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1. |
Record Nr. |
UNINA9910346671303321 |
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Autore |
Zaffagnini Mirko |
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Titolo |
Thioredoxin and Glutaredoxin Systems / Mirko Zaffagnini, Jean-Pierre Jacquot |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (280 p.) |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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This Special Issue features recent data concerning thioredoxins and glutaredoxins from various biological systems, including bacteria, mammals, and plants. Four of the sixteen articles are review papers that deal with the regulation of development of the effect of hydrogen peroxide and the interactions between oxidants and reductants, the description of methionine sulfoxide reductases, detoxification enzymes that require thioredoxin or glutaredoxin, and the response of plants to cold stress, respectively. This is followed by eleven research articles that focus on a reductant of thioredoxin in bacteria, a thioredoxin reductase, and a variety of plant and bacterial thioredoxins, including the m, f, o, and h isoforms and their targets. Various parameters are studied, including genetic, structural, and physiological properties of these systems. The redox regulation of monodehydroascorbate reductase, aminolevulinic acid dehydratase, and cytosolic isocitrate dehydrogenase could have very important consequences in plant metabolism. Also, the properties of the mitochondrial o-type thioredoxins and their unexpected capacity to bind iron-sulfur center (ISC) structures open new developments concerning the redox mitochondrial function and possibly ISC assembly in mitochondria. The final paper discusses interesting biotechnological applications of |
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thioredoxin for breadmaking. |
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2. |
Record Nr. |
UNINA9910585943303321 |
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Autore |
Norek Małgorzata |
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Titolo |
Recent Advances in Metal, Ceramic, and Metal-Ceramic Composite Films/Coatings |
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Pubbl/distr/stampa |
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Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
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Descrizione fisica |
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1 online resource (156 p.) |
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Soggetti |
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Physics |
Research & information: general |
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This reprint gathers works on various coating materials and technologies aimed at the improvement of materials' properties, such as corrosion resistance or biocompatibility. Systematic studies demonstrate how the structure and morphology of coatings can change the mechanical, chemical and various functional properties of materials. The reprint contributes to the better understanding of various phenomena induced by metal, ceramic or composite coatings in core materials and, thus, it can help in the more rational design of the selected material's properties in future studies by the application of coatings. |
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3. |
Record Nr. |
UNINA9910557498903321 |
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Autore |
Lamberti Gaetano |
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Titolo |
Drug Delivery of siRNA Therapeutics |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (288 p.) |
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Lingua di pubblicazione |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs. |
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