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Record Nr. |
UNINA9910583324403321 |
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Titolo |
Approaches to the purifacation, analysis and characterization of antibody-based therapeutics / / edited by Allan Matte [and seven others] |
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Pubbl/distr/stampa |
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Amsterdam, Netherlands : , : Elsevier Limited, , [2020] |
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©2020 |
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ISBN |
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Descrizione fisica |
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1 online resource (224 pages) |
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Disciplina |
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Soggetti |
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Antibody-drug conjugates |
Immunoglobulins |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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1. Overview of therapeutic antibodies; 2. Platform purification approaches; 3. Strategies in the context of mAb downstream process development; 4. Process-scale purification of antibody therapeutics; 5. Process analytics for mAb purification and process development; 6. Automation approaches for small-scale mAb purification and assay development; 7. Glycan characterization of therapeutics mAbs; 8. Characterization of therapeutic antibodies using mass spectrometry; 9. Antibody binding studies using surface plasmon resonance and bio-layer interferometry methods; 10. Higher-order structure characterization methods; 11. Conformational and colloidal stability analysis of mAbs; 12. Future trends and opportunities. |
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Sommario/riassunto |
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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. |
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