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Record Nr. |
UNINA9910463146103321 |
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Autore |
Twisk Jos W. R. <1962-> |
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Titolo |
Applied longitudinal data analysis for epidemiology : a practical guide / / Jos W.R. Twisk, Department of Epidemiology and Biostatistics, Medical Center and the Department of Health Sciences of the Vrije Universteit, Amsterdam [[electronic resource]] |
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Pubbl/distr/stampa |
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Cambridge : , : Cambridge University Press, , 2013 |
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ISBN |
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1-107-06535-6 |
1-316-09031-0 |
1-107-05691-8 |
1-107-05475-3 |
1-107-05804-X |
1-107-05931-3 |
1-139-34283-5 |
1-107-05581-4 |
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Edizione |
[Second edition.] |
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Descrizione fisica |
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1 online resource (xiv, 321 pages) : digital, PDF file(s) |
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Collana |
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Cambridge medicine Applied longitudinal data analysis for epidemiology |
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Disciplina |
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Soggetti |
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Epidemiology - Research - Statistical methods |
Epidemiology |
Epidemiology - Statistical methods |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from publisher's bibliographic system (viewed on 05 Oct 2015). |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Machine generated contents note: Preface; Acknowledgements; 1. Introduction; 2. Study design; 3. Continuous outcome variables; 4. Continuous outcome variables - relationships with other variables; 5. The modelling of time; 6. Other possibilities for modelling longitudinal data; 7. Dichotomous outcome variables; 8. Categorical and 'count' outcome variables; 9. Analysis data from experimental studies; 10. Missing data in longitudinal studies; 11. Sample size calculations; 12. Software for longitudinal data analysis; 13. One step further; References; Index. |
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Sommario/riassunto |
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This book discusses the most important techniques available for |
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longitudinal data analysis, from simple techniques such as the paired t-test and summary statistics, to more sophisticated ones such as generalized estimating of equations and mixed model analysis. A distinction is made between longitudinal analysis with continuous, dichotomous and categorical outcome variables. The emphasis of the discussion lies in the interpretation and comparison of the results of the different techniques. The second edition includes new chapters on the role of the time variable and presents new features of longitudinal data analysis. Explanations have been clarified where necessary and several chapters have been completely rewritten. The analysis of data from experimental studies and the problem of missing data in longitudinal studies are discussed. Finally, an extensive overview and comparison of different software packages is provided. This practical guide is essential for non-statisticians and researchers working with longitudinal data from epidemiological and clinical studies. |
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2. |
Record Nr. |
UNINA9910557134503321 |
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Autore |
Benini Stefano |
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Titolo |
Carbohydrate-Active Enzymes : Structure, Activity and Reaction Products |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (408 p.) |
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Soggetti |
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Biology, life sciences |
Research & information: general |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Carbohydrate-active enzymes are responsible for both biosynthesis and the breakdown of carbohydrates and glycoconjugates. They are involved in many metabolic pathways; in the biosynthesis and degradation of various biomolecules, such as bacterial |
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exopolysaccharides, starch, cellulose and lignin; and in the glycosylation of proteins and lipids. Carbohydrate-active enzymes are classified into glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterases, and enzymes with auxiliary activities (CAZy database, www.cazy.org). Glycosyltransferases synthesize a huge variety of complex carbohydrates with different degrees of polymerization, moieties and branching. On the other hand, complex carbohydrate breakdown is carried out by glycoside hydrolases, polysaccharide lyases and carbohydrate esterases. Their interesting reactions have attracted the attention of researchers across scientific fields, ranging from basic research to biotechnology. Interest in carbohydrate-active enzymes is due not only to their ability to build and degrade biopolymers-which is highly relevant in biotechnology-but also because they are involved in bacterial biofilm formation, and in glycosylation of proteins and lipids, with important health implications. This book gathers new research results and reviews to broaden our understanding of carbohydrate-active enzymes, their mutants and their reaction products at the molecular level. |
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