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Record Nr. |
UNINA9910557286503321 |
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Autore |
Müller Rüdiger |
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Titolo |
Rheumatoid Arthritis Therapy Reappraisal : Strategies, Opportunities and Challenges |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (260 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Rheumatoid Arthritis (RA) is a chronic inflammatory disease leading to joint inflammation and destruction. Treatment of RA includes the use of conventional (cs), biologic (b) disease-modifying anti-rheumatic drugs (DMARDs), and oral or intraarticular (IA) glucocorticoids (GCs). All different classes of drugs have shown to halt disease progression in clinical studies. In real life, a physician has more options than just adding or switching to a new ts/bDMARD if any kind of DMARDs has failed. They can modify or optimize the therapy with concomitant csDMARDs, and oral or IA-GC can be added to the treatment regimen. The EULAR states that therapeutic adjustment including the "optimization of csDMARDs dose or route of administration or intra-articular injections of GCs" is recommended. Thus, a new therapeutic agent can be embedded in a whole strategy with parallel optimization of the csDMARD and GC treatment. The idea of treating to target (T2T) for the treatment of RA patients has been around since the late 1990s. Many clinical studies (Ticora, BsSt, Camera) have demonstrated the superiority of a T2T approach. When I talk to physicians, I understand that most of them only rarely inject joints with GC. Therefore, I would like to create an issue on the T2T approach in reality including primary data, reviews, and real-life data demonstrating the general opinion and execution of T2T in treating RA. |
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2. |
Record Nr. |
UNINA9911019205403321 |
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Autore |
Baker Gordon P |
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Titolo |
Wittgenstein [[electronic resource] ] : understanding and meaning . Part 1 Essays / / G.P. Baker & P.M.S. Hacker |
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Pubbl/distr/stampa |
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Malden, MA ; ; Oxford, : Blackwell Pub., 2005 |
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ISBN |
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1-281-32273-3 |
9786611322731 |
0-470-75280-7 |
0-470-75279-3 |
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Edizione |
[2nd., extensively rev. ed. /] |
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Descrizione fisica |
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1 online resource (420 p.) |
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Collana |
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Analytical commentary on the Philosophical investigations ; ; v. 1 |
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Altri autori (Persone) |
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HackerP. M. S (Peter Michael Stephan) |
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Disciplina |
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Soggetti |
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Philosophy |
Language and languages - Philosophy |
Semantics (Philosophy) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Wittgenstein: Understanding and Meaning; Contents; Acknowledgements; Introduction to Part I: Essays; Abbreviations; I The Augustinian conception of language (1); 1. Augustine's picture; 2. The Augustinian family; (a) word-meaning; (b) correlating words with meanings; (c) ostensive explanation; (d) metapsychological corollaries; (e) sentence-meaning; 3. Moving off in new directions; 4. Frege; 5. Russell; 6. The Tractatus; II Explanation (6); 1.Training, teaching and explaining; 2. Explanation and meaning; 3. Explanation and grammar; 4. Explanation and understanding |
III The language-game method (7)1. The emergence of the game analogy; 2. An intermediate phase: comparisons with invented calculi; 3. The emergence of the language-game method; 4. Invented language-games; 5. Natural language-games; IV Descriptions and the uses of sentences (18); 1. Flying in the face of the facts; 2. Sentences as descriptions of facts: surface-grammatical paraphrase; 3. Sentences as descriptions: depth-grammatical analysis and descriptive contents; 4. Sentences as instruments; 5. Assertions, questions, commands make contact in language |
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V Ostensive definition and its ramifications (28)1. Connecting language and reality; 2. The range and limits of ostensive explanations; 3. The normativity of ostensive definition; 4. Samples; 5. Misunderstandings resolved; 6. Samples and simples; VI Indexicals (39); VII Logically proper names (39); 1. Russell; 2. The Tractatus; 3. The criticisms of the Investigations: assailing the motivation; 4. The criticisms of the Investigations: real proper names and simple names; VIII Meaning and use (43); 1. The concept of meaning; 2. Setting the stage |
3. Wittgenstein: meaning and its internal relations4. Qualifications; IX Contextual dicta and contextual principles (50); 1. The problems of a principle; 2. Frege; 3. The Tractatus; 4. After the Tractatus; 5. Compositional theories of meaning; 6. Computational theories of understanding; X The standard metre (50); 1. The rudiments of measurement; 2. The standard metre and canonical samples; 3. Fixing the reference or explaining the meaning?; 4. Defusing paradoxes; XI Family resemblance (65); 1. Background: definition, logical constituents and analysis |
2. Family resemblance: precursors and anticipations3. Family resemblance: a minimalist interpretation; 4. Sapping the defences of orthodoxy; 5. Problems about family-resemblance concepts; 6. Psychological concepts; 7. Formal concepts; XII Proper names (79); 1. Stage-setting; 2. Frege and Russell: simple abbreviation theories; 3. Cluster theories of proper names; 4. Some general principles; 5. Some critical consequences; 6. The significance of proper names; 7. Proper names and meaning; XIII Turning the examination around: the recantation of a metaphysician (89) |
1. Reorienting the investigation |
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Sommario/riassunto |
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This is a new edition of the first volume of G.P.Baker and P.M.S. Hacker's definitive reference work on Wittgenstein's Philosophical Investigations. New edition of the first volume of the monumental four-volume Analytical Commentary on the Philosophical Investigations. Takes into account much material that was unavailable when the first edition was written. Following Baker's death in 2002, P.M.S. Hacker has thoroughly revised the first volume, rewriting many essays and sections of exegesis completely. Part One - the Essays - now includes tw |
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