1.

Record Nr.

UNINA9910495223703321

Autore

Fraquelli Mirella

Titolo

Elastography of the liver and beyond / / Mirella Fraquelli

Pubbl/distr/stampa

Cham, Switzerland : , : Springer International Publishing, , [2021]

©2021

ISBN

3-030-74132-X

Descrizione fisica

1 online resource (283 pages)

Disciplina

616.362

Soggetti

Liver - Diseases - Immunological aspects

Liver - Diseases - Diagnosis

Malalties del fetge

Diagnòstic per la imatge

Immunologia

Llibres electrònics

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Intro -- Foreword -- Preface -- Contents -- Part I: Introduction to Elastography -- 1: Elastographic Measures: A Methodological Approach -- 1.1  Phase 0 -- 1.2  Phase 1 -- 1.3  Phase 2 -- 1.4  Phase 3 -- 1.5  Phase 4 -- 1.6  Conclusions -- References -- 2: Liver Stiffness: Thresholds of Health -- 2.1  Preamble: The Concept of Normality in Medicine -- 2.2  Healthy Ranges in Liver Disease Diagnostics -- 2.3  Definition of Healthy Ranges for Liver Stiffness -- 2.4  Conclusions -- References -- Part II: Liver Diseases -- 3: The Role of Transient Elastography for Fibrosis Staging in HCV-Related Chronic Liver Disease -- 3.1  Introduction -- 3.2  Assessment of Liver Disease Severity -- 3.2.1  Role of Liver Biopsy -- 3.2.2  Non-Invasive Assessment of Liver Fibrosis in CHC -- 3.3  Transient Elastography for the Assessment of Liver Fibrosis Prior to Antiviral Therapy -- 3.3.1  Combination Algorithms -- 3.3.2  TE vs. Other Elastography Techniques -- 3.4  Transient Elastography for the Assessment of Liver Fibrosis After SVR -- 3.5  Transient Elastography for Diagnosing Liver-Related Complications -- 3.5.1  Portal Hypertension -- 3.5.2  Gastro-Oesophageal Varices (GEV) -- 3.5.3  Hepatocellular Carcinoma (HCC) --



3.6  Transient Elastography to Determine Prognosis -- 3.7  Conclusions -- References -- 4: The Role of Elastography in HBV: Assessing Liver Fibrosis -- 4.1  Introduction -- 4.2  Liver Stiffness Cofactors and Confounders -- 4.3  TE in Untreated HBV Carriers -- 4.3.1  HBsAg Carriers Without Liver Disease -- 4.3.2  Untreated CHB Patients -- 4.4  TE in Treated CHB Patients -- 4.4.1  LS Kinetics During Antiviral Treatment -- 4.4.2  Correlation Between LS Changes During Treatment and CHB Outcomes -- 4.5  Conclusions -- References -- 5: The Role of Transient Elastography in NAFLD -- 5.1  Fibrosis in NAFLD: The Burden.

5.2  Transient Elastography: The Technique -- 5.2.1  The Procedure -- 5.2.2  Probes -- 5.2.3  The Role of Controlled Attenuation Parameter (CAP) -- 5.2.4  Limitations -- 5.3  Transient Elastography in NAFLD: The Quote -- 5.3.1  Diagnostic Accuracy -- 5.3.2  The Issue of Rule-In and Rule-Out -- 5.3.3  Confounding Factors -- 5.3.4  Liver Stiffness as Predictor of Liver Events -- 5.4  Conclusions -- References -- 6: Elastography in Liver-Transplanted Patients -- 6.1  Acute Rejection -- 6.2  Recurrent Hepatitis C -- 6.3  "Non-viral" Graft Disease After Transplantation -- 6.4  Non-alcoholic Fatty Liver Disease (NAFLD) -- 6.5  Elastography Outcome After Liver Transplantation -- 6.6  Spleen Stiffness and Liver Transplant -- References -- 7: Elastography in Autoimmune Liver Diseases -- 7.1  Introduction -- 7.2  Primary Biliary Cholangitis -- 7.3  Primary Sclerosing Cholangitis -- 7.4  Autoimmune Hepatitis -- 7.5  Conclusions -- References -- 8: Transient Elastography for the Diagnosis of Liver Fibrosis and Cirrhosis in People with Alcohol-Associated Liver Disease -- 8.1  Introduction -- 8.2  Liver Fibrosis and Staging Assessment -- 8.3  Noninvasive Laboratory Tests and Machine-Based Techniques for Assessment of Hepatic Fibrosis -- 8.4  Transient Elastography for Fibrosis Assessment in ALD -- 8.5  Discussion -- 8.6  Conclusion -- References -- 9: Elastography After Treatment and During Follow-Up -- 9.1  Introduction -- 9.2  Chronic HCV Infection -- 9.3  Liver Stiffness Changes Following IFN-Based Regimens -- 9.3.1  Studies with Histological Confirmation -- 9.3.2  Studies Without Histological Confirmation -- 9.4  Liver Stiffness Changes Following DAA Regimens -- 9.4.1  Studies with Histological Confirmation -- 9.4.2  Studies Without Histological Confirmation -- 9.5  HBV Infection -- 9.6  Conclusions -- References.

10: Elastography Methods to Assess Chronic Liver Diseases: A Critical Comparison -- 10.1  Available Elastography Methods -- 10.1.1  Principle and Characteristics -- 10.1.2  Reliability, Failure Rates, and Applicability of Elastography Methods -- 10.1.3  Limitations of Liver Stiffness Measurement with Different Methods -- 10.1.4  Respective Advantages and Inconveniences of the Different Methods -- 10.2  Performance of Elastography Techniques for Diagnosing Cirrhosis -- 10.3  Comparison of Elastography Methods and Other Noninvasive Tests -- 10.4  New Technical Developments -- 10.4.1  Controlled Attenuation Parameter (CAP) -- 10.4.2  3D MRE -- 10.4.3  Multifrequency MRE -- 10.5  Conclusions -- References -- 11: The Assessment of Portal Hypertension -- 11.1  General Concepts on the Pathophysiology of Portal Hypertension in Advanced Chronic Liver Disease -- 11.1.1  The Standard Assessment of Portal Hypertension -- 11.2  Liver Elastography (Transient, US-Based) as a Diagnostic and Prognostic Tool in PH -- 11.2.1  Clinically Significant Portal Hypertension and Liver Elastography -- 11.2.2  Gastroesophageal Varices and Liver Elastography -- 11.3  The Spleen in Advanced Chronic Liver Disease -- 11.3.1  Spleen Stiffness Measurement Techniques -- 11.3.2  Spleen Stiffness and Fibrosis



Degree Evaluation -- 11.4  Spleen Elastography as a Diagnostic and Prognostic Tool in Portal Hypertension -- 11.4.1  Spleen Stiffness and Gastroesophageal Varices -- 11.4.2  Spleen Stiffness and Hepatic Decompensation -- 11.4.3  Spleen Stiffness in Monitoring Outcome After Interventional Procedure for PH -- References -- 12: Assessing Disease Severity and Prognosis -- 12.1  Introduction -- 12.2  Prediction of First Clinical Decompensation -- 12.2.1  Liver Stiffness -- 12.2.2  Spleen Stiffness -- 12.2.3  Combination Tests -- 12.3  Prediction of Further Clinical Decompensation.

12.4  Prediction of Development of Hepatocellular Carcinoma -- 12.4.1  Prediction of HCC Recurrence After Treatment -- 12.5  Survival -- 12.6  Conclusion -- References -- Part III: Extrahepatic Diseases: Pancreas -- 13: Pancreas: Transabdominal Ultrasound-Based Elastography -- 13.1  Introduction -- 13.2  Pancreatic Stiffness Measurement in Benign Pancreatic Diseases -- 13.2.1  Chronic Pancreatitis and Alcohol-Related Disease -- 13.2.2  Acute Pancreatitis -- 13.2.3  Application in Surgery -- 13.2.4  Cystic Fibrosis and Diabetes -- 13.3  Pancreatic Stiffness Measurement in Focal Pancreatic Lesions -- 13.3.1  Evaluation of Solid Lesions -- 13.3.2  Evaluation of Cystic Lesions -- 13.4  Limitations of Transabdominal PS Assessment -- References -- 14: Endoscopic Ultrasound Elastography in Pancreatic Diseases -- 14.1  Introduction -- 14.2  Focal Lesions -- 14.2.1  Pancreatic Ductal Adenocarcinoma -- 14.2.2  Pancreatic Neuroendocrine Neoplasms -- 14.3  Parenchymal Diseases -- 14.3.1  Chronic Pancreatitis -- 14.3.2  Autoimmune Pancreatitis -- 14.4  Conclusion -- References -- Part IV: Extrahepatic Diseases: Bowel -- 15: Application of Elastography in Patients with Inflammatory Bowel Diseases -- 15.1  Introduction -- 15.2  Elastography in Inflammatory Bowel Diseases: First Data from Animal Models and Surgical Series -- 15.3  Elastography and Crohn's Disease: Assessing Fibrotic Strictures -- 15.3.1  Strain Elastography -- 15.3.2  Acoustic Radiation Force Impulse: Shear Wave Elastography -- 15.3.3  Comparison Between Elastographic Techniques -- 15.4  Elastography as a Predictor of Therapy Outcome in Crohn's Disease? -- 15.5  Other Applications of Elastography -- 15.5.1  Pediatric Crohn's Disease -- 15.5.2  Ulcerative Colitis -- 15.6  Summary -- References -- Part V: Spleen Involvement in Liver and Non-Liver Diseases.

16: Liver and Spleen Stiffness in Vascular Liver Disease -- 16.1  Introduction -- 16.2  Part I: Liver and Spleen Stiffness in Patients with Budd-Chiari Syndrome -- 16.3  Part II: Liver and Spleen Stiffness in Patients Non-cirrhotic Portal Hypertension -- 16.4  Part III: Liver Stiffness in Patients with Sinusoidal Obstruction Syndrome (SOS/VOD) -- References -- 17: Liver and Spleen Stiffness in Hematological Diseases -- 17.1  Liver Elastography in Hematological Diseases -- 17.2  Spleen Elastography in Hematological Diseases -- References -- Part VI: Case Studies -- 18: Case 1: Unexpected High Liver Stiffness as a Warning Sign -- 18.1  Case Report -- 18.2  Comments -- References -- 19: Case 2: Liver and Spleen Stiffness After TIPS -- 19.1  Case Report -- 19.2  Comments -- References -- 20: Case 3: Congestive Hepatopathy with High Liver and Spleen Stiffness in a 17 Years Old Male Patient -- 20.1  Case Report -- 20.2  Comments -- References -- 21: Case 4: To Operate or Not to Operate? A Case of Crohn's Disease When Elastography Helped -- 21.1  Case Report -- References.