Anhedonia

• Record Nr.: UNINA9910586591703321
• Autore: Pizzagalli Diego A
• Pubbl/distr/stampa: Cham : , : Springer International Publishing AG, , 2022; ©2022
• ISBN: 9783031096839; 9783031096822
• Descrizione fisica: 1 online resource (526 pages)
• Collana: Current Topics in Behavioral Neurosciences ; ; v.58
• Disciplina: 616.89
• Soggetti: Humor (Psicologia); Psiquiatria; Llibres electrònics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Intro -- Preface -- Contents -- Part I: Anhedonia - History, Etiology, and Assessments -- Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disorders -- 1 Introduction -- 2 Clinical Scales of Anhedonia and Reward Deficits: Beyond Pleasure and Interest -- 2.1 Early Measures (1970-2000) -- 2.2 Contemporary Measures (2001-2021) -- 2.3 Other Measures of Anhedonia -- 2.4 Gaps in Existing Anhedonia Clinical Scales -- 3 Preclinical and Clinical Reward Tasks -- 3.1 Anticipation -- 3.1.1 Preclinical -- 3.1.2 Clinical -- 3.2 Motivation and Effort Expenditure -- 3.2.1 Preclinical -- 3.2.2 Clinical -- 3.3 Valuation of Reward -- 3.3.1 Preclinical -- 3.3.2 Clinical -- 3.4 Expectation and Prediction Error -- 3.4.1 Preclinical -- 3.4.2 Clinical -- 3.5 Outcome and Consummatory Pleasure -- 3.5.1 Preclinical -- 3.5.2 Clinical -- 3.6 Reward Learning and Feedback Integration -- 3.6.1 Preclinical -- 3.6.2 Clinical -- 3.7 Translational Difficulties in Behavioral Assessments of Anhedonia -- 4 Conclusions -- References -- Developmental Trajectories of Anhedonia in Preclinical Models -- 1 The Concept of Anhedonia and Its Operationalization in Preclinical Models -- 1.1 Novel Tools for the Study of Anhedonia in Preclinical Models -- 1.2 The Reward Circuit and Its Study in Experimental Models -- 2 Anhedonia and Early-Life Adversity (ELA) -- 2.1 Why Study ELA ; and Anhedonia? The Human Landscape -- 2.2 What Is ELA and How Do We Model It? -- 2.3 Anhedonia Following ELA Involves a Developing Reward Circuit -- 2.4 Anhedonia After ELA: Manifestations and Sex Specificity -- 3 General Conclusions -- References -- Origins of Anhedonia in Childhood and Adolescence -- 1 Introduction -- 2 Impact of Positive Caregiving During Infancy -- 3 Impact of Memory Processes and Social Engagement During Early and Middle Childhood.; 4 Role of Self-Concept Development During Childhood and Adolescence on Anhedonia -- 5 Conclusions and Future Directions -- References -- Understanding Anhedonia from a Genomic Perspective -- 1 Introduction -- 2 Contemporary Psychiatric Genetics Frameworks: Relevance to RDoC -- 3 Genetic Studies of Anhedonia and Related Constructs -- 3.1 Twin and Family Studies -- 3.2 Candidate Gene Studies -- 3.3 GWAS -- 3.4 Polygenic Studies -- 4 Conclusions and Future Directions -- References -- Environmental Contributions to Anhedonia -- 1 Introduction -- 2 Definitional Issues: Consummatory vs. Motivational Anhedonia -- 3 Definitional Issues: Stress Exposure and Response -- 4 Relation of Stress to Reward Processing in the Preclinical Literature -- 4.1 Chronic Mild Stress -- 4.2 Acute Stress -- 4.3 Social Stress -- 4.4 Maternal Separation -- 4.5 Stress Response and Reward -- 4.6 Summary -- 5 Relation of Stress to Reward Processing in Humans -- 5.1 Proximal Stressful Life Events -- 5.2 Early Adversity and Maltreatment -- 5.3 Acute Laboratory Stress -- 5.4 Stress Response and Reward -- 5.5 Summary -- 6 Disclosures -- References -- Part II: Anhedonia in Psychiatric and Neurological Disorders -- Anhedonia in Depression and Bipolar Disorder -- 1 Introduction -- 2 History, Epidemiology, and Phenomenology of Anhedonia in Mood Disorders -- 2.1 Anhedonia as a Diagnostic Criterion for Depression -- 2.2 Epidemiology of Anhedonia in Mood Disorders -- 2.2.1 Prevalence of Anhedonia in Mood Disorders -- 2.2.2 Severity of Anhedonia Across Distinct Mood Disorder Diagnoses -- 2.3 Anhedonia Phenomenology -- 3 Clinical Significance of Anhedonia in Mood Disorders -- 3.1 Association with Illness Course -- 3.2 Association with Treatment Response -- 4 Neurobiology of Anhedonia in Mood Disorders -- 4.1 Neural Correlates of Reward Processing in MDD.; 4.1.1 Blunted Anticipation-Related Activation in the Ventral Striatum as a Trait-Like Feature of MDD -- 4.1.2 Disrupted Corticostriatal Activation to Reward Outcome (Consumption) in MDD -- 4.1.3 Disrupted Reward Prediction Errors in MDD -- 4.2 Neurobiology of Reward Processing in BD -- 4.2.1 Heightened Reward-Related Activation in the Lateral OFC Characterizes BD -- 4.2.2 Mixed Pattern of Striatal Activation in Response to Reward in BD -- 4.3 Differences in Reward-Related Brain Activation Between MDD and BD -- 5 Summary -- References -- Anhedonia in Schizophrenia -- 1 Anhedonia as a Cardinal Symptom of Schizophrenia -- 2 A Heuristic Model of the Motivation-Action-Outcome Pathway -- 3 Mechanisms -- 3.1 Initial Response to Reward -- 3.2 Reward Anticipation and Reinforcement Learning -- 3.2.1 Reward Anticipation -- 3.2.2 Reinforcement Learning and Prediction Error -- 3.3 Effort Valuation -- 3.4 Cognitive Control and Goal-Directed Action -- 4 Using Technology to Assess Anhedonia in Daily Life -- 4.1 Ecological Momentary Assessment -- 4.2 Mobile Sensing Applications -- 4.3 Deploying Experimental Tasks on Mobile Devices -- 5 Summary -- References -- Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders -- 1 Addiction, Hyperkatifeia, and Anhedonia: Definitions and Heuristic Framework -- 1.1 Addiction, Hyperkatifeia, Anhedonia, Negative Reinforcement, and Opponent Process -- 1.2 Learned Hyperkatifeia/Anhedonia and Conditioned Negative Reinforcement -- 2 Neurochemical Neurocircuitry ; Mediating Hyperkatifeia/Anhedonia -- 3 Crosstalk with Physical and Emotional Pain -- 4 Neurobiology of Conditioned Hyperkatifeia, Including Anhedonia -- 5 Hedonic Set Point: An Allostatic View -- References -- Anhedonia in Nicotine Dependence -- 1 Introduction -- 2 Neurobiological Overlaps of Nicotine Dependence and Anhedonia.; 3 Anhedonia and Nicotine Dependence Within the Frameworks of the NIMH Research Domain Criteria (RDoC) and the Situation by Tra... -- 3.1 Reward Responsiveness -- 3.1.1 Reward Anticipation -- 3.1.2 Initial Response to Reward -- 3.1.3 Reward Satiation and Habituation -- 3.2 Reward Learning -- 3.2.1 Probabilistic and Reinforcement Learning -- 3.2.2 Reward Prediction Error (RPE) -- 3.2.3 Habit -- 3.3 Reward Valuation -- 3.3.1 Probability/Reward (Ambiguity/Risk) of Reward -- 3.3.2 Delayed Reward Value -- 3.3.3 Effort to Obtain Reward -- 4 Summary: Toward a Situation x Trait Anhedonic Response (STAR) RDoC Framework for Understanding Nicotine Dependence -- References -- Anhedonia in Posttraumatic Stress Disorder: Prevalence, Phenotypes, and Neural Circuitry -- 1 Anhedonia: A Consequential Transdiagnostic Construct -- 2 Anhedonia in Posttraumatic Stress Disorder: Prevalence, Outcomes, and Theories -- 3 Altered Reward Processing and Circuitry in Posttraumatic Stress Disorder -- 4 Areas of Future Research -- References -- Anhedonia in Anxiety Disorders -- 1 Introduction -- 2 Anhedonia in Anxiety: Early Observations to Current Empirical Status -- 2.1 Reward Valuation -- 2.2 Reward Responsiveness -- 2.3 Reward Learning -- 3 Vulnerability and Amplifying Factors -- 3.1 Etiological Origins -- 3.2 Cognitive and Regulatory Anhedonia Amplifiers -- 4 A Functional Account of How Anhedonia Could Impede Recovery from Anxiety -- 4.1 Sacrificing Rewards Due to Costly Avoidance -- 4.2 Consequences of Diminished Responsiveness -- 4.3 Lessons from Positive Emotion Science -- 4.4 Anhedonia and Threat Reactivity in Analogue and Clinical Samples -- 5 Treatment Implications -- 5.1 Anhedonia as a Predictor of Treatment Response -- 5.2 Anhedonia as a Treatment Target to Improve Outcomes for Anxiety -- 6 Concluding Remarks -- References -- Anhedonia in Eating Disorders.; 1 Introduction -- 2 Clinical Presentation of Anhedonia in ED -- 2.1 Social Anhedonia -- 3 Anhedonia and Reward Processing in ED -- 3.1 Altered Sensitivity and Motivation to Pursue Reward in ED: Evidence from Subjective Measures -- 3.2 Altered Reward Responsiveness (Liking) and Anticipation (Wanting) in ED: Evidence of Altered Neurotransmitter Function -- 3.3 Altered Reward Responsiveness (Liking) and Anticipation (Wanting) in ED: Evidence from Task-Based Functional Neuroimaging ... -- 3.4 Altered Reward Learning in ED: Evidence from Neurocognitive and Neuroimaging Studies -- 4 Anhedonia in Animal Models of Disordered Eating -- 5 Future Research Directions and Implications for Treatment -- 6 Conclusion -- References -- Anhedonia and Hyperhedonia in Autism and Related Neurodevelopmental Disorders -- 1 The Social Motivation Theory of Autism -- 2 Translational Evidence of Impaired Motivational Responses in Autism -- 3 Neurobiological Mechanisms of Impaired Motivational Responses in Autism -- 4 Studying Motivational Responses in Syndromic Developmental Disorders Associated with Autism to Understand Idiopathic Autism -- 5 A New Nosology to Describe Motivational Impairments in Autism and Related Neurodevelopmental Disorders -- References -- Anhedonia in Neurodegenerative Diseases -- 1 Introduction -- 2 Parkinson´s Disease -- 2.1 Anhedonia and Its Relationship with Depression in Parkinson´s Disease -- 2.2 Anhedonia and Its Relationship to Apathy in Parkinson´s Disease -- 2.3 Treatment of Anhedonia in Parkinson´s Disease -- 3 Dementia with Lewy Bodies ; -- 4 Parkinson´s Plus Syndromes -- 5 Alzheimer´s Disease -- 6 Vascular Dementia -- 7 Frontotemporal Dementia -- 8 Amyotrophic Lateral Sclerosis -- 9 Huntington´s Disease -- 10 Conclusions -- References -- Part III: Reward Processing Systems in Anhedonia -- Pleasure, Reward Value, Prediction Error and Anhedonia.; 1 Introduction.
• Sommario/riassunto: Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia.Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to "dissect" anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.