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1. |
Record Nr. |
UNINA9910324041203321 |
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Autore |
Barkhoff Jürgen |
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Titolo |
Traces du mesmérisme dans les littératures européennes du xixe siècle / / Ernst Leonardy, Marie-France Renard, Christian Drösch, Stéphanie Vanasten |
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Pubbl/distr/stampa |
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Bruxelles, : Presses de l’Université Saint-Louis, 2019 |
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ISBN |
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Descrizione fisica |
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1 online resource (284 p.) |
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Altri autori (Persone) |
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BrixMichel |
DierkensJean |
Gothot-MerschClaudine |
GruberBettina |
JacquesGeorges |
LeonardyErnst |
LogéTanguy |
MéheustBertrand |
MortierRoland |
RenardMarie-France |
RolandHubert |
SchraderHans-Jürgen |
VanderlindenSonja |
Van EyndeLaurent |
DröschChristian |
VanastenStéphanie |
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Disciplina |
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Soggetti |
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Mesmerism in literature |
European literature - 19th century - History and criticism |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Par la transmission du « magnétisme animal » à ses patients, le médecin Franz Anton Mesmer (1734-1815) crut avoir révolutionné l’art de guérir. L’influence de ses théories s’étendit rapidement à toute l’ |
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Europe. Bientôt, le débat déborde le cadre de la médecine pour s’élargir à la littérature et à la philosophie. Les contributions du présent volume confrontent l’influence du mesmérisme subie par des auteurs français à celle exercée sur des auteurs allemands. Cette comparaison permet de constater l’unité du courant mesmériste dans les diverses littératures européennes du xixème siècle mais témoigne aussi des spécificités nationales dans sa réception. La question de l’héritage légué par Mesmer à l’époque actuelle est évoquée en guise de conclusion. |
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2. |
Record Nr. |
UNINA9910137216403321 |
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Autore |
Rameshwar K Sharma |
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Titolo |
Ca2+ and Ca2+-interlocked membrane guanylate cyclase modulation of neuronaland cardiovascular signal transduction / / topic editors: Rameshwar K. Sharma, Wolfgang Baehr,Clint L. Makino and Teresa Duda |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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France : , : Frontiers Media SA, , 2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (185 pages) : illustrations; digital, PDF file(s) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Animal Biochemistry |
Human Anatomy & Physiology |
Health & Biological Sciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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The development of the field of membrane guanylate cyclase transduction system has been colorful, filled with exceptional historical events in cellular signaling research. From denial to resurgence, the field has branched in multiple directions. The signal transduction characteristics and signaling elements are unique. The field has established cyclic GMP as an ubiquitous intracellular second messenger, playing a critical role in the control of many physiological processes, including cardiac vasculature, smooth muscle relaxation, |
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blood volume, cellular growth, sensory transduction, neural plasticity, learning and memory. Unlike the three-component design of its predecessor: adenylate cyclase, G-protein and G-protein coupled receptor, the membrane guanylate cyclase transduction system consists of a single entity, a trans-membrane-spanning protein that serves as both a receptor and a signal transducer. Membrane guanylate cyclases exist in multiple forms. Each form translates the captured signal at a structurally conserved core catalytic site that resides in the intracellular domain. Yet the mechanism of capturing the signal is unique to each form. The surface receptor form uses its extracellular domain to capture hormonal signals; the Ca2+-modulated ROS-GC employs its intracellular domains; and the olfactory receptor ONE-GC captures odorant signals at its extracellular domain and amplifies them at multiple intracellular domains. The composition of the hormone receptor form differs from the ROS-GC and ONE-GC forms, consisting of a single polypeptide, that is both a signal receptor and the transducer. In contrast, both ROS-GC and ONE-GC are multi-component systems. A Ca2+ sensing subunit(s) captures the signal and transmits it to a companion guanylate cyclase, that transduces it. Moreover, the modes of signal transduction vary in ROS-GC and ONE-GC. ROS-GC is a direct transducer of Ca2+ signals but the Ca2+ sensors in ONE-GC only amplify the odorant signal received and transmitted by its extracellular domain. An additional refinement is that ROS-GC1 is a bimodal Ca2+ switch, turned “OFF” as intracellular [Ca2+] rises above 75 nM, but then turned back “ON” when [Ca2+] exceeds 345 nM. These modes occur uniquely in the outer segments and synapses of cones in rodent retinas. In a new paradigm change, the dogma has been shattered that the ANF hormone receptor guanylate cyclase, ANF-RGC, is the specific transducer of ANF alone. It is now known that ANF-RGC also transduces a Ca2+ signal. Ca2+ captured by its sensor neurocalcin δ (NCδ) directly activates the catalytic module of ANF-RGC. Accordingly, and impressively, targeted gene-deletion mouse model studies demonstrate that both pathways are linked with blood pressure regulation. Their disruption causes hypertension. Thus the ANF-RGC combines features of hormone receptor and ROS-GC forms of membrane guanylate cyclases. These studies also broaden the classification of the Ca2+ sensors. NCδ, classified as a neuronal calcium sensor, is more widespread. The general theme of this Research Topic is to present a comprehensive coverage of the expanding role being played by this beautifully designed transduction machinery. The reviews will cover its history to its present status, move on to theoretical and experimental investigations propelling the field in future directions, and provide illustrations where the field contributes to clinical medicine. |
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3. |
Record Nr. |
UNINA9910495835403321 |
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Autore |
Bourlet Caroline |
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Titolo |
Les limites de Paris (xiie-xviiie siècles) / Anne Conchon, Hélène Noizet, Michel Ollion |
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Pubbl/distr/stampa |
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Villeneuve d'Ascq, : Presses universitaires du Septentrion, 2017 |
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ISBN |
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Descrizione fisica |
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1 online resource (154 p.) |
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Altri autori (Persone) |
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ConchonAnne |
GuittonneauPierre-Henri |
Lyon-CaenNicolas |
MarraudMathieu |
NoizetHélène |
OllionMichel |
RousselDiane |
VidoniNicolas |
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Soggetti |
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Urban Studies |
Medieval & Renaissance Studies |
limite |
barrière |
enceinte |
Moyen-Âge |
période moderne |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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L'actualité de la création de la Métropole du Grand Paris qui redéfinit le périmètre de la capitale, resté inchangé depuis sa dernière modification en 1860, invite à une réflexion historique sur les limites de la ville. S’il s’agit d’un thème de recherches faisant l’objet de continuels renouvellements en géographie et en sociologie urbaine, la question des découpages parisiens reste relativement peu étudiée pour les périodes médiévale et moderne. Qu’elles circonscrivent la ville ou qu’ |
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elles la sillonnent, les limites constituent des facteurs essentiels à la compréhension et à l’interprétation des dynamiques urbaines. Étudier la façon dont elles sont vécues et perçues par les citadins permet en outre d’observer les fonctions diverses qu’elles jouent dans la construction des rapports sociaux et dans la territorialisation des pratiques. The recent creation of the metropolis of the Grand Paris, whose area is the same since 1860, encourages to an historial reflexion about the limits of the town, which is at the center of the biggest urban region in Europe since the Middle Ages. |
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