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Record Nr. |
UNINA9910583040403321 |
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Titolo |
The science of hormesis in health and longevity / / editors, Suresh I. S. Rattan, Marios Kyriazis |
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Pubbl/distr/stampa |
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London, United Kingdom : , : Academic Press, an imprint of Elsevier, , [2019] |
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©2019 |
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ISBN |
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Descrizione fisica |
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1 online resource (327 pages) |
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Disciplina |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Front Cover -- The Science of Hormesis in Health and Longevity -- Copyright Page -- Contents -- List of Contributors -- Preface -- I. History, Terminology and Challenges -- 1 The Dose-Response Revolution: How Hormesis Became Significant: An Historical and Personal Reflection -- 1.1 Introduction -- 1.2 My Introduction to Hormesis -- 1.3 Preparing for Hormesis -- 1.4 The First Hormesis Conference -- 1.5 The BELLE Initiative and Hormesis -- 1.6 The Funding of Hormesis Research -- 1.7 Hormesis: Gaining Acceptance Within the Scientific Community -- 1.8 The Critiques-From the Constructive to the Pathological -- 1.9 Other Leaders of Hormesis Research -- 1.10 Don Luckey and Radiation Hormesis -- 1.11 Hormesis: Gaining Acceptance -- 1.12 Spreading the Hormesis Word -- 1.13 The Enemy Within -- 1.14 Rewriting Toxicological and Risk Assessment History -- 1.15 The Michigan State-Transgenerational Hormesis Story -- 1.16 Hormesis and Awards -- 1.17 Hormesis Research and Leadership Accomplishments -- 1.17.1 Research Accomplishments -- 1.17.2 Leadership Accomplishments -- 1.18 Final Thoughts: The Road Less Taken -- Conflict of Interest -- Acknowledgment -- References -- 2 Mild Stress-Induced Hormesis: Hopes and Challenges -- 2.1 Why to Use Hormesis in Prevention and Therapy? -- 2.2 How to Use Hormesis in Prevention and Therapy? -- 2.2.1 What Mild Stresses to Use? -- 2.2.2 What Age for a Mild Stress? |
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-- 2.2.3 What Duration for a Mild Stress? -- 2.2.4 Individual Variability: Safety and Efficiency -- 2.3 Is It Possible to Mimic Hormesis? -- 2.4 Is It Useful to Combine Mild Stresses? -- 2.5 Hopes and Challenges for Therapy and Prevention -- 2.5.1 Using Mild Stress in Therapy -- 2.5.2 Using Mild Stress in Prevention -- 2.5.3 Qualifying Fasting as a Mild Stress for Therapy: An Ongoing Process -- 2.6 Conclusions -- References. |
3 Primary Stress Response Pathways for Preconditioning and Physiological Hormesis -- 3.1 Introduction -- 3.2 Heat Shock Response -- 3.2.1 HSF and Detection of Stress -- 3.2.2 HSP and Their Functional Role -- 3.2.3 HSR and Hormesis -- 3.3 Unfolded Protein Response -- 3.4 Oxidative Stress Response (OSR) -- 3.4.1 Regulation of Oxidative Stress -- 3.4.2 OSR and Hormesis -- 3.5 Hypoxia-Induced Stress Response (HISR) -- 3.6 DNA Damage Response -- 3.6.1 Detection and Repair of Double-Stranded DNA Breaks -- 3.7 Inflammatory Stress Response (ISR) -- 3.8 Energy Stress Response (ESR) -- 3.9 Nutritional Stress Response -- 3.10 Conclusions -- References -- II. Clinical and Lifestyle Hormesis -- 4 Remote Ischemic Conditioning as a Form of Hormesis -- 4.1 Introduction -- 4.2 Myocardial Infarct Size -- 4.3 Ischemic Preconditioning to Reduce Myocardial Infarct Size -- 4.4 Postconditioning to Reduce Myocardial Infarct Size -- 4.5 Remote Ischemic Conditioning to Reduce Myocardial Infarct Size -- 4.6 Other Applications of Remote Ischemic Conditioning -- 4.7 Conclusions -- References -- 5 Exercise and Hormesis -- 5.1 Introduction -- 5.2 Acute Adaptation to Exercise -- 5.3 The Effects of Regular Exercise on Housekeeping Pathways -- 5.4 Can Regular Exercise Attenuate the Aging Process? -- 5.4.1 Exercise and Neurodegenerative Diseases -- 5.4.2 Cardiovasular Diseases -- 5.4.3 Metabolic Diseases -- 5.4.4 Cancer -- 5.4.5 Sarcopenia -- 5.5 Conclusion -- References -- 6 Nutritional Hormesis in a Modern Environment -- 6.1 Introduction -- 6.2 Genetic Regulation of Aging -- 6.3 The Importance of Nutrition in Regulating the Aging Process -- 6.4 The Role of Good Nutrition for Health as We Age -- 6.5 The Diet, Hormesis, and Mitochondria -- 6.6 Oxidative Stress and Antioxidants -- 6.7 Dietary Sources of Hormetic Phytochemicals and Modulation of Age-Related Disease -- 6.7.1 Polyphenols. |
6.7.2 Carotenoids -- 6.7.3 Sulforaphane and Other Phytochemicals -- 6.8 Potential Mechanisms for Phytochemical Benefits in Aging -- 6.9 Bioavailability and Mechanisms of Cell uptake and Metabolism of Phytochemicals/Bioactive Compounds -- 6.10 Evidence for Molecular Damage Induced by Phytochemicals at Nontoxic Concentrations -- 6.11 Gaps and Opportunities -- References -- 7 Phyto-Hormetins in a Clinical Setting -- 7.1 Overview -- 7.2 Adaptive Nature of Hormesis: Phyto-Hormetins in the Animal and Human Diet -- 7.3 Hormesis Triggers and Biological CSRNs -- 7.4 Multitargeted Therapy and Nanoformulations of Phyto-Hormetins: Clinical Advantages and Implications for the Hormetic Do... -- 7.5 Summary and Conclusions -- References -- 8 Intermittent Fasting-Dietary Restriction as a Biological Hormetin for Health Benefits -- 8.1 Hormesis and Hormetins -- 8.2 Biological and Nutritional Hormetins -- 8.3 Dietary Restriction -- 8.4 Dietary Restriction as Hormetin -- 8.4.1 Beneficial Effects of Dietary Restriction -- 8.4.2 Dietary Restriction and Autophagy -- 8.4.3 Dietary Restriction and Neuroinflammation -- 8.5 Conclusion -- References -- 9 Hormetic Responses to Ethanol Ingestion: Focus on Moderation and Cardiovascular Protection -- 9.1 Introduction -- 9.2 Mechanisms of Cardiac Protection Induced by Ethanol Consumption -- 9.3 Protective Effects of Moderate Ethanol Ingestion in Stroke -- 9.4 Mitochondrial Aldehyde Dehydrogenase-2 Contributes to Ethanol-Induced Cardio- |
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and Neuroprotection in Ischemia/Reperfusion -- 9.5 Ethanol Postconditioning Reduces Ischemia/Reperfusion Injury -- 9.6 Adaptive Cytoprotection in Splanchnic Organs After Ethanol Exposure -- 9.7 Ethanol Induces the Development of an Antiinflammatory Phenotype That Limits Postischemic Tissue Injury -- 9.8 Summary and Conclusions -- Acknowledgments -- References. |
10 Thermal Waters and the Hormetic Effects of Hydrogen Sulfide on Inflammatory Arthritis and Wound Healing -- 10.1 Introduction -- 10.2 Hydrogen Sulfide and Inflammatory Arthritis -- 10.3 Hydrogen Sulfide and Wound Healing -- 10.4 Conclusions -- Acknowledgment -- References -- III. Hormetic Stressors -- 11 Hormesis Through Low-Dose Radiation -- 11.1 Introduction -- 11.2 Potential Mechanisms Underlying Hormetic Effects -- 11.2.1 Activation of DNA Repair Pathways -- 11.2.2 Activation of Endogenous Antioxidant Systems -- 11.2.3 Induction of the Heat Shock Response -- 11.2.4 Apoptosis, Autophagy, and Compensatory Cell Proliferation -- 11.2.5 Stimulating Immune Response -- 11.3 Conclusions and Perspectives -- References -- 12 Metabolic Stress-Signaling and Metabolic Adaptation -- 12.1 Introduction -- 12.2 Nutrients and Nutrient-Sensing Pathways -- 12.3 Metabolic Intermediates as Transducers of Adaptive Responses -- 12.4 Adaptive Responses to Metabolic Stress -- 12.4.1 Metabolic Reprogramming -- 12.4.2 Epigenetic Regulation of Gene Transcription -- 12.4.3 Autophagy -- 12.4.4 Increased Metabolic Activity and Reactive Oxygen Species Formation -- 12.5 Metabolic Stress and Aging -- 12.6 Metabolic Stress and Cancer -- 12.7 Conclusion -- Acknowledgment -- References -- 13 DNA-Damage-Induced Hormetic Responses -- 13.1 Introduction -- 13.2 Genotoxic Stressors and Their Impact on the Organism -- 13.3 DNA-Damage Response -- 13.4 DNA-Repair Mechanisms and Cellular Response -- 13.5 Epigenetic Alterations and DNA Damage -- 13.6 DNA-Damage-Mediated Regulation of Autophagy, Inflammasome, and Cytokine Signaling -- 13.7 Hormetic Effects of DNA-Damage Response Modify Inflammatory Response -- 13.8 Hormesis Lessons From Caenorhabditis elegans -- 13.9 Radon Therapy in Immune System and Disease -- 13.10 Conclusion -- Acknowledgment -- References. |
14 Pathogen-Induced Hormetic Responses -- 14.1 Innate Immune Memory as a New Paradigm -- 14.2 Trained Resistance and Tolerance Responses Are Specified by Pathogen Dose -- 14.3 Molecular Signatures of Trained Immunity and Tolerance Responses -- 14.4 Medical Relevance -- 14.5 Conclusions -- References -- 15 Neuronal Stress and Its Hormetic Aspects -- 15.1 Introduction -- 15.2 Long-Term Depression -- 15.3 Long-Term Potentiation -- 15.4 Excitotoxicity -- References -- 16 Energetic Stress and Proteodynamics in Aging and Longevity -- 16.1 Introduction -- 16.2 Proteostasis is Complex, Dynamic, and Inherently Difficult to Assess -- 16.3 Cell Proliferation Provides Critical Context for Interpreting Protein Turnover: A Key Proteodynamic Mechanism -- 16.4 Energetic Stress, Proteodynamics, and Longevity -- 16.5 Proteostasis is Intertwined with the Other Pillars of Aging -- 16.6 Concluding Remarks -- References -- 17 Repeated Electromagnetic Field Stimulation in Aging and Health -- 17.1 Introduction -- 17.2 Repetitive Electromagnetic Field Shock and Biological Systems Interaction -- 17.3 Sources and Nature of Fields and Exposure -- 17.4 REMFS Hormetic Effect in Aging and Age-Related Diseases -- 17.4.1 REMFS Delays Cellular Senescence -- 17.4.2 REMFS Lowers Amyloid Beta in Primary Human Brain Cell Cultures -- 17.4.3 REMFS Improves Cognition in Alzheimer's Disease Mouse Models by Lowering Amyloid Beta Deposits -- 17.4.4 REMFS Future Clinical Application -- 17.4.4.1 REMFS to Delay Aging Process -- 17.4.4.2 |
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REMFS to Treat Alzheimer's Disease and Other Protein Deposition Diseases -- 17.5 Conclusion -- References -- IV. Hormetic Interventions and Novel Perspectives -- 18 Hormesis for Healthy Aging -- 18.1 Introduction -- 18.2 Biological Basis of Aging -- 18.3 Hormetics and Hormetins -- 18.4 Thermal Hormesis -- 18.5 Exercise Hormesis -- 18.6 Radiation Hormesis. |
18.7 Calorie Restriction Hormesis. |
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