Wound Repair and Regeneration : Mechanisms, Signaling

• Record Nr.: UNINA9910557501903321
• Autore: Akita Sadanori
• Pubbl/distr/stampa: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Descrizione fisica: 1 online resource (192 p.)
• Soggetti: Biology, life sciences; Research & information: general
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: Wound healing plays an integral part of cellular and molecular events. Sphingosine-1-phosphate (S1P) is a lipid mediator that promotes angiogenesis and cell proliferation and attracts immune cells. S1P plays a role in skin wound healing by altering the expression of its biogenic enzyme, sphingosine kinase-1 (SphK1). SphK1 overexpression also leads to less scarring through transforming growth factor (TGF)-β1 and S1P receptor-2 (S1PR2). IFN-γ might be involved in the proliferation and maturation stages of wound healing through the regulation of neutrophilic inflammatory responses in IFN--deficient (KO) mice. Topical recombinant human (rh)-growth hormone (GH) accelerated pressure ulcer (PU) healing in non-obese diabetic/severe combined immunodeficient mice engrafted with a full-thickness human skin graft model. Matrisome properties of scaffolds that direct fibroblasts in idiopathic pulmonary fibrosis and liver regeneration are enhanced by hepatocyte-derived angiogenesis via B-cell CLL/lymphoma/nuclear factor-kappa B signaling. Mechanisms of autologous adipose-derived stem cells in some patients with human immunodeficiency virus (HIV), treated by highly active antiretroviral therapy, are elucidated. The cloning and identification of thymosin (Pa-THYs) from Periplaneta americana, the American cockroach, suggest that this molecule could be a potential drug for promoting wound repair. Maresins (MaRs) and ; macrophages are reviewed, focusing on the potent action of MaRs in the enhancement of M2 macrophage phenotypic profiles to possibly alleviate inflammatory pain.