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1. |
Record Nr. |
UNINA9910257445703321 |
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Autore |
Chrusciel Piotr T |
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Titolo |
Hamiltonian Field Theory in the Radiating Regime / / by Piotr T. Chrusciel, Jacek Jezierski, Jerzy Kijowski |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2002 |
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ISBN |
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Edizione |
[1st ed. 2002.] |
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Descrizione fisica |
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1 online resource (VI, 174 p.) |
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Collana |
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Lecture Notes in Physics Monographs ; ; 70 |
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Disciplina |
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Soggetti |
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Gravitation |
Mathematical physics |
Classical and Quantum Gravity |
Mathematical Methods in Physics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Preliminaries -- Hamiltonian flows for geometric field theories -- Radiating scalar fields -- The energy of the gravitational field -- Hamiltonians associated with the BMS group. |
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Sommario/riassunto |
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The purpose of this monograph is to show that, in the radiation regime, there exists a Hamiltonian description of the dynamics of a massless scalar field, as well as of the dynamics of the gravitational field. The authors construct such a framework extending the previous work of Kijowski and Tulczyjew. They start by reviewing some elementary facts concerning Hamiltonian dynamical systems and then describe the geometric Hamiltonian framework, adequate for both the usual asymptotically-flat-at-spatial-infinity regime and for the radiation regime. The text then gives a detailed description of the application of the new formalism to the case of the massless scalar field. Finally, the formalism is applied to the case of Einstein gravity. The Hamiltonian role of the Trautman--Bondi mass is exhibited. A Hamiltonian definition of angular momentum at null infinity is derived and analysed. |
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2. |
Record Nr. |
UNINA9910557615903321 |
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Autore |
Aliño Salvador |
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Titolo |
Oligonucleotide, Therapy, and Applications |
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Pubbl/distr/stampa |
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Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
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Descrizione fisica |
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1 online resource (123 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs. |
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