Applications of nanomaterials in proteomics / / Nianrong Sun, Chunhui Deng, Xizhong Shen

• Record Nr.: UNINA9910502658203321
• Autore: Sun Nianrong
• Pubbl/distr/stampa: Singapore : , : Springer, , [2021]; ©2021
• ISBN: 981-16-5816-1
• Descrizione fisica: 1 online resource (431 pages)
• Collana: Nanostructure Science and Technology
• Disciplina: 620.115
• Soggetti: Nanostructured materials; Proteomics; Nanostructures
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Intro -- Preface -- Contents -- 1 An Overview of Proteomics and Related Nanomaterials -- 1.1 Introduction of Proteomics -- 1.1.1 Concept Introduction -- 1.1.2 Research Strategy in Proteomics -- 1.2 Introduction of PTM Proteomics -- 1.2.1 Concept Introduction -- 1.2.2 Common PTMs -- 1.2.3 Cross-Link of Glycosylation and Phosphorylation -- 1.2.4 Research Methods in PTM Proteomics -- 1.3 Introduction of Peptidomics -- 1.4 Nanomaterials as Separation Media -- 1.4.1 Nanomaterials in Ordinary Proteomics -- 1.4.2 Nanomaterials in Phosphorylated Proteomics -- 1.4.3 Nanomaterials in Glycosylated Proteomics -- 1.4.4 Nanomaterials in Peptidomics -- References -- 2 Application of Nanomaterials to Separation of Low-Abundance Proteins -- 2.1 Introduction -- 2.2 Hydrophobic-Hydrophobic Interaction -- 2.2.1 Graphene as Functional Group -- 2.2.2 Other Carbon as Functional Group -- 2.2.3 Alkyl Chain as Functional Group -- 2.2.4 Polymer as Functional Group -- 2.3 Metal Ion/Oxide as Functional Group -- 2.3.1 Metal Oxide -- 2.3.2 Metal Ion -- 2.4 Hydrazide as Functional Group -- 2.5 Specific Peptide as Functional Group -- 2.6 Aptamer as Functional Group -- 2.6.1 α-Thrombin -- 2.6.2 Insulin -- 2.7 MIPs as Functional Group -- References -- 3 Application of Nanomaterials to Separation of Phosphorylated Proteins -- 3.1 Introduction -- 3.2 IMAC-Based ; Nanomaterials -- 3.2.1 Ti4+-IMAC -- 3.2.2 Zr4+−IMAC -- 3.2.3 Other IMAC -- 3.2.4 Multi-IMAC -- 3.3 MOAC-Based Nanomaterials -- 3.3.1 Single MOAC -- 3.3.2 Multiple MOAC -- 3.4 Combination of IMAC and MOAC -- 3.4.1 Physical Combination -- 3.4.2 Chemical Combination -- 3.5 Amine-Based Nanomaterials -- 3.5.1 Guanidyl as Functional Group -- 3.5.2 Hydrazide as Functional Group -- 3.5.3 Polyethylenimine as Functional Group -- 3.5.4 Urea as Functional Group -- 3.5.5 Carbon Nitride as Functional Group -- 3.6 Others.; 3.6.1 4-(3-Acryloyl-Thioureido)-Benzoic Acid as Functional Group -- 3.6.2 Fluorous Derivatization -- 3.6.3 Epitope Imprinting -- References -- 4 Application of Nanomaterials to Separation of Glycosylated Proteins -- 4.1 Introduction -- 4.2 Hydrophilic Nanomaterials -- 4.2.1 Carbohydrate as Functional Group -- 4.2.2 Neutral Hydrophilic Polymer as Functional Group -- 4.2.3 Amino Acid as Functional Group -- 4.2.4 Zwitterionic Hydrophilic Polymer as Functional Group -- 4.2.5 Iminodiacetic Acid as Functional Group -- 4.3 Boronate Affinity Nanomaterials -- 4.3.1 Small-Molecule Boronic Acid as Functional Group -- 4.3.2 Boronic Acid Polymer as Functional Group -- 4.3.3 Boronic Acid-Based MIPs -- 4.4 Hydrazide-Based Nanomaterials -- References -- 5 Simultaneous Application of Nanomaterials to Separation of Phosphorylated and Glycosylated Proteins -- 5.1 Introduction -- 5.2 Hydrophilic MOAC -- 5.3 Hydrophilic IMAC -- 5.4 Combination of Boronic Acid and MOAC -- 5.5 Smart Polymer -- References -- 6 Application of Nanomaterials to Separation of Endogenous Peptides -- 6.1 Introduction -- 6.2 Separation of Endogenous Ordinary Peptides -- 6.2.1 Hydrophobic Mesoporous Silica -- 6.2.2 Mesoporous Carbon/Silica-Carbon -- 6.2.3 Hydrophobic COF -- 6.2.4 Metal Ion as Functional Group -- 6.2.5 Combination of Hydrophobicity and Metal Ion -- 6.3 Separation of Endogenous Phosphopeptides -- 6.3.1 Mesoporous IMAC -- 6.3.2 Mesoporous MOAC -- 6.4 Separation of Endogenous Glycopeptides/Glycans -- 6.4.1 Hydrophilic Mesoporous Silica -- 6.4.2 Hydrophilic MOF -- 6.4.3 Hydrophilic COF -- 6.4.4 Boronic Acid-Modified Mesoporous Silica -- 6.4.5 Mesoporous Carbon/Silica-Carbon -- References -- 7 Conclusion -- Index.