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1. |
Record Nr. |
UNINA9910490024603321 |
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Autore |
Carlberg Carsten |
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Titolo |
Cancer Biology: How Science Works / / by Carsten Carlberg, Eunike Velleuer |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (179 pages) |
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Disciplina |
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Soggetti |
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Cancer |
Genetics |
Molecular biology |
Cancer Biology |
Genetics and Genomics |
Molecular Biology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies. |
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Sommario/riassunto |
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Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under |
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control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information. |
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2. |
Record Nr. |
UNINA9910865242803321 |
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Autore |
Kulkarni Shrikaant |
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Titolo |
Biosystems, Biomedical & Drug Delivery Systems : Characterization, Restoration and Optimization / / edited by Shrikaant Kulkarni, A. K. Haghi, Sonali Manwatkar |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024 |
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ISBN |
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Edizione |
[1st ed. 2024.] |
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Descrizione fisica |
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1 online resource (376 pages) |
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Collana |
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Biomedical and Life Sciences Series |
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Altri autori (Persone) |
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HaghiA. K |
ManwatkarSonali |
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Disciplina |
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Soggetti |
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Biophysics |
Imaging systems in biology |
Biomaterials |
Pharmacology |
Bioanalysis and Bioimaging |
Biological Imaging |
Biomedical Materials |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Editorial: Future of Novel Technologies in Biosystems, Biomedicine, and Drug Delivery -- Part I; Novel Technologies in Biosystems, Biomedicine, and Drug Delivery: Characterization -- 2. Characterization Tools for Current Drug Delivery Systems -- 3. Characterization of Transdermal Drug Delivery Systems: Retrospect and Future Prospects -- 4. Analytical Tools for the Characterization of Nasal Spray Drug Products -- Part II: Novel Technologies in Biosystems, Biomedicine, and Drug Delivery: Restoration -- 5. AI-Enabled Models in the Restoration of Drug Efficacy and Drug Design -- 6. Restoration and Sustenance of Nano drug delivery systems: potential, Challenges, and limitations -- 7. Artificial Intelligence and Machine Learning in Restoring and Strengthening HealthCare -- Part III: Novel Technologies in Biosystems, Biomedicine, and Drug Delivery: Optimization -- 8. Optimizing Oncology Tools: Organ-on-a-clip alternative to animal model -- 9. Optimizing Drug Synthesis: AI-Powered Kinetics study in Pharmaceutical Research -- 10. In Silico Toxicological Protocols Optimization for the Prediction of Toxicity of Drugs -- 11. Optimizing Healthcare Throughput: The Role of Machine Learning and Data Analytics -- Part IV: Novel Technologies in Biosystems, Biomedicine, and Drug Delivery: Applications -- 12. Applications of AI-based Models in the field of Biomedicine -- 13. Application of New Biological Entities (NBEs) as Therapeutics -- 14. Applications of Computational Tools in the Prediction of Toxicity -- 15. Application of Peptides for the treatment of diabetes: A plant-based bioactive material -- 16. Regenerative Medicines: Application to Degenerative Diseases and Disorders. |
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Sommario/riassunto |
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The book gives an insight into the thorough study and examination of incumbent biosystems, their present status and disruption in their integrity, causes and effects, measures to be taken for their characterization and restoration apart from advances and applications in the field of biosciences, drug design, discovery, bio-systems, biomedical and drug delivery technologies, tools in particular. The book collates information from several disciplines, such as chemistry, biology, material science, engineering, statistics, biomedicine, genetics, etc., as the subject in question is a confluence of many disciplines exhibiting numerous applications such as bioimaging, novel biological agents, synthesis, discovery testing, characterization of drugs right from selecting a suitable precursor to discovering and designing a drug following a correct synthetic route, adoption of computer simulation-based models, AI/ML-based models, application of statistical tools in analyzing and interpreting data, design, multi-functional, and operational drug delivery systems, their bio-compatibility, capacity of carrying and release of drug reproducibly etc. The book is helpful to postgraduate students, research scholars, academicians, and scientists from the pharmaceutical, biotechnology, and chemical engineering domains. The book covers a conceptual understanding of the exploration of drugs in unity with the applications desired, sound bio-system development, and carriers for drug and supplement delivery. |
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