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Record Nr. |
UNINA9910586580103321 |
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Titolo |
Blood substitutes and oxygen biotherapeutics / / edited by Henry Liu, Alan D. Kaye, and Jonathan S. Jahr |
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Pubbl/distr/stampa |
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Cham, Switzerland : , : Springer, , [2022] |
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©2022 |
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ISBN |
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Descrizione fisica |
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1 online resource (441 pages) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Intro -- Foreword -- Blood Substitutes and Oxygen Biotherapeutics -- Is the Final Destination in the Long, Winding, Bumpy Road Finally in Sight? -- Contents -- Contributors -- Part I: Transfusion: Science and Practice -- 1: Erythrocyte Transfusion: Brief History and Current Practice -- Introduction -- Milestones in Erythrocyte Transfusion -- Karl Landsteiner and Discovery of Major Blood Groups -- The Early Years of Transfusion: The First Milestone -- Karl Landsteiner -- Balancing the Risks and Benefits of Anemia and Transfusion: The Second Milestone -- The Risks of Anemia -- The Target Organs of Anemia-Induced Injury -- Benefits and Risks of Erythrocyte Transfusion -- The Benefits of Transfusion -- The Risks of Transfusion -- Transfusion Reactions -- Transfusion Transmitted Infectious (TTI) Pathogens -- Transfusion-Attributable Adverse Outcomes -- Transfusion Avoidance and Blood Conservation -- The Search for an Objective Transfusion "Trigger" -- The Transfusion Requirements in Critical Care (TRICC) Study -- Restrictive vs Liberal Transfusion in Cardiac Surgery -- Patient Blood Management -- Summary and Conclusions -- References -- 2: Oxygen and ATP: the Energy Economy of the Cell -- Introduction -- Oxygen -- Adenosine Triphosphate -- ATP Production: An Overview -- Oxygen Utilization: An Overview -- The Cell's Energy Economy -- Aerobic Respiration -- Glycolysis -- In Summary -- Exceptional Case: Glycolysis in the Erythrocyte -- The Krebs Cycle -- Overview -- Some Details -- |
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The Electron Transport Chain, Oxidative Phosphorylation -- Mitochondria -- Friend or Foe? -- The Energy Economy of Vital Organs -- The Heart -- The Brain -- Neurovascular Coupling -- Neurometabolic Coupling -- The Kidney -- The Liver -- Oxygen Sensing -- The Carotid Body Chemoreceptors -- HIF Mediators -- Cardiovascular System and Oxygen Supply Integration: The Role of NO. |
In Summary -- "Bad" Oxygen Species -- Summary and Conclusions -- References -- 3: Physiological Functions of Blood -- Introduction -- Hematopoiesis -- Basic Physiology of the Components of Blood -- Transport of Oxygen and Carbon Dioxide -- Transport of Hormones, Nutrients and Metabolic Waste -- Hemostasis and Coagulation -- Immune System -- Acid-Base Regulation -- Thermoregulation -- Regulation of Body Fluids -- Conclusion -- References -- 4: Hemoglobin: Physiology and Hemoglobinopathy -- Introduction -- Hemoglobin and Oxygen Binding Regulation -- Oxygen Binding -- 2,3-DPG -- Hemoglobinopathies -- Thalassemia Syndromes -- Sickle Cell Disease -- Summary -- References -- 5: The Global Burden of Anemia -- Introduction -- Anemia Development and Classification -- Health and Societal Implications of Anemia -- Summary -- References -- 6: Blood Component Therapy: The History, Efficacy, and Adverse Effects in Clinical Practice -- Introduction -- Red Cell Components -- Red Blood Cell Concentrates -- Collection and Processing -- Principles of Preservation -- RBC Storage Lesions -- Metabolic Impairment -- Oxidative Injury -- Membrane Asymmetry -- Vesiculation -- Decreased Deformability -- Physiological Considerations -- Hemolysis -- Oxygen Delivery -- Hemostasis and Thrombosis -- Immunomodulation -- Clinical Outcomes -- Component Therapy: All Things "Yellow" -- Plasma Transfusions -- The Origin of Plasmapheresis Leading to Fresh Frozen Plasma -- Cryoprecipitate -- Platelets -- Platelet Activation and Adherence -- References -- 7: Allogeneic Blood Transfusion: Complications and Side Effects -- Introduction -- Infectious Complications -- Human Immunodeficiency Virus -- Hepatitis C Virus -- Hepatitis B Virus -- Septic Transfusion Reactions -- Immune-Mediated Complications -- Hemolytic Transfusion Reaction -- Allergic/Anaphylactic Complications. |
Allergic Transfusion Reactions -- Anaphylactic Transfusion Reactions -- Febrile Transfusion Reactions -- Cardiac and Pulmonary Complications -- Transfusion Associated Circulatory Overload -- Transfusion Associated Acute Lung Injury -- Conclusion -- References -- 8: The Effects of Hemoglobin-Based Oxygen Carriers (HBOC) on the Microcirculation -- Background -- Effects on the Microcirculation: A Hamster Skinfold Study -- Effects on the Microcirculation: A Canine Bulbar Conjunctiva Study -- Discussion -- References -- 9: Nitric Oxide and Hemoglobin: Physiological Implications -- Introduction -- Nitric Oxide Cardiovascular Effects -- Nitric Oxide Vascular Effects -- Nitric Oxide and Hemodynamic Regulations -- Hemoglobin (Hb) -- Interactions Between NO and Hemoglobin -- Nitrosyl Hemoglobin -- NO Bioactivity and Hemoglobin -- NO, Red Cell Biology and Blood Substitutes -- NO Scavenging -- Conclusion -- References -- 10: A Brief History of the Development of Nanobiotechnology-Based Blood Substitutes -- Introduction -- Hemolysate and Stroma Free Hemoglobin -- Early Basic Research on Nanobiotechnology Based RBC Substitute -- Polyhemoglobin Based on Nanobiotechnology -- First Generation Hemoglobin Based Oxygen Carriers (HBOCs) -- Four General Types of HBOCs -- Development During the HIV Contaminated Donor Blood Crisis -- Intramolecularly Crosslinked Hemoglobin -- Polyhemoglobin -- Glutaraldehyde Crosslinked Human PolyHb -- Glutaraldehyde |
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Crosslinked Bovine PolyHb -- Conjugated Hemoglobin -- Nitric Oxide -- Inhalation of Nitric Oxide to Prevent Vasoconstriction -- Pyridoxalated Hemoglobin Polyoxyethylene as NO Scavenger in Distributive Shock -- Other Sources of Hemoglobin -- Bioengineering and Recombinant Methods -- Nanobiotechnology Based Oxygen Carriers with Antioxidant Functions -- Introduction -- PolyHb-CAT-SOD -- Convalently Binding of Nitroxides to PEG-Hb. |
Dual Carbon Monoxide and Oxygen Delivery Agent -- Vitamin C as Antioxidant -- Other Approaches -- Preservation for Transplant Organ -- Early Basic Research -- Light's Group -- Zal's Group -- Nanobiotechnology Based Oxygen Carriers with Enhancement of All Three RBC Functions -- Introduction -- Polyhemoglobin with Enhanced Catalase-Superoxide Dismutase-Carbonic Anhydrase -- Nanodimension Artificial Red Blood Cells -- Early Artificial Red Blood Cells -- Bilayer Lipid Membrane Nano Artificial RBC (Fig. 10.6) -- Nano-Dimension Biodegradable Polymeric Artificial Cells -- Variations in the Membrane and Configurations of Nano Artificial RBC -- Nonfunctional or Functional Membrane (Fig. 10.8) -- Other Areas -- Nanobiotechnology Based Oxygen Carrier with Platelet Function -- Nanobiotechnology Based Oxygen Carriers with Cancer Suppression Functions -- Stem Cells -- Future Development -- Summary Discussions -- What We Have Learned from Past History -- What Needs to Be Done -- References -- Part II: Pharmacology and Physiology of Oxygen Therapeutics -- 11: Classifications of Blood Substitutes -- Introduction -- Blood Composition -- Classification of Blood Substitutes -- Classification Based on the Blood Components -- Red Blood Cell Substitutes -- White Blood Cell (Leukocyte) Substitutes -- Platelet Substitutes -- Plasma Substitutes -- Classification of Erythrocyte Substitutes -- Hemoglobin-Based Oxygen Carriers -- Perfluorocarbon-Based Oxygen Carriers (PFBOC) -- Genetic Engineered Recombinant Hemoglobin -- Artificial and Cultured Red Blood Cells -- Erythrocyte Substitutes Classification Based on Hemoglobin Sources -- Erythrocyte Substitutes: Classification Based on RBC Membrane -- Erythrocyte Substitutes: Classification Based on Organic Molecule -- Erythrocyte Substitutes: Classification Based on Synthetic or Natural Molecule -- Ideal Erythrocyte Substitutes. |
Potential Indications for Blood Substitutes -- Summary -- References -- 12: Hemoglobin-Based Oxygen Carriers: Brief History, Pharmacology and Design Strategies, Review of the Major Products in Clinical Trials, On-Going Studies, and Coagulation Concerns -- Introduction -- Transfusion Medicine -- History of Hemoglobin-Based Oxygen Carriers -- How HBOCs Are Made -- Stroma Free Hemoglobin -- α-α Cross Linked Hb -- Glutaraldehyde Polymerized Hbs -- Recombinant HBOC -- Zero-Linked HBOCs -- Pegylated HBOCs -- Invertebrate Hb -- Pharmacology and Physiology of HBOCs -- Development of HBOCs -- Development of αα-Hb and HemAssist -- Development of Hemolink -- Development of Polyheme -- Development of Hemoximer -- Development of Hemopure and Summary/Discussion of Pivotal HEM-0115 Trial -- Adverse Events of Particular Interest -- Recent Clinical Trials on Hemopure -- Development of Third Generation HBOCs -- Coagulation and HBOCs -- Introduction -- Single Site Clinical Study of Hemopure on Platelet Function -- Summary of Hemopure -- Summary and Moving Forward -- References -- 13: Complications of HBOCs Including Clinical Safety Issues -- Introduction -- Criticism of the Natanson et al. Meta-Analysis -- Safety Aspects of Specific HBOCs -- HemAssist -- Optro -- Hemolink -- Polyheme -- MP40x-Hemospan ("3rd Generation") -- Hemopure (Biopure, OPK Pharma, HBO2 Therapeutics) -- Sanguinate (Prolong Pharmaceuticals) -- |
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Adverse Events -- Conclusion -- References -- 14: On the Oxidative Toxicity of Hemoglobin -- Red Blood Cell Oxidation Reactions in Health and Disease: What Have We Learned? -- Oxidation of Hemoglobin and Cytosolic Antioxidative Proteins -- The Role of Red Cell Band 3 in Hemoglobin Oxidation -- Hemoglobin-Driven Oxidation Reactions Promote Microparticles Formation -- Role of β Cysteine 93 in Oxidative Stability of Hemoglobin. |
Genetically and Chemically Modified HBOCs: The Impact of Molecular Modifications. |
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