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1. |
Record Nr. |
UNINA9910557298403321 |
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Autore |
Hariri-Ardebili M. Amin |
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Titolo |
Advances in Dam Engineering |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (202 p.) |
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Soggetti |
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History of engineering and technology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Expansion of water resources is a key factor in the socio-economic development of all countries. Dams play a critical role in water storage, especially for areas with unequal rainfall and limited water availability. While the safety of existing dams, periodic re-evaluations and life extensions are the primary objectives in developed countries, the design and construction of new dams are the main concerns in developing countries. The role of dam engineers has greatly changed over recent decades. Thanks to new technologies, the surveillance, monitoring, design and analysis tasks involved in this process have significantly improved. The current edited book is a collection of dam-related papers. The overall aim of this edited book is to improve modeling, simulation and field measurements for different dam types (i.e. concrete gravity dams, concrete arch dams, and embankments). The articles cover a wide range of topics on the subject of dams, and reflect the scientific efforts and engineering approaches in this challenging and exciting research field. |
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2. |
Record Nr. |
UNINA9910557221703321 |
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Autore |
Boué-Grabot Eric |
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Titolo |
Purinergic Signaling in Health and Disease |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (330 p.) |
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Soggetti |
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Neurosciences |
Science: general issues |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Adenosine 5'-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy "currency." After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including |
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depression, anxiety and schizophrenia. |
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