Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth

• Record Nr.: UNINA9910574099503321
• Pubbl/distr/stampa: Washington, DC, : ASM Press, c2011
• ISBN: 1-68367-093-0; 1-283-65649-3; 1-55581-721-1
• Descrizione fisica: 1 online resource (404 p.)
• Altri autori (Persone): HackerJörg (Jörg Hinrich); DobrindtUlrich; KurthReinhard <1942->
• Disciplina: 362.1969
• Soggetti: Communicable diseases - Genetic aspects; Microbial genomes; Pathogenic microorganisms - Genetics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Bacterial Infections; 1. Impact Of Genome Plasticity On Adaption Of; REDUCTIVE EVOLUTION OF E. COLI: ASYMPTOMATIC BACTERIURIA AS AN EXAMPLE OF BACTERIAL ADAPTATION TO PROLONGED IN VIVO GROWTH IN THE URINARY TRACT; IMPACT OF GENOMIC CHANGES ON BACTERIUM-HOST INTERACTION AND FITNESS; INTRAVESICLE GROWTH AFFECTS THE MOTILITY OF E. COLI; INTRAVESICLE GROWTH AFFECTS BACTERIAL GROWTH CHARACTERISTICS AND METABOLISM OF E. COLI; ANALYSIS OF HOST FACTORS AND THEIR IMPACT ON ADAPTATION OF E. COLI; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES 2. Genotypic Changes In Enterohemorrhagic Escherichia coli During Human Infection; EHEC: OVERVIEW OF EPIDEMIOLOGY AND CLINICAL PATHOGENESIS; GENOMES OF EHEC; IDENTIFICATION OF GENETIC CHANGES DURING EHEC INFECTIONS; INTERSEROTYPE DIFFERENCES IN CONVERSION OF EHEC TO EHEC-LST; CONSEQUENCES OF IN VIVO GENETIC CHANGES IN EHEC; DOES stx LOSS MITIGATE CLINICAL OUTCOME?; EVOLUTIONARY ASPECTS AND ADAPTATION; ; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCE; 3. Genomic Fluidity Of The Human Gastric Pathogen Helicobacter pylori; THE HELICOBACTER GENOMES; GENETIC MECHANISMS UNDERLYING GENOME DIVERSITY IN H. PYLORIGENOMIC ISLANDS OF H. PYLORI; FUNCTIONAL RELEVANCE OF THE PLASTIC GENOMES OF H. PYLORI; GENOMIC FLUIDITY OF H. PYLORI: CLINICAL IMPLICATIONS; PERSPECTIVES; REFERENCES; 4. Genome Structure And Variability in Coagulase-Negative Staphylococci; FITNESS AND VIRULENCE-ASSOCIATED FACTORS OF CoNS; THE oriC ENVIRON OF CoNS GENOMES: A HOT SPOT FOR GENOME REARRANGEMENTS; CoNS HAVE AN UNBALANCED GENOME STRUCTURE; CoNS GENOMES AND MOBILE GENETIC ELEMENTS; EXTENSIVE HORIZONTAL GENE TRANSFER AMONG CoNS AND MECHANISMS OF ITS LIMITATION; BIOFILM FORMATION ON MEDICAL DEVICES AND EVASION OF HOST DEFENSES BY CoNSPHENOTYPIC AND GENETIC INSTABILITY OF CoNS; CLINICAL IMPACT OF CoNS HETEROGENEOUS GENE EXPRESSION AND GENOME VARIABILITY; CONCLUSIONS; REFERENCES; 5. Genome Plasticity In Legionella pneumophila And Legionella longbeachae: Impact On Host Cell Exploitation; GENERAL FEATURES OF THE L. PNEUMOPHILA AND L. LONGBEACHAE GENOMES; HOST-PATHOGEN INTERACTION: SPECIFICITIES AND COMMON FEATURES OF L. PNEUMOPHILA AND L. LONGBEACHAE; EVOLUTION OF EUKARYOTIC EFFECTORS: ACQUISITION BY HORIZONTAL GENE TRANSFER; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES6. Genome Plasticity In Salmonella enterica And Its Relevance To Host-Pathogen Interactions; GENETIC MECHANISMS LEADING TO PLASTICITY AND HOST ADAPTATION IN SALMONELLA; GENOME ORGANIZATION IN SALMONELLA; SALMONELLA SEROVARS AND HOST ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7. Mechanisms Of Genome Plasticity In Neisseria meningitidis: Fighting Change With Change; GENETIC VARIABILITY AT THE POPULATION LEVEL; GENOME PLASTICITY IN THE PREGENOMIC ERA; THE SEQUENCED GENOMES OF N. MENINGITIDIS: AN OVERVIEW; GENERATION OF GENOME VARIABILITY IN N. MENINGITIDIS; GENETIC BASIS OF VIRULENCE IN N. MENINGITIDIS
• Sommario/riassunto: Comprehensive examination of the current understanding of pathogen adaptation and microevolution.