1.

Record Nr.

UNINA9910583347503321

Autore

Rezaei Nima

Titolo

Vaccines for cancer immunotherapy : an evidence-based review on current status and future perspectives / / Nima Rezaei, Mahsa Keshavarz-Fathi

Pubbl/distr/stampa

London, United Kingdom : , : Academic Press, an imprint of Elsevier, , [2019]

©2019

ISBN

0-12-814040-2

Descrizione fisica

1 online resource (185 pages)

Disciplina

616.994061

Soggetti

Cancer - Immunotherapy

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Front Cover -- Vaccines for Cancer Immunotherapy -- Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives -- Copyright -- Contents -- List of Contributors -- Preface -- 1 - CANCER IMMUNOLOGY -- INNATE AND ADOPTIVE IMMUNITY -- ACTIVATING IMMUNE CELLS -- MATURE DCS -- CLASSICALLY ACTIVATED MACROPHAGES (M1) -- GRANULOCYTES -- B LYMPHOCYTES -- T HELPER LYMPHOCYTES -- CYTOTOXIC T LYMPHOCYTES -- γδ T LYMPHOCYTES -- NATURAL KILLER T CELLS -- NATURAL KILLER CELLS -- INHIBITORY IMMUNE CELLS -- TOLEROGENIC DCS -- ALTERNATIVELY ACTIVATED MACROPHAGES (M2S) -- MYELOID-DERIVED SUPPRESSOR CELLS -- REGULATORY T CELLS -- REGULATORY B CELLS -- IMMUNOEDITING HYPOTHESIS -- ELIMINATION -- Cells -- Interferons -- Perforin -- Tumor Cell Recognition -- EQUILIBRIUM -- ESCAPE -- Defects in Tumor Antigen Processing, Presentation, and Recognition -- Lack of Activating Mechanisms -- Inhibitory Mechanisms and Immunosuppressive State -- Resistant Tumor Cells -- REFERENCES -- 2 - IMMUNOTHERAPEUTIC APPROACHES IN CANCER -- HISTORY -- APPROACHES OF CANCER IMMUNOTHERAPY -- PASSIVE VERSUS ACTIVE IMMUNOTHERAPY -- PASSIVE IMMUNOTHERAPY FOR CANCER -- Cytokines -- Monoclonal Antibodies (mAbs) -- Adoptive Cell Therapy -- ACTIVE IMMUNOTHERAPY FOR CANCER -- Vaccines --



Peptide Vaccine -- Tumor Cell Vaccine -- Dendritic Cell Vaccine -- Genetic Vaccine -- Checkpoint Inhibitors -- Oncolytic Viruses -- MECHANISM-BASED IMMUNOTHERAPIES: INTERACTIONS BETWEEN TUMOR CELLS AND THE IMMUNE SYSTEM -- TUMOR ANTIGEN EXPRESSION, RELEASE AND PRESENTATION -- T CELL PRIMING AND ACTIVATION -- TRAFFICKING AND INFILTRATION OF T CELLS TO TUMOR -- TUMOR CELL RECOGNITION AND EFFECTOR FUNCTION OF T CELLS -- REFERENCES -- 3 - VACCINES, ADJUVANTS, AND DELIVERY SYSTEMS -- DEFINITION AND CLASSIFICATION -- CANCER VACCINE -- PREVENTIVE CANCER VACCINE.

THERAPEUTIC CANCER VACCINE -- ADJUVANTS -- NONSPECIFIC ADJUVANTS -- CYTOKINES AND CHEMOKINES -- STIMULATORS OF THE INNATE IMMUNE SYSTEM -- C-type Lectin Receptor Ligands -- RIG-like Receptor Ligands -- Stimulator of Interferon Gene Ligands -- Toll like Receptor Ligands -- TLR2 Agonists -- TLR3 Agonists -- TLR4 Agonists -- TLR7 and TLR8 Agonists -- TLR9 Agonists -- Other Immunomodulatory Adjuvants -- Adjuvant Systems -- VECTORS AND DELIVERY SYSTEM -- ROUTE OF ADMINISTRATION -- REFERENCES -- 4 - TUMOR ANTIGENS -- INTRODUCTION -- IDENTIFICATION OF TUMOR ANTIGENS -- OVEREXPRESSED PROTEINS AND MUTATED ANTIGENS IN TUMOR CELLS -- EPITOPE SPREADING -- TUMOR-ASSOCIATED ANTIGENS -- TUMOR-SPECIFIC ANTIGENS -- NEOANTIGENS -- GLYCOLIPIDS AND GLYCOPROTEINS AS ANTIGENS -- MONO-EPITOPE VERSUS POLY-EPITOPE ANTIGEN -- REFERENCES -- 5 - STRATEGY OF ALLOGENEIC AND AUTOLOGOUS CANCER VACCINES -- AUTOLOGOUS CANCER VACCINES -- IN VIVO STUDIES AND CLINICAL IMPLICATIONS -- ALLOGENEIC CANCER VACCINES -- IN VITRO/IN VIVO STUDIES AND CLINICAL IMPLICATIONS -- REFERENCES -- 6 - PERSONALIZED CANCER VACCINE -- INTRODUCTION ON PERSONALIZED MEDICINE -- PERSONALIZED MEDICINE IN CANCER PATIENTS -- SCREENING OF CANCER -- CLASSIFICATION OF TUMORS -- TARGETED THERAPY AND USING PREDICTIVE BIOMARKERS -- SAFETY OF MEDICATION -- PROGNOSTIC BIOMARKERS -- NEOANTIGENS AND PERSONALIZED CANCER VACCINES -- PERSONALIZED CANCER VACCINES IN CLINICAL STUDIES -- WHOLE TUMOR CELL VACCINES -- PEPTIDE/PROTEIN-BASED VACCINE -- IMMUNE CELL-BASED VACCINES -- GENETIC-BASED VACCINE -- REFERENCES -- 7 - WHOLE TUMOR CELL VACCINE FOR CANCER -- TUMOR CELL LYSATES -- TUMOR-DERIVED EXOSOMES -- IRRADIATED GENE-MODIFIED TUMOR CELL VACCINE -- CLINICAL TRIALS -- APPROVED VACCINE -- ADVANTAGES AND DISADVANTAGES -- OPTIMIZATION -- REFERENCES -- 8 - PEPTIDE AND PROTEIN VACCINES FOR CANCER -- PEPTIDE-BASED VACCINE.

PROTEIN-BASED VACCINE -- MECHANISM OF ACTION -- CLINICAL TRIALS -- PEPTIDE-BASED VACCINE -- Gp100 -- BLP25 -- PROTEIN BASED VACCINE -- MAGE-A3 -- EGF-P64k -- ADVANTAGES AND DISADVANTAGES -- OPTIMIZATION -- REFERENCES -- 9 - IMMUNE CELL VACCINE FOR CANCER -- IMMUNE CELL VACCINE -- MECHANISM OF ACTION -- CLINICAL TRIALS -- IMMATURE DENDRITIC CELLS PULSED WITH TUMOR CELL LYSATES -- MATURE DENDRITIC CELLS PULSED WITH TUMOR CELL LYSATES -- DENDRITIC CELLS LOADED WITH TUMOR-DERIVED RNA -- DENDRITIC CELLS PULSED WITH PEPTIDES -- DENDRITIC CELLS LOADED WITH TUMOR CELLS -- APPROVED VACCINE -- ADVANTAGES AND DISADVANTAGES -- OPTIMIZATION -- REFERENCES -- 10 - GENETIC VACCINE FOR CANCER -- MECHANISM OF ACTION -- MECHANISM OF ACTION OF DNA VACCINES -- MECHANISM OF ACTION OF RNA VACCINES -- DNA VACCINE -- CLINICAL TRIALS -- DELIVERY, IMMUNOGENICITY AND IMMUNE RESPONSE -- ADVERSE EFFECTS -- RNA VACCINE -- CLINICAL TRIALS -- DELIVERY,



IMMUNOGENICITY AND IMMUNE RESPONSE -- ADVERSE EFFECTS -- ADVANTAGES AND DISADVANTAGES -- ADVANTAGES AND DISADVANTAGES OF DNA VACCINES -- ADVANTAGES OF RNA VACCINES -- OPTIMIZATION -- DNA VACCINE OPTIMIZATION -- RNA VACCINE OPTIMIZATION -- REFERENCES -- 11 - CANDIDATE CANCERS FOR VACCINATION -- VACCINES FOR PROSTATE CANCER -- VACCINES FOR MELANOMA -- VACCINES FOR LUNG CANCER -- VACCINES FOR COLORECTAL CANCER -- VACCINES FOR BREAST CANCER -- REFERENCES -- 12 - OBSTACLES IN THE DEVELOPMENT OF THERAPEUTIC CANCER VACCINES -- TUMOR ANTIGENS -- TUMOR BURDEN -- CLINICAL RESPONSE VERSUS IMMUNE RESPONSE -- PRIOR TREATMENTS -- DESIGNING CLINICAL TRIALS -- REFERENCES -- 13 - COMBINATION THERAPY: CANCER VACCINES AND OTHER THERAPEUTICS -- CHEMOTHERAPY COMBINED WITH VACCINES -- RADIATION COMBINED WITH VACCINES -- TARGETED THERAPIES COMBINED WITH IMMUNOTHERAPY -- HORMONE THERAPY COMBINED WITH VACCINE.

VACCINE COMBINED WITH OTHER IMMUNOTHERAPEUTIC MODALITIES -- REFERENCES -- 14 - CONCLUDING REMARKS AND FUTURE PERSPECTIVES ON THERAPEUTIC CANCER VACCINES -- CONCLUDING REMARKS -- BASIC IMMUNOLOGY OF CANCER VACCINES -- APPROVED VACCINES -- NEOANTIGEN VACCINES -- PREVENTIVE CANCER VACCINE -- CONSIDERATIONS TO FULFILL AMBITIONS -- REFERENCES -- Index -- Back Cover.



2.

Record Nr.

UNINA9910789710403321

Titolo

Africa Development Indicators 2011

Pubbl/distr/stampa

Washington, D.C. : , : The World Bank, , 2011

ISBN

1-283-37187-1

9786613371874

0-8213-8732-4

Descrizione fisica

1 online resource (184 pages)

Collana

Africa Development Indicators

Disciplina

330.96

330.96/0021

Soggetti

Corruption

Development

Exchange rates

Governance

Gross domestic product

Indicators

International trade

Macroeconomics and Economic Growth

National income

Price indexes

Purchasing power

Africa Politics and government

Africa Social life and customs

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

pt. 1. Basic indicators and national and fiscal accounts -- pt. 2. Millennium development goals -- pt. 3. Development outcomes.

Sommario/riassunto

Africa Development Indicators 2011 is the most detailed collection of data on Africa. It contains macroeconomic, sectoral, and social indicators for 53 countries. A companion CD-ROM has additional data, with some 1,700 indicators covering 1961-2009. Basic indicators; National and fiscal accounts; External accounts and exchange rates;



Millennium Development Goals; Private sector development; Trade and regional integration; Infrastructure; Human development; Agriculture, rural development, and the environment; Labor, migration, and population; HIV/AIDS and malaria; Capable states and partnership; Paris Declaration indicators; Governance and polity. Designed as both a quick reference and a reliable dataset for monitoring development programs and aid flows in the region, Africa Development Indicators 2011 is an invaluable tool for analysts and policymakers who want a better understanding of Africa's economic and social development.