain in Pharmaceutical Research and the Pharmaceutical Value Chain -- 1 Brief Overview of Pharmaceutical Research -- 1.1 Drug Delivery and Discovery -- 1.2 Challenges Associated with Drug Delivery and Discovery -- 1.3 Challenges Associated with Preclinical (i.e., In Vitro, In Vivo) and Phase 0/I-IV Studies -- 2 Introduction of the End-To-End Pharmaceutical Value Chain -- 2.1 Five Main Categories: (1) Research and Discovery, (2) Clinical Development, (3) Manufacturing and Supply Chain, (4) Launch and Commercial Considerations, and (5) Monitoring and Health Records -- 2.2 Differentiating Pharmaceutical Value Chain |
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from Pharmaceutical Supply Chain -- 3 Blockchain Efforts Within Pharmaceutical Industry -- 3.1 Pharmaceutical Users Software Exchange (PhUSE) Blockchain Project -- 3.2 Innovative Medicines Initiative (IMI) Blockchain-Enabled Healthcare -- 3.3 The MELLODDY Project and Millions of Molecules Blockchain + Smart Contracts for Human Participant Regulations and Consent Management -- 3.4 Information Exchange and Data Transformation (INFORMED) Initiative -- 3.5 Moneyball Medicine. |
4 Mapping Blockchain Characteristics to Pain Points in the Pharmaceutical Value Chain -- 4.1 Adapted Fit-For-Purpose Framework and Design Elements -- 4.2 Matching Characteristics (e.g., Decentralized, Distributed, Conditionally Immutable, Scalable, Cryptographically Secured) to Identified Pain Points in Each of the 5 Categories -- 5 Blockchain-But Not in a Vacuum -- 5.1 Blockchain-Complementary Established and Emerging (e.g., Machine Learning, Artificial Intelligence) Technologies for the Pharmaceutical Value Chain -- 6 Debunking Myths Around Challenges with Blockchain -- 6.1 The Myth of the Technical Challenge -- 6.2 The Reality of Challenges Tied to Change Management, Resource Allocation, Paradigm Shift, and Reaching Consensus -- 7 Blockchain and The Idea Pipeline -- 7.1 Pharmacogenomics -- 7.2 Collaborative Pharmaceutical Development -- 7.3 Patient Access, Medication Reclamation, and Prescription Waste Reduction -- 7.4 The Evolution of the Traditional Retail Pharmacy -- 8 Future Directions -- 9 Conclusions -- References -- Blockchain-Based Scalable Network for Bioinformatics and Internet of Medical Things (IoMT) -- 1 Introduction -- 1.1 Data Ownership -- 1.2 Data in Blockchain-Based Network -- 2 Case Implementation of Internet of Medical Things (IoMT) with Real Ownership -- 2.1 The Synsal Network -- 2.2 Sensors, Device Engineering, and Scaling in the Synsal Network -- 3 Tokenization and Value Scaling in the Blockchain-Based Network of Hardware Devices -- 3.1 Tokenization and Value Scaling -- 3.2 Basic Stabilization Tokenomics -- 4 Future Directions -- 5 Conclusions -- References -- Blockchains and Genomics: Promises and Limits of Technology -- 1 Introduction: A Brief History of Capitalization on Genes -- 2 The Scientific and Market Value of Genomic Data -- 2.1 On the Nature of Data, and the Data of Nature -- 2.2 Fair and Sustainable Data Use. |
3 Democratize, Decentralize, and Disintermediate Data (The Three Ds) -- 3.1 Blockchain Genomics: The Current Slate -- 4 Why Genomes Cannot Be Owned -- 5 How Shall We Treat Genes? -- 6 What About Non-Fungible Tokens, NFTs? -- 6.1 The Need for Regulation -- 7 Future Directions -- 8 Conclusions -- References -- Convergence of Blockchain and AI for IoT in Connected Life Sciences -- 1 Introduction -- 1.1 Fueling the Digital Transformation in Health and Life Sciences -- 1.2 Technology Unification -- 2 Harnessing the Power of Data-Driven Technologies in Life Sciences -- 2.1 Data-Driven Technologies in Life Sciences -- 3 Innovating in a Highly Regulated Industry -- 4 Essential Elements for Data Strategy in Life Sciences -- 4.1 Data Building Blocks -- 5 Prioritizing Risk Management in Life Sciences -- 6 Opportunities and Challenges for Emerging Digital Technologies in Life Sciences -- 6.1 Major Milestones in Life Sciences Product Development -- 7 Strategic Planning Frameworks -- 7.1 Blockchain and AI to Mitigate Risks of IoT/BYOD -- 7.2 Blockchain-AI Platforms and Infrastructures -- 8 Future Directions -- 8.1 Human as a Platform -- 8.2 Thinking Beyond the Adoption of Technology -- 9 Conclusions -- References -- A Blockchain-Empowered Federated Learning System and the Promising Use in Drug Discovery -- 1 Introduction -- 2 Overview of Federated Learning and Blockchain -- |
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2.1 Federated Learning -- 2.2 Barriers and Challenges in Drug Discovery -- 2.3 Challenges in Federated Learning -- 2.4 Blockchain Benefit for Federated Learning -- 2.5 The Benefits of Blockchain-Empowered Federated Learning for Drug Discovery -- 3 The Rahasak-ML Platform -- 3.1 Overview -- 3.2 Key Components -- 4 Rahasak-ML Federated Learning Process -- 4.1 Overview -- 4.2 Incremental Training Flow -- 4.3 Finalizing Model. |
4.4 The Use Case of Blockchain-Empowered Federated Learning in the Medical Field -- 5 Future Directions -- 5.1 Data Heterogeneity -- 5.2 Efficiency and Effectiveness -- 5.3 Model Interpretation -- 6 Conclusions -- References -- Considerations for Ensuring Success of Blockchain in Life Sciences Research -- Valuing Research Data: Blockchain-Based Management Methods -- 1 Introduction -- 1.1 Nature of Health Data -- 1.2 Health Data Management -- 2 Data as an Asset -- 2.1 How to Value Data Assets -- 3 Data Sales Methods -- 3.1 Data Brokers -- 3.2 Centralized Data Marketplaces -- 3.3 Decentralized Data Marketplaces -- 3.4 Non-Fungible Tokens -- 4 Considerations -- 4.1 Ethical Considerations -- 4.2 Ownership -- 4.3 Data Considerations -- 5 Recommendations -- 5.1 Ethical Recommendations -- 5.2 Data Recommendations -- 5.3 Legal Recommendations -- 6 Future Directions -- 6.1 Regulations -- 6.2 Future Research -- 7 Conclusions -- 7.1 Key Terminology and Definitions -- References -- Blockchain Adoption in Life Sciences Organizations: Socio-organizational Barriers and Adoption Strategies -- 1 Introduction -- 2 Background Literature -- 3 Research Methods -- 4 Findings -- 4.1 The State of the Blockchain + Life Sciences Ecosystem -- 4.2 Socio-organizational Barriers for Blockchain Adoption in Life Sciences -- 4.3 Barrier 4: The Lack of an "Ecosystem" Mindset -- 4.4 Adoption Strategies -- 5 Discussion -- 5.1 Limitations and Future Directions -- 6 Conclusion -- References -- Blockchain Governance Strategies -- 1 Introduction -- 2 Defining Governance -- 3 A Deeper Dive: Blockchain Governance -- 3.1 On-Chain Governance -- 3.2 Off-Chain Governance -- 4 Types of Ecosystem Governance Decisions -- 5 Common Blockchain Governance Strategies -- 5.1 Founder Led/Benevolent Dictator -- 5.2 Core Development Team -- 5.3 Federations or Alliances -- 6 Ecosystem Roles. |
7 Typical Ecosystem for Life Sciences Blockchain -- 7.1 Special Considerations for Life Sciences -- 8 Recommendations -- 9 Future Directions -- 10 Conclusions -- References -- Life Sciences Intellectual Property Through the Blockchain Lens -- 1 Introduction -- 2 The Emergence of Blockchain in Life Sciences -- 3 The Intersection of Blockchain and Life Sciences IP Rights in the United States -- 3.1 Patents -- 3.2 Trademarks and Trade Dress -- 3.3 Trade Secrets -- 3.4 Copyrights -- 4 Transferring IP Rights Through Blockchains -- 5 Managing IP Rights Through Blockchain -- 6 Blockchain in Adversarial Proceedings Involving IP Rights -- 6.1 Anticounterfeiting -- 7 Future Directions -- 8 Conclusions -- References -- Regulatory Compliance Considerations for Blockchain in Life Sciences Research -- 1 Introduction -- 1.1 Regulatory Agency Uses of Blockchain -- 1.2 Regulatory Applicability -- 2 Regulatory Review and Documentation -- 2.1 System Design and Documentation -- 2.2 System Protection Features -- 2.3 Record and Signature Integrity -- 2.4 Verification and Validation -- 2.5 Training -- 3 Outsourcing -- 4 Future Directions -- 4.1 Standards -- 4.2 Blockchain Education -- 4.3 Research -- 5 Conclusions -- 5.1 Key Terminology and Definitions -- References -- The Art of Ethics in Blockchain for Life Sciences -- 1 Introduction -- 2 Digital Ethics Programs Design for Blockchain in Life Sciences -- 2.1 General Application of Digital Ethics Across the Life Sciences |
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Continuum -- 2.2 Research -- 2.3 Genomics and Precision Medicine -- 2.4 Digital Identity -- 3 Cultural, Legal, and Socioeconomic Influences -- 4 Blockchain Ethics and Purpose in Life Sciences -- 5 Future Directions: Disruption, Innovation, Evolution -- 6 Conclusions -- References -- Cybersecurity Considerations in Blockchain-Based Solutions -- 1 Introduction -- 2 Blockchain Solution Architecture. |
2.1 Network and Architecture Types. |
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2. |
Record Nr. |
UNINA9910795223303321 |
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Autore |
Porter Julian |
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Titolo |
149 paintings you really need to see in North America : (so you can ignore the others) / / Julian Porter, Stephen Grant |
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Pubbl/distr/stampa |
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Toronto [Ontario] : , : Dundurn, , 2017 |
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©2017 |
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ISBN |
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1-4597-3936-1 |
1-4597-3937-X |
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Descrizione fisica |
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1 online resource (373 pages) : illustrations (some color), photographs |
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Disciplina |
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Soggetti |
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Painting, European |
Painting - Appreciation |
Art museums - United States |
Art museums - Canada |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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1. The Presentation of the Christ Child in the Temple (c. 1320) / Giotto (Giotto di Bondone -- 2. El Jaleo (The Ruckus) 1882 / John Singer Sargent -- 3. Europa (1559-62); Gentile Bellini (1429-1507; A Seated Scribe (1479-81) / Titian (Tiziano Vecellio) -- 4. Moonlit Landscape (1819) / Washington Allston -- Watson and the Shark (1778) / John Singleton Copley -- Edmondo and Therese Morbilli (c. 1865) / Edgar Degas -- 7. Fray Hortensio Felix Paravicino (1609) / El Greco (Domenikos Theotokopoulos) -- 8. The Dead Christ with Angels (c. 1524-27) / Rosso Fiorentino (Giovanni Battista di Jacopo) -- 9. Susie (1988) / Lucian Freud -- 10. Where Do We Come From? What Are We? |
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Where Are We Going? (1897-98) / Paul Gauguin (1848-1903) -- 11. The Daughters of Edward Darley Boit / John Singer Sargent (1856-1925) -- 12. Slave Ship (Slavers Throwing Overboard the Dead and Dying, Typhoon Coming On (1840) / Joseph Mallord William Turner -- Luis de Gongora y Argote (1622) / Velazquez (Diego Rodriguez de Silva y Valazquez) -- 13. Gotham News (1955) / Willem de Kooning -- Six in Vermilion with Red in Red (1970) / Patrick Heron -- 15. Earthly Paradise (1916-20) / Pierre Bonnard -- 16. Still Life with Fruits and Stringed Instrument (1938) / Georges Braque -- 17. Paris Street, Rainy Day (1877) / Gustave Caillebotte -- 18. White Crucifixion (1938) / Marc Chagall -- 19. The Beheading of Saint John the Baptist (1455-60) / Giovanni di Paolo -- The Feast in the House of Simon (1608-14) / El Greco (Domenikos Theotokopoulos) -- 20. Nighthawks (1942) / Edward Hopper -- Jesus Mocked by the Soldiers (1865) / Edouard Manet -- Untitled #12 (1977) / Agnes Martin -- 22. City Landscape (1955) / Joan Mitchell -- 23. Woman at Her Toilette (1875-80) / Berthe Morisot -- Ascending and Descending Hero (1965) / Bridget Riley -- A Sunday Afternoon on the Island of La Grande Jatte, 1884 (1884-86) / Georges Seurat -- 25. Tarquin and Lucretia (1578-80) / Tintoretto (Jacopo Robusti) -- 26. Equestrienne (At the Cirque Fernando) (1887-88) / Henri de Toulouse-Lautrec -- Fishing Boats with Hucksters Bargaining for Fish (1837-38) / Joseph Mallord William Turner -- 27. The Bedroom (1889) / Vincent van Gogh -- 28. American Gothic (1930) / Grant Wood -- 29. Study for a Portrait (1949) / Francis Bacon -- 30. Paul III (1996) / Chuck Close -- Eiffel Tower (1924) / Robert Delaunay -- 32. Persian Letters (1958) / Rene Magritte -- 33. The Wedding Dance (c. 1566) / Pieter Bruegel the Elder -- 24. The Detroit Industry Murals (1932-33) / Diego Rivera -- Gamblers Quarreling (c. 1665) / Jan Steen -- The Jewish Cemetery (1654-55) / Jacob Isaacksz van Ruisdael -- Nocturne in Black and Gold, the Falling Rocket (1875) / James Abbott McNeill Whistler -- 36. Europe After the Rain (1940-42) / Max Ernst -- Still Life with Blue Pot (c. 1900-06) / Paul Cezanne -- The Musician's Brawl / Georges de La Tour -- Christ's Triumphant Entry into Brussels in 1889 (1888) / James Ensor -- 37. Bullfight, Suerte de Varas (1824) / Goya (Francisco de Goya) -- 38. The Rue Mosnier with Flags (1878) / Edouard Manet -- 39. Adoration of the Magi (c. 1495-1505) / Andrea Mantegna -- Rembrandt Laughing (c. 1628) / Rembrandt (Rembrandt van Rijn) -- 40. The Entombment (c. 1612) / Peter Paul Rubens -- 41. Bathsheba After the Bath (1670-75) / Jan Steen -- 42. Irises (1889) / Vincent Van Gogh -- 43. Flight (1952) / Hans Hofmann -- 44. Melodious (1924) / Wassily Kandinsky -- Painting with Troika (1911) / Wassily Kandinsky -- 45. Untitled (1984) / Jean-Michel Basquiat -- 46. Buttress (1956) / Franz Kline -- 47. St. Francis in the Desert (c. 1476-78) / Giovanni Bellini -- 48. The White Horse (1819) / John Constable -- 49. St. Jerome (1590-1600) / El Greco (Domenikos Theotokopoulos) -- St. John the Evangelist (c. 1454-69) / Piero della Francesca -- 50. The Forge / Goya (francisco de Goya) -- Portrait of a Man (c. 1660) / Frans Hals -- 51. Sir Thomas More (1527) / Hans Holbein the Younger -- 52. Julia, Lady Peel / Sir Thomas Lawrence -- 53. The Polish Rider (c. 1655) / Rembrandt (Rembrandt van Rijn) -- 54. Self-Portrait (1658) / Rembrandt (Rembrandt van Rijn) -- 55. The Portrait of a Man in a Red Cap (c. 1510) / Titian (Tiziano Vecellio) -- 56. King Philip IV of Spain (1644) / Velazquez (Diego Rodriguez de Silva y Velazquez) -- 57. Officer and Laughing Girl (c. 1657) / Johannes Vermeer -- 58. Blue Monochrome (1959) / Yves Klein -- Elegy to the Spanish Republic No. 110 (1971) / Robert Motherwell -- 60. Untitled (Violet, Black, Orange, Yellow on White and Red) (1949) / Mark Rothko -- The Annunciation (c. 1485-92) / Botticelli (Sandro Botticelli) -- 62. |
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Portrait of the Young Man (1530s) / Agnolo Bronzino -- 63. The Harvesters (1565) / Pieter Bruegel the Elder -- 64. The Denial of St. Peter (c. 1610) / Caravaggio (Michelangelo Merisi da Caravaggio) -- 65. The Death of Socrates (1787) / Jacques Louis David -- The Ballet from "Robert le Diable" (1871) / Edgar Degas -- The Champion Single Sculls (Max Schmitt in a Single Scull) (1871) / Thomas Eakins -- 68. View of Toledo (c. 1598-99) / El Greco (Domenikos Theotokopoulos -- 69. The Gulf Stream (1899) / Winslow Homer -- 70. Princesse de Broglie (1851-53) / Jean Auguste Dominique Ingres -- White Flag (1955) / Jasper Johns -- 71. Portrait of a Woman with a Man at a Casement (c. 1440) / Fra Filippo Lippi -- 72. Reclining Nude (1917) / Amedeo Modigliani -- 73. La Grenouillere (1869) / Claude Monet -- 74. Aristotle with a Bust of Homer (1653) / Rembrandt (Rembrandt van Rijn) -- 75. Self-Portrait (1660) / Rembrandt (Rembrandt van Rijn) -- |
76. The Three Judges (1913) / Georges Rouault -- Madame X (Madame Pierre Gautreau) (1883–84) / John Singer Sargent -- 77. The Capture of Carthage, 1725–29 / Tiepolo (Giovanni Battista Tiepolo) -- Francesco d'Este (c. 1460) / Rogier van der Weyden -- Lucas van Uffel (c. 1622) / Sir Anthony van Dyck -- The Crucifixion ; The Last Judgment (c. 1440-41) / Jan van Eyck -- 78. Wheat Field with Cypresses (1889) / Vincent van Gogh -- |
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Sommario/riassunto |
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"This essential companion to all the major North American museums and galleries highlights some of the world's greatest paintings, from Giotto to Robert Motherwell, on display across the U.S. and Canada. Julian Porter brings a passion for art that began with a seven-year stint as a student tour guide in Europe, followed by countless tours he has conducted at galleries in Europe and North America. His co-author, Stephen Grant, brings a wealth of expertise in the twentieth-century artists, and presents them within the framework of a North American-led, sustained burst of originality and shock. Presented with originality, wit, and irreverence to complement Julian and Stephen's comprehensive knowledge of the art world, here is the best that North American galleries have to offer. Focused and curated to give you everything you need to enjoy the greatest works of art in the best company, and save you the sore feet and superfluous information."-- |
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