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Record Nr. |
UNINA9910484775403321 |
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Titolo |
Aptamers for medical applications : from diagnosis to therapeutics / / Yiyang Dong, editor |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , [2021] |
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©2021 |
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ISBN |
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Descrizione fisica |
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1 online resource (xiii, 462 pages) : illustrations |
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Disciplina |
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Soggetti |
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Oligonucleotides - Biotechnology |
Oligonucleotides - Therapeutic use |
Biomedical engineering |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Intro -- Preface -- Introduction -- Contents -- About the Editor -- 1 Introduction of Aptamer, SELEX, and Different SELEX Variants -- 1.1 Introduction -- 1.2 Systematic Evolution of Ligands by EXponential Enrichment (SELEX) -- 1.3 Different SELEX Variants for Selection Rationalization -- 1.3.1 Reducing Screening Rounds -- 1.3.2 Furnishing More Targets Applicability -- 1.3.3 Simplifying Operations -- 1.3.4 Improving the Specificity of the Aptamer -- 1.3.5 Introducing Evaluation into the Selection Process -- 1.3.6 Other Selection Strategies -- 1.4 Perspectives -- References -- 2 Aptamer-Based Probes for Molecular Imaging -- 2.1 Introduction -- 2.2 Nuclear Imaging -- 2.2.1 Single Photon Emission Computed Tomography (SPECT) -- 2.2.2 Positron Emission Tomography (PET) -- 2.3 Magnetic Resonance Imaging -- 2.4 Ultrasound Imaging -- 2.5 Fluorescence Imaging -- 2.6 Multimodal Imaging -- 2.7 Conclusions and Perspectives -- References -- 3 Aptamer-Based Point of Care Testing Schemes -- 3.1 Introduction -- 3.2 Aptamers as Sensing Probes in POCT -- 3.3 Aptasensors-Based POCT -- 3.3.1 Aptamer-Based Lateral Flow POCT Platforms -- 3.3.2 Interferometry -- 3.3.3 DNA Origami Nanobox -- 3.3.4 Capacitive Aptasensors -- 3.3.5 Smartphone Enabled Aptasensors -- 3.3.6 Microchannels/Microfluidics -- 3.3.7 Microbeads and Nanomaterial-Based Aptasensors -- 3.3.8 Multiple Aptasensing Platforms -- 3.4 |
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