Intro -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1 Introduction to Cancer -- 1.1 The Global Burden of Cancer -- 1.2 Categorization and Diagnosis of Tumors -- 1.3 Crucial Transitions in Cancer -- 1.4 Causes of Cancer -- 1.5 Cancer Prevention -- Further Reading -- 2 Oncogenes and Signal Transduction -- 2.1 Cellular Transformation -- 2.2 Activating Oncogenes in Signal Transduction Pathways -- 2.3 Oncogenic Translocations and Amplifications -- 2.4 The Hallmarks of Cancer Concept -- Further Reading -- 3 Tumor Suppressor Genes and Cell Fate Control -- 3.1 p53 - A Master Example -- 3.2 Tumor Suppressors and Oncogenes in Cell Cycle Control -- 3.3 Tumor Suppressor Inhibition and Cancer Onset -- Further Reading -- 4 Multi-step Tumorigenesis and Genome Instability -- 4.1 Characteristics of Tumor Growth -- 4.2 Multi-step Tumorigenesis -- 4.3 Genome Instability -- 4.4 Cancer Driver Mutations and Genes -- Further Reading -- 5 Cancer Genomics -- 5.1 Human Genetic Variation and Cancer Susceptibility -- 5.2 The Cancer Genome -- 5.3 Cancer Genome Projects -- Further Reading -- 6 Cancer Epigenomics -- 6.1 Epigenetic Mechanisms of Cancer -- 6.2 DNA Methylation and Cancer
-- 6.3 Chromatin Changes and Cancer -- 6.4 Epigenetic Reprogramming in Cancer -- Further Reading -- 7 Aging and Cancer -- 7.1 Central Role of Aging During Chronic Diseases -- 7.2 The Hallmarks of Aging -- 7.3 Epigenetics of Aging -- 7.4 Telomeres and Replicative Immortality -- Further Reading -- 8 Tumor Microenvironment -- 8.1 The Impact of the Wound Healing Program for Cancer -- 8.2 Cell Types of the Tumor Microenvironment -- 8.3 Inducing Angiogenesis -- 8.4 Tumor-Promoting Inflammation -- 8.5 Deregulating Cellular Energetics -- Further Reading -- 9 Metastasis and Cachexia -- 9.1 The Metastatic Cascade -- 9.2 Epithelial-Mesenchymal Transition -- 9.3 Metastatic Colonization.
9.4 Cachexia -- Further Reading -- 10 Cancer Immunity -- 10.1 Outline of Cancer Immunity -- 10.2 Recognition of Tumor Antigens -- 10.3 Monoclonal Antibodies in Cancer Immunotherapy -- 10.4 Immune Cell Therapies -- Further Reading -- 11 Architecture of Cancer Therapies -- 11.1 Classical Cancer Treatments -- 11.2 Targeted Therapies -- 11.3 Precision Oncology -- Further Reading -- Glossary.