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Record Nr. |
UNINA9910583004803321 |
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Titolo |
Dubois' lupus erythematosus and related syndromes / / Daniel J. Wallace [and seven others], editors |
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Pubbl/distr/stampa |
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Edinburgh : , : Elsevier, , [2019] |
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©2019 |
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ISBN |
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Edizione |
[Ninth edition.] |
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Descrizione fisica |
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1 online resource (xv, 800 pages) : illustrations |
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Disciplina |
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Soggetti |
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Systemic lupus erythematosus |
Lupus erythematosus |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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History of lupus -- Definition and classification of lupus and lupus-related disorders -- The epidemiology of lupus -- Overview of lupus pathogenesis -- Genetics of human SLE -- Epigenetics of lupus -- The environment and the host -- The innate immune system in SLE -- B cells and generation of antibodies -- T cells -- Adaptive and innate immunoregulatory cells -- Cytokines in lupus -- Immunometabolism -- Animal models in lupus -- Abnormalities in immune complex clearance and apoptotic cell clearance -- The role of complement in SLE -- Apoptosis and inflammatory forms of cell death -- Tissue damage in lupus : free radicals and fibrosis -- Pathogenesis of fibrosis--the lung as a model -- Pathogenesis of lupus nephritis -- Pathogenesis of accelerated atherosclerosis and vascular injury in systemic lupus erythematosus -- Pathogenesis of cutaneous lupus -- Pathogenesis of neuropsychiatric lupus -- Pathogenesis of antiphospholipid antibody syndrome -- Pathogenesis of Sjögren's -- Structure and derivation of autoantibodies -- Antinuclear antibodies, antibodies to DNA, histones, and nucleosomes -- Antibodies against ENA (SM, RNP, SSA, SSB) -- Antibodies against C1q -- Antilipoprotein and antiendothelial cell antibodies -- Drug-induced lupus erythematosus -- Overview and clinical presentation -- Skin disease in cutaneous lupus erythematosus -- The musculoskeletal system and bone metabolism -- Lupus and the cardiopulmonary system -- Lupus |
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and the nervous system : clinical aspects, psychopathology, and imaging -- Gastrointestinal and hepatic systems -- Hematologic and lymphoid abnormalities in SLE -- Neonatal lupus : pathogenesis and clinical approaches -- Pregnancy and autoimmune disease, reproductive and hormonal issues -- Systemic lupus erythematosus in childhood and adolescence -- Clinical aspects of antiphospholipid syndrome -- Lupus and infections -- Ocular, aural, and oral manifestations of lupus -- Clinical aspects of Sjögren's -- Clinical application of serologic tests, serum protein abnormalities, and other clinical laboratory tests in systemic lupus erythematosus -- Differential diagnosis and disease associations -- Incomplete lupus, undifferentiated connective tissue disease, and mixed connective tissue disease -- Clinical markers, metrics, indices, and clinical trials -- Lupus biomarkers -- Principles of therapy, local measures, and NSAIDs -- Antimalarial medications -- Systemic glucocorticoid therapy for SLE -- Immunosuppressive drug therapy -- Complementary and alternative medications, specialized and niche therapies -- Adjunctive treatments and preventive measures -- Targeted therapies in SLE -- Management of cutaneous lupus erythematosus -- Epidemiology and management of lupus nephritis -- Management of Sjögren's -- Socioeconomic and disability aspects -- Prognosis and mortality of SLE. |
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Sommario/riassunto |
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"For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes"--Publisher's description. |
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