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1. |
Record Nr. |
UNINA9910830217203321 |
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Autore |
Bornscheuer U. T (Uwe Theo), <1964-> |
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Titolo |
Hydrolases in organic synthesis [[electronic resource] ] : regio- and stereoselective biotransformations / / Uwe T. Bornscheuer and Romas J. Kazlauskas |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH |
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Chichester, : John Wiley, c2006 |
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ISBN |
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1-280-85420-0 |
9786610854202 |
3-527-60754-4 |
3-527-60712-9 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (369 p.) |
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Classificazione |
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Altri autori (Persone) |
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KazlauskasR. J <1956-> (Romas J.) |
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Disciplina |
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Soggetti |
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Catalysis |
Hydrolases |
Organic compounds - Synthesis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Hydrolases in Organic Synthesis; Preface for the 2(nd) edition; Preface for the 1(st) edition; Acknowledgments; Contents; 1 Introduction; 2 Designing Enantioselective Reactions; 2.1 Kinetic Resolutions; 2.1.1 Recycling and Sequential Kinetic Resolutions; 2.1.2 Dynamic Kinetic Resolutions; 2.1.2.1 Introduction; 2.1.2.2 Racemization by Protonation/Deprotonation; 2.1.2.3 Racemization by Addition/Elimination; 2.1.2.4 Racemization by Nucleophilic Substitution; 2.1.2.5 Racemization by Oxidation/Reduction; 2.1.2.6 Related Strategies; 2.2 Asymmetric Syntheses |
3 Choosing Reaction Media: Water and Organic Solvents3.1 Hydrolysis in Water; 3.2 Transesterifications and Condensations in Organic Solvents; 3.2.1 Increasing the Catalytic Activity in Organic Solvents; 3.2.1.1 Choosing the Best Organic Solvent for High Activity; 3.2.2 Increasing the Enantioselectivity in Organic Solvents; 3.2.3 Water Content and Water Activity; 3.3 Other Reaction Media; 3.3.1 Ionic Liquids; 3.3.2 Reverse Micelles; 3.3.3 Supercritical Fluids; 3.4 |
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Immobilization; 3.4.1 Introduction; 3.4.1.1 Increasing the Surface Area to Increase Catalytic Activity |
4 Protein Sources and Optimization of Biocatalyst Performance4.1 Accessing Biodiversity; 4.2 Creating Improved Biocatalysts; 4.2.1 Directed Evolution; 4.2.1.1 Methods to Create Mutant Libraries; 4.2.1.2 Assay Systems; 4.2.1.3 Selected Examples; 4.2.2 Focused Directed Evolution; 4.3 Catalytic Promiscuity in Hydrolases; 4.3.1 Reactions Involving Functional Group Analogs; 4.3.1.1 Perhydrolases; 4.3.2 Aldol and Michael additions Catalyzed by Hydrolases; 4.3.2.1 Aldol Additions; 4.3.2.2 Michael-Type Additions; 4.3.3 Modifications to Introduce New Reactivity in Hydrolases |
4.3.3.1 Enantioselective Reduction of Hydroperoxides with Selenosubtilisin4.3.3.2 Vanadate-Modified Phosphatases as Peroxidases; 5 Lipases and Esterases; 5.1 Availability, Structures and Properties; 5.1.1 Lipases; 5.1.1.1 Classification of Lipases; 5.1.1.2 General Features of PPL, PCL, CRL, CAL-B, and RML; 5.1.2 Esterases; 5.1.3 Lipases and Esterases are α/β Hydrolases; 5.1.4 Lid or Flap in Interfacial Activation of Lipases; 5.1.5 Substrate Binding Site in Lipases and Esterases; 5.1.6 Designing Reactions with Lipases and Esterases; 5.1.6.1 Acyl Donor for Acylation Reactions |
5.1.7 Assays for Lipases and Esterases5.1.7.1 Requirements for a Suitable Assay; 5.1.7.2 How to Distinguish Between Lipase, Esterase, and Protease; 5.2 Survey of Enantioselective Lipase-Catalyzed Reactions; 5.2.1 Alcohols; 5.2.1.1 Secondary Alcohols; 5.2.1.2 Primary Alcohols; 5.2.1.3 Other Alcohols, Amines, and Alcohol Analogs; 5.2.2 Carboxylic Acids; 5.2.2.1 General Considerations; 5.2.2.2 Carboxylic Acids with a Stereocenter at the α-Position; 5.2.2.3 Carboxylic Acids with a Stereocenter at the β-Position; 5.2.2.4 Other Carboxylic Acids; 5.2.2.5 Double Enantioselection; 5.2.2.6 Anhydrides |
5.2.3 Lactones |
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Sommario/riassunto |
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From reviews to the first edtion:""Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis."" (Nicholas J. Turner, University of Edinburgh)""The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapter |
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2. |
Record Nr. |
UNINA9910585992503321 |
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Autore |
Chávez Muriel Héctor Reynaldo |
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Titolo |
Subjetividad, lazo social y violencia: Conversación con Lizett Figueroa |
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Pubbl/distr/stampa |
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Colombia, : Universidad Santiago de Cali, 2018 |
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Descrizione fisica |
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1 online resource (75-108 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Hay diálogos que nos llevan a encuentros con efectos de lo real más allá de las diferencias culturales; las manifestaciones de la violencia, sus irrupciones como fracaso del pacto simbólico, son testimonio de ello. México y Colombia tienen en común muchas cosas, buena parte de ellas son maravillosas, sin embargo, también comparten el im-pacto de una violencia que no cesa, tanto por la presencia de grupos al margen de la ley, como por el tráfico de sustancias ilegales y la violencia agenciada directa e indirectamente por el Estado. Esta conversación nos permitió trasegar por esos efectos de lo real que nos interrogan desde fenómenos comunes que reclaman indagaciones particulares y comprensiones que den lugar a lo más singular del goce. La Dra. Figueroa ha investigado el tema en profundidad, específicamente en torno a la violencia que actualmente se manifiesta en el Estado de Veracruz, en México. Desde ese lugar, se hizo posible un rico y fructífero diálogo que nos permitió ir desde las problemáticas sociales hasta las formas más peculiares del goce y la satisfacción de la pulsión de muerte. Esperamos que el lector encuentre en esta discusión, variada en cuanto a las experiencias de quienes participamos, algunas ideas que provoquen rutas de reflexión en torno a las lógicas de la violencia que se tejen en las relaciones entre subjetividad y cultura. (John James Gómez) |
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