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Record Nr. |
UNINA9910619467203321 |
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Autore |
Sousa Flávia |
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Titolo |
Brain-Targeted Drug Delivery |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
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ISBN |
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Descrizione fisica |
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1 online resource (260 p.) |
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Soggetti |
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Technology: general issues |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer's and Parkinson's diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presence of the blood-brain barrier (BBB), which covers the entirety of the brain. The BBB not only has the function of protecting the brain from harmful substances; it is also a metabolic barrier and a transport regulator of nutrients/serum factors/neurotoxins. Knowing these characteristics when it comes to the treatment of brain diseases makes it easier to understand the lack of efficacy of therapeutic drugs, resulting from the innate resistance of the BBB to permeation. To overcome this limitation, drug delivery systems based on nanotechnology/microtechnology have been developed. Brain-targeted drug delivery enables targeted therapy with a higher therapeutic efficacy and fewer side effects because it targets moieties present in the drug delivery systems. |
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2. |
Record Nr. |
UNINA9910557129903321 |
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Autore |
Mesías Marta |
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Titolo |
New Frontiers in Acrylamide Study in Foods : Formation, Analysis and Exposure Assessment |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
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Descrizione fisica |
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1 online resource (156 p.) |
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Soggetti |
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Biology, life sciences |
Food & society |
Research & information: general |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The European Food Safety Agency (EFSA) has identified acrylamide as a public health concern due to its relation with the appearance of different types of cancer, and continued efforts are required to reduce exposure to acrylamide (EFSA, 2015). During the last few years, EFSA has maintained a high level of supervision to monitor the acrylamide levels in processed products, urging companies to implement effective mitigation strategies for reducing formation of this contaminant. Recently, the European Commission has published a regulation that sets mitigation measures for the reduction of this compound in foods, identifying new benchmark levels for a number of food categories (European Commission, 2017). The Regulation 2158/2017 compels food processors and food business operators in Europe to reduce the presence of acrylamide in their products, applying measures proportionate to the size and nature of the establishments. With the goal of providing information that contributes to our understanding for this process contaminant and exposure through dietary routes, this Special Issue explores the recent advances on the study of acrylamide in foods, including novel insights into the chemistry of its formation and elimination, effective mitigation strategies, conventional and innovative monitoring techniques, risk/benefit approaches, and |
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