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Record Nr. |
UNINA9910583324303321 |
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Autore |
Ignarro Louis J |
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Titolo |
Nitric Oxide : Biology and Pathobiology |
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Pubbl/distr/stampa |
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San Diego : , : Elsevier Science & Technology, , 2017 |
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©2017 |
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Edizione |
[3rd ed.] |
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Descrizione fisica |
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1 online resource (436 pages) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Nitric oxide - Physiological effect |
Nitric oxide - Pathophysiology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Cover -- Title Page -- Copyright Page -- Contents -- Contributors -- Introduction and Overview -- Chapter 1 - A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis -- Introduction -- NO and NOx Prior to 1986 -- Ancient Human/NOx, NO Relationships -- The Discovery of NO and 19th-Century Studies -- 20th-Century NO Prior to 1986 -- 1986-88: Convergence of the Discovery of Endogenous NO in the Immune, Cardiovascular, and Nervous Systems -- NO in the Immune System Prior to 1986-88 -- NO in the Cardiovascular System Prior to 1986-88 -- NO in the Nervous System Prior to 1986-88 -- The Convergence: 1986-88 -- Conclusions -- References -- Chapter 2 - An Integrated View of the Chemical Biology of NO, CO, H2S, and O2 -- Introduction -- Nitric Oxide -- Carbon Monoxide -- Hydrogen Sulfide -- Dioxygen -- Superoxide -- Hydrogen Peroxide -- Hydroxyl Radical -- Chemical Biology of NO, CO, H2S, and O2 Interactions -- Interactions at Metal Centers: Heme Proteins -- The Effect of O2 and Derived Species on the Chemical Biology of NO, CO, and H2S -- Interaction of NO and H2S -- Thiols/Thiol Proteins and NO, CO, O2, and H2S Chemical Biology -- Summary -- References -- Chapter 3 - Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review -- Detection of Nitric Oxide -- Introduction -- Detection of Nitrate and |
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Nitrite -- Griess Reaction -- Chemiluminescence Detection of Nitrite/Nitrate -- Other Methods for Nitrite/Nitrate -- Probes for NO Detection -- Nitronyl Nitroxides -- Iron Dithiocarbamates -- Diaminofluorescein (DAF) -- S-Nitrosothiol Detection -- Detection of Liberated Nitrogen Oxides From S-Nitrosothiols -- Saville Reaction -- Chemiluminescence -- Detection of Protein S-Nitrosothiols -- Biotin Switch Assay -- Other Methods -- Detection of Peroxynitrite Using Boronate-Based Probes. |
Introduction -- Oxidation of Boronates by Peroxynitrite and Other Biologically Relevant Oxidants -- Free Radical Pathway for the Reaction Between Boronates and ONOO− -- Real-Time Monitoring of ONOO− Formed In Situ in Cell-Free Systems -- Differentiation Between Different Oxidants Using Boronic Probes -- Detection of Peroxynitrite in Cellular Systems -- Perspectives for In Vivo Detection of Peroxynitrite -- Acknowledgment -- References -- Chapter 4 - S-Nitrosothiols and Nitric Oxide Biology -- Introduction -- RSNO Biochemistry: How Do RSNOs Relate to NO -- S-Nitrosothiol Levels and Targets In Vivo -- SNO Antibody -- RSNO Metabolism -- RSNO Formation -- Transnitrosation -- Denitrosation -- RSNO Transport -- Emerging Modulators of RSNO: Hydrogen Sulfide and Reactive Sulfur Species -- Biological Effects of RSNOs-Evidence and Interpretation -- RSNO Therapeutics -- RSNO as NO Donors -- Summary -- References -- Chapter 5 - Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology -- Chemical Aspects of the NO/H2S Cross-Talk -- Introduction -- Basic Chemical Properties of Sulfide as Compared to NO -- Bioactive Intermediates of the Reaction Between NO and Sulfide (and its Various Metabolites): S/N Hybrid Molecules and Poly... -- HSNO/ONS− -- ONSS− -- Polysulfides -- SULFI/NO -- Regulation of NOS Activity by H2S -- Regulation of PIP3/AKT/eNOS by Sulfide -- Regulation of eNOS Activity Via H2S-Mediated Sulfhydration -- Inhibitory Effect of H2S on NOS Activity -- Inhibitory Effect of NO on CBS Activity -- Regulation of NOS Expression by H2S -- Regulation of eNOS Expression by H2S -- Regulation of iNOS Expression by H2S -- Regulation of nNOS Expression by H2S -- Regulation of CBS, CSE, or 3-MST by NO -- Support of the NO/cGMP/PKG Signaling Axis by H2S -- H2S, a Redox Reactivator of Soluble Guanylate Cyclase. |
H2S, an "Endogenous Viagra": Inhibition of PDE Activity by H2S -- Direct Reaction of H2S With cGMP: Formation of 8-SH-cGMP -- Oxidative Activation of Protein Kinase G by Sulfide-Derived Polysulfides -- Support of NO Signaling Through H2S/ROS Interactions -- Implications -- Implications of the NO/H2S Cooperative Interactions for the Regulation of Vascular Tone, Vascular Growth, and Remodeling -- Potential Cooperative Actions of NO and H2S in the Central and Peripheral Nervous System -- Potential Cooperative Actions of NO and H2S in Cancer -- On the Interdependence of NO and H2S Signaling and Cytoprotection -- Outlook: Future Therapeutic Directions -- References -- Chapter 6 - Heme Protein Metabolism of NO and Nitrite -- Introduction -- NO Inactivation by Reaction With Heme Proteins -- NO Reactions With Ferrous Hemoglobins to Form Iron-Nitrosyl Complexes [Fe(II)-NO] -- Effects of Red Blood Cell Compartmentalization of Hemoglobin on NO Reaction Rates -- NO Generation by Reaction of Nitrite With Deoxygenated Heme Proteins -- Conclusions -- Acknowledgments -- References -- Chapter 7 - Cross-Regulation Between iNOS/NO and Wnt/β-Catenin Signaling Pathways -- List of Abbreviations -- Introduction -- NO-Induced Posttranslational Modification of Wnt/β-Catenin Signaling Proteins -- iNOS-Derived NO Promotes β-Catenin Phosphorylation -- iNOS-Derived NO Induces Nitration and S-Nitrosation of Proteins Related to Wnt/β-Catenin |
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Signaling Pathway -- iNOS/NO Induces Genetic Changes of Wnt/β-Catenin Pathway-Related Components -- Mutation of β-Catenin -- Loss of APC Heterozygosity -- iNOS/NO Regulates Wnt/β-Catenin Signaling -- iNOS/NO Targets Wnt/β-Catenin Signaling -- iNOS/NO Inversed DKK1 Expression Upregulated Wnt/β-Catenin Pathway -- iNOS/NO Regulates Both β-Catenin/TCF and NF-kB Transcriptional Functions -- iNOS Physically Interacts With β-Catenin. |
Wnt/β-Catenin Signaling Regulates iNOS/NO Pathway -- iNOS is a Targeted Gene of Wnt/β-Catenin Pathway -- Wnt/β-Catenin Regulated NF-kB Depending on the Induction of iNOS -- Conclusions -- References -- Chapter 8 - Regulation and Physiological Functions of NO-Sensitive Guanylyl Cyclase -- Introduction -- Isoforms and Molecular Properties of NO-Sensitive GC -- Activation of NO-GC by NO -- Novel Activators of NO-GC -- NO-GC Sensitizers and Heme-Mimetics in Clinical Testing -- NO-GC Inhibitors -- The NO/cGMP Signaling Cascade -- NO/cGMP-Induced Physiological Functions as Deduced From Genetic Deletion -- Blood Pressure Control -- Significance of NO-GC in Platelets -- Modulation of Synaptic Transmission -- LTP Is Lost in Both NO-GC KOs -- NO/cGMP in Glutamatergic Neurons -- NO/cGMP in GABAergic Neurons -- References -- Chapter 9 - Uncoupling of eNOS in Cardiovascular Disease -- Synthesis and Function of Endothelial NO -- The Phenomenon of eNOS Uncoupling -- Molecular Mechanisms of eNOS Uncoupling -- Uncoupling of eNOS in Cardiovascular Disease -- Hypertension -- Diabetes -- Atherosclerosis -- Pharmacological Prevention of eNOS Uncoupling -- Conclusions -- References -- Chapter 10 - Synthesis, Actions, and Perspectives of Nitric Oxide in Photosynthetic Organisms -- Nitric Oxide Synthesis in Photosynthetic Organisms -- Structure, Diversity, and Occurrence of Nitric Oxide Synthases (NOS) in Photosynthetic Organisms: Canonical NOS Is Absent i... -- Photosynthetic Organisms Do Not Synthetize the Biopterin Cofactor Required by NOS: The Role of Tetrahydrofolate -- Plants Possess Alternative Sources for NO Production -- Actions and Targets of NO in Photosynthetic Organisms -- NO as a Bioactive Signaling Molecule of Stress Responses in Land Plants -- Implications of NO in the Stress Responses of the Aquatic Photosynthetic Microorganisms. |
NO Is a Key Player in Auxin-Mediated Processes Leading to Root Growth and Development -- Targets and Molecular Mechanisms Underpinning NO Actions in Photosynthetic Organisms -- The Potential of NOS to Improve the Fitness of Crop Plants -- Concluding Remarks and Perspectives -- References -- Chapter 11 - Mitochondria and Nitric Oxide -- Introduction -- Sources of NO of Relevance to Mitochondria -- NO Inhibition of Cytochrome c Oxidase -- S-Nitrosation of Respiratory Complex i and Other Mitochondrial Proteins -- Mitochondrial Generation and Effects of Nitrated Fatty Acids -- Mitochondrial Generation and Effects of Peroxynitrite -- Cellular NO Signaling Regulation of Mitochondrial Dynamics and Number -- Summary and Integration of Concepts -- Acknowledgments -- References -- Chapter 12 - Nitric Oxide Formation From Inorganic Nitrate -- Introduction -- Sources of Nitrate and Nitrite -- The Enterosalivary Circulation of Nitrate -- Dietary Nitrate and Gastric Cancer -- Intragastric Generation of Nitric Oxide -- Interactions Between Nitrite and Other Dietary Compounds -- Systemic NO Generation From Nitrite -- Nitrite as a Vasodilator -- Mechanisms of Nitrite Reduction -- Dietary Nitrate and Cardiovascular Function -- Blood Pressure -- Pulmonary Hypertension -- Leukocyte and Platelet Activation -- Diabetes and Metabolic Syndrome -- How Is Inorganic Nitrate Bioactivated? -- Ergogenic Effects of Dietary Nitrate -- |
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Nutritional Aspects -- References -- Chapter 13 - Biochemistry of Molybdopterin Nitrate/Nitrite Reductases -- Introduction -- Microbial Nitrate Reductases -- Eukaryotic Nitrate and Nitrite Reductases -- Xanthine Oxidoreductase -- Nitrate/Nitrite and Reducing Substrates -- Microenvironmental pH -- O2 Concentration -- Immobilization of XO on the Endothelial Glycocalyx -- Isoform of XOR -- Aldehyde Oxidase -- Sulfite Oxidase. |
Mitochondrial Amidoxime Reducing Component. |
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