1.

Record Nr.

UNINA9910523748403321

Titolo

Sport-related sudden cardiac death : causes and prevention / / edited by Pietro Delise and Paolo Zeppilli

Pubbl/distr/stampa

Cham, Switzerland : , : Springer, , [2022]

©2022

ISBN

3-030-80447-X

Descrizione fisica

1 online resource (196 pages)

Disciplina

616.12075

Soggetti

Heart - Diseases - Diagnosis

Sudden death

Heart failure

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

Intro -- Preface -- Contents -- 1: Sudden Death in Athletes: Autoptic Findings -- 1.1  Introduction -- 1.2  Aorta and Pulmonary Artery -- 1.3  Coronary Arteries -- 1.4  Myocardium -- 1.5  Valve Disease -- 1.6  Conduction System -- 1.7  Ion Channel Diseases: Sudden Death with Structurally Normal Heart -- 1.8  Role of Autopsy in Case of Sudden Death in Athletes -- 1.9  Toxicological Analysis -- 1.9.1  Sample Preparation -- 1.9.2  General Unknown Screening -- 1.9.3  Interpretation of Results -- References -- 2: Electrocardiographic Changes in the Athlete's Heart -- 2.1  Introduction -- 2.2  The Athlete's ECG: General Considerations -- 2.3  Physiological Changes -- 2.4  Borderline Changes -- 2.5  Abnormal or Pathological Changes -- References -- 3: Benign Arrhythmias and Conduction Defects in Athletes -- 3.1  Sinus Arrhythmia -- 3.1.1  Definition -- 3.1.2  Epidemiology in Sport -- 3.1.3  Current Guidelines -- 3.2  Sinus Bradycardia -- 3.2.1  Definition -- 3.2.2  Epidemiology in Sport -- 3.2.3  Current Guidelines -- 3.3  Right Bundle Branch Block -- 3.3.1  Definition -- 3.3.2  Epidemiology in Sport -- 3.3.3  Current Guidelines -- 3.4  Left Bundle Branch Block -- 3.4.1  Definition -- 3.4.2  Epidemiology in Sport -- 3.4.3  Current Guidelines -- 3.5  Atrio-Ventricular Blocks -- 3.5.1  Definition -- 3.5.2  Epidemiology in Sport -- 3.5.3  Current Guidelines -- 3.6  Premature Ventricular Beats --



3.6.1  Definition -- 3.6.2  Epidemiology in Athletes -- 3.6.3  Current Guidelines -- References -- 4: Hypertrophic Cardiomyopathy and Left Ventricular Non-Compaction -- 4.1  Text -- 4.2  Risk Stratification in Athletes with Hypertrophic Cardiomyopathy -- 4.3  Left Ventricular Non-Compaction Cardiomyopathy -- References -- 5: Arrhythmogenic Cardiomyopathy -- 5.1  Introduction -- 5.2  Definition and Pathological Findings.

5.3  Pathophysiology of Ventricular Arrhythmias in AC -- 5.4  AC and SD in Athletes -- 5.5  Early Identification at Pre-participation Screening -- References -- 6: Acute and Chronic Myocarditis -- 6.1  Clinical and Electrocardiographic Findings -- 6.2  Additional Instrumental Findings (Imaging Techniques and Endomyocardial Biopsy) -- 6.3  Athletes with Fever: What to Suggest to Sports Physicians -- 6.4  Long-Term Outcome of Myocarditis: Chronic Persistence of Inflammation and Residual Fibrosis -- 6.5  Clinical and Prognostic Significance of Chronically Residual Fibrosis -- 6.6  When ECG Suggests the Presence of Fibrosis -- 6.7  Sport Eligibility After Myocarditis -- References -- 7: Congenital and Acquired Anomalies of Coronary Arteries -- 7.1  Introduction -- 7.2  Congenital Anomalies -- 7.3  Anomalous Origin of Coronary Arteries -- 7.4  Myocardial Bridge -- 7.5  Coronary Fistulae -- 7.6  Acquired Anomalies -- 7.6.1  Coronary Atherosclerosis -- 7.6.2  Kawasaki's Disease -- 7.6.3  Cocaine-Induced Coronary Disease -- References -- 8: Interpretation and Diagnostic Workup of Premature Ventricular Beats -- 8.1  Introduction -- 8.2  The Concept of "Common" and "Uncommon" PVBs -- 8.3  Pathological Substrates in Athletes with PVBs -- 8.4  Recent Evidence on Ventricular Ectopy in Athletes -- 8.5  Diagnostic Workup of Premature Ventricular Beats in Athletes -- 8.6  Conclusions -- References -- 9: Fear of Sudden Death During Sport Activity and the Long QT Syndrome -- 9.1  Foreword -- 9.2  Introduction -- 9.3  Key Features of LQTS -- 9.4  Problems and Errors -- 9.5  What Should Not Happen -- 9.6  A Dangerous Trap -- 9.7  Our Approach and Our Recommendations -- References -- 10: Short QT Syndrome -- 10.1  Background -- 10.2  ECG Diagnosis of Short QT Syndrome and Differential Diagnosis -- 10.2.1  QT and QTc Interval -- 10.2.2  QT/HR Relationship.

10.2.3  Other ECG Features -- 10.2.3.1  T Wave Morphology and J-Tpeak Interval -- 10.2.3.2  PQ Segment Depression -- 10.2.3.3  Early Repolarisation Pattern -- 10.3  Genetics and Molecular Basis -- 10.4  Clinical Manifestations and Mechanisms of Arrhythmias -- 10.5  Management of SQTS Patients -- 10.6  Sports Recommendations -- References -- 11: Brugada ECG Pattern and Brugada Syndrome -- 11.1  Brugada Type 1 ECG and Prognosis -- 11.2  Genetic Basis of Brugada Syndrome -- 11.3  Risk Stratification in Individuals with Brugada Type 1 ECG Pattern -- 11.4  Brugada ECG Pattern in Athletes -- 11.5  Brugada Syndrome and Risk of SD Related to Sport Activity -- 11.6  Sports Eligibility in Subjects with Brugada Syndrome and a BrS Type 1 ECG -- 11.7  Drug-Induced Br Type 1 ECG: Indications and Sports Eligibility -- References -- 12: Early Repolarization Syndrome -- 12.1  Benign Left ER and ERS Differential Diagnosis -- 12.2  Early Repolarization Syndrome Causes and Complications -- 12.3  ERS ECG Pattern and Risk of SD Related to Sport Activity -- 12.3.1  Sports Eligibility in Subjects with Definite or Suspected ERS -- References -- 13: Catecholaminergic Polymorphic Ventricular Tachycardia -- 13.1  Introduction -- 13.2  Epidemiology -- 13.3  Genetic Background -- 13.3.1  Cardiac Ryanodine Receptor (RYR2) -- 13.3.2  Cardiac Calsequestrin (CASQ2) -- 13.4  Other Genes Associated with CPVT -- 13.4.1  Triadin (TRDN) -- 13.4.2  Calmodulin (CALM) -- 13.4.3  Trans-2,3-Enoyl-CoA Reductase-Like (TECRL) -- 13.5  Pathophysiology -- 13.5.1  



Excitation-Contraction Coupling and Calcium-Induced Calcium Release (CICR) -- 13.6  Molecular Pathophysiology -- 13.6.1  RYR2 Mutations -- 13.6.2  CASQ2 Mutations -- 13.6.3  TRDN Mutations -- 13.7  Arrhythmogenic Mechanisms -- 13.8  Clinical Manifestations and Diagnosis -- 13.9  Differential Diagnosis -- 13.10  Principles of Management.

13.11  Lifestyle -- 13.12  Pharmacological Treatment -- 13.12.1  Beta-Blockers -- 13.12.2  Flecainide -- 13.13  Left Cardiac Sympathetic Denervation -- 13.14  Implantable Cardioverter Defibrillator -- 13.15  Future Therapies -- References -- 14: Sport Activity in Subjects with Implantable Defibrillator -- 14.1  Background -- 14.2  Epidemiology -- 14.3  Cultural Aspects and Published Experiences -- 14.4  Actual Recommendations (Tables 14.1, 14.2, and 14.3) -- 14.5  Subcutaneous ICD -- 14.6  Discussion and Perspectives -- References.