| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA990009825210403321 |
|
|
Autore |
Nicephorus Gregoras <1295-1359/1360> |
|
|
Titolo |
Nicephori Gregorae Byzantina historia Grece et Latine cum annotationibus Hier. Wolfii, Car. Ducangii, Io. Boivini et Cl. Capperonnerii. Cura Ludovici Schopeni Volumen I. [-II.] |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Bonnae, : impensis Ed. Weberi, 1829-1830 ( (Lipsiae) : ex officina B.G. Teubneri |
|
|
|
|
|
|
|
|
|
Titolo uniforme |
Byzantina historia <in greco e in latino> |
|
|
|
|
|
Edizione |
[Editio emendatior et copiosior, consilio B.G. Niebuhrii C.F. instituta, opera eiusdem Niebuhrii, Imm. Bekkeri, L. Schopeni, G. et L. Dindorfiorum aliorumque philologorum parata] |
|
|
|
|
|
|
|
Descrizione fisica |
|
|
|
|
|
|
Collana |
|
Corpus scriptorum historiae byzantinae ; 19 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Locazione |
|
|
|
|
|
|
Collocazione |
|
SG 880/B 91 (1) |
SG 880/B 91 (2) |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Paginazione e segnatura continue nei 2 v. |
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910438151403321 |
|
|
Autore |
Bartroff Jay |
|
|
Titolo |
Sequential Experimentation in Clinical Trials : Design and Analysis / / by Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
|
|
|
|
|
|
|
ISBN |
|
1-283-93454-X |
1-4614-6114-6 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed. 2013.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (249 p.) |
|
|
|
|
|
|
Collana |
|
Springer Series in Statistics, , 2197-568X ; ; 298 |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Biometry |
Statistics |
Biostatistics |
Statistical Theory and Methods |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Introduction -- Nonlinear Regression, Experimental Design, and Phase I Clinical Trials -- Sequential Testing Theory and Stochastic Optimization over Time -- Group Sequential Design of Phase II and III Trials -- Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health -- Time-Sequential Design of Clinical Trials with Failure-Time Endpoints -- Confidence Intervals and p-Values -- Adaptive Design of Confirmatory Trials -- References. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequential learning of unknown parameters is a central idea not only in adaptive designs of confirmatory clinical trials but also in the theory of optimal nonlinear experimental design, which the book covers as introductory material. Other introductory topics for which the book provides preparatory background include sequential testing theory, dynamic programming and stochastic optimization, |
|
|
|
|
|
|
|
|
|
|
survival analysis and resampling methods. In this way, the book gives a self-contained and thorough treatment of group sequential and adaptive designs, time-sequential trials with failure-time endpoints, and statistical inference at the conclusion of these trials. The book can be used for graduate courses insequential analysis, clinical trials, and biostatistics, and also for short courses on clinical trials at professional meetings. Each chapter ends with supplements for the reader to explore related concepts and methods, and problems which can be used for exercises in graduate courses. Jay Bartroff is Associate Professor of Mathematics at the University of Southern California where he is a member of the Laboratory of Applied Pharmacokinetics at the USC Keck School of Medicine. He is a leading expert on group sequential and multistage adaptive statistical procedures and their applications to clinical trial designs, and he is a sought-after consultant in academia and industry. Tze Leung Lai is Professor of Statistics, and by courtesy, of Health Research and Policy and of the Institute of Computational and Mathematical Engineering at Stanford University, where he is the Director of the Financial and Risk Modeling Institute and Co-director of the Biostatistics Core at the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine. He made seminal contributions to sequential analysis, innovative clinical trial designs, adaptive methods, survival analysis, nonlinear and generalized mixed models, hybrid resampling methods, and received the Committee of Presidents of Statistical Societies (COPSS) Award in 1983. Mei-Chiung Shih is Assistant Professor of Biostatistics and a member of the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine at Stanford University. She is also Associate Director for Scientific and Technical Operations at the Department of Veterans Affairs (VA) Cooperative Studies Program Coordinating Center at Palo Alto Health Care System. She is a leading expert on group sequential and adaptive designs and inference of clinical trials, longitudinal and survival data analysis, and has been leading the design, conduct and analysis of several large trials at the VA. |
|
|
|
|
|
|
|
|
|
|
|
|
|
3. |
Record Nr. |
UNINA9910580214803321 |
|
|
Autore |
Tanaka Masaru |
|
|
Titolo |
Crosstalk between Depression, Anxiety, and Dementia: Comorbidity in Behavioral Neurology and Neuropsychiatry |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (266 p.) |
|
|
|
|
|
|
Soggetti |
|
Clinical and internal medicine |
Medicine and Nursing |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
This Special Issue highlights the most recent research on depression, anxiety and dementia, with attention to comorbidity in a range of diseases. The symptoms of depression, anxiety and dementia are the most common comorbid manifestations present in patients suffering from neurodegenerative and psychiatric diseases. Together, these illnesses constitute an extremely complex and challenging research field due to their inherent multifactorial causative factors, heterogeneous pathogenesis, and mental and behavioral manifestations. This Special Issue covers laboratory, clinical and statistical studies on the crosstalk between depression, anxiety, dementia, Alzheimer's disease, multiple sclerosis, schizophrenia, diabetes mellitus, Down's syndrome, and/or compulsive disorders. It contains contributions from 71 authors, has been reviewed by 25 referees, and edited by three academic editors and one managing editor. |
|
|
|
|
|
|
|
| |