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Record Nr. |
UNIBAS000041214 |
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Autore |
Arguedas, José María |
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Titolo |
Los ríos profundos / José María Arguedas ; edición de Ricardo González Vigil |
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ISBN |
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Descrizione fisica |
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Collana |
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Disciplina |
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Lingua di pubblicazione |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9911018799203321 |
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Titolo |
Protein-ligand interactions from molecular recognition to drug design / / edited by H.-J. Bohm and G. Schneider |
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Pubbl/distr/stampa |
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Weinheim, : Cambridge, : Wiley-VCH, 2003 |
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ISBN |
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1-280-52057-4 |
9786610520572 |
3-527-60551-7 |
3-527-60181-3 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (264 p.) |
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Collana |
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Methods and Principles in Medicinal Chemistry ; ; v.27 |
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Altri autori (Persone) |
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BohmHans-Joachim |
SchneiderGisbert <1965-> |
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Disciplina |
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Soggetti |
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Ligand binding (Biochemistry) |
Biochemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 1.1 Introduction; 1.2 Major Contributions to Protein-Ligand Interactions; 1.3 Description of Scoring Functions for Receptor-Ligand Interactions; 1.3.1 Force Field-based Methods; 1.3.2 Empirical Scoring Functions; 1.3.3 Knowledge-based Methods; 1.4 Some Limitations of Current Scoring Functions; 1.4.1 Influence of the Training Data; 1.4.2 Molecular Size |
1.4.3 Water Structure and Protonation State1.5 Application of Scoring Functions in Virtual Screening and De Novo Design; 1.5.1 Successful Identification of Novel Leads Through Virtual Screening; 1.5.2 De novo Ligand Design with LUDI; 1.6 Outlook; 1.7 Acknowledgments; 1.8 References; 2 Introduction to Molecular Recognition Models; 2.1 Introduction and Scope; 2.2 Additivity of Pairwise Interactions - The Chelate Effect; 2.3 Geometric Fitting: The Hole-size Concept; 2.4 Di- and Polytopic Interactions: Change of Binding Mechanism with Different Fit; 2.5 Deviations from the Lock-and-Key Principle |
2.5.1 Strain in Host-Guest Complexes2.5.2 Solvent Effects; 2.5.3 Enthalpy/Entropy Variations; 2.5.4 Loose Fit in Hydrophobically Driven Complex Formation; 2.6 Conformational Pre-organization: Flexible vs. Rigid Hosts; 2.7 Selectivity and Stability in Supramolecular Complexes; 2.8 Induced Fit, Cooperativity, and Allosteric Effects; 2.9 Quantification of Non-covalent Forces; 2.9.1 Ion Pairs and Electrostatic Donor-Acceptor Interactions; 2.9.2 Hydrogen Bonds; 2.9.3 Weak Hydrogen Bonds: The Use of Intramolecular ""Balances"; 2.9.4 Polarization Effects; 2.9.5 Dispersive Interactions |
2.10 Conclusions2.11 References; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 3.1 Introduction; 3.2 Basic Thermodynamics of Protein-Ligand Interactions; 3.3 Measurement of Thermodynamic Parameters; 3.3.1 Calorimetric Determination of Thermodynamic Parameters; 3.3.2 van't Hoff Determination of Thermodynamic Parameters; 3.3.2.1 Relationship to Equilibrium Constant; 3.3.2.2 Obtaining the Equilibrium Constant; 3.4 Applications; 3.4.1 Calorimetric Determination of Thermodynamic Parameters; 3.4.2 van't Hoff Determination of Thermodynamic Parameters |
3.5 Caveats3.6 Summary; 3.7 References; 4 The Biophore Concept; 4.1 Introduction; 4.2 Methodology for Pharmacophore Detection and Searching; 4.2.1 Definition of Pharmacophoric Groups; 4.2.2 Ligand-based Methods for Pharmacophore Perception; 4.2.3 Protein Structure-based Pharmacophore Perception; 4.2.4 Methods for Pharmacophore Searching; 4.3 Pharmacophore Fingerprints; 4.4 Applications of the Biophore Concept; 4.4.1 Lead Generation; 4.4.2 Multi-pharmacophore Descriptors in Diversity Analysis and Library Design; 4.4.3 Structure-based Design; 4.5 The Biophore Concept in ADME Prediction |
4.6 Summary |
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Sommario/riassunto |
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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular |
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design make a large contributio |
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3. |
Record Nr. |
UNINA9910484573003321 |
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Titolo |
Food, Nutrition and the Media / / edited by Valentina Marinescu |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Palgrave Macmillan, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (329 pages) : illustrations |
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Disciplina |
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Soggetti |
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Communication |
Mass media - Political aspects |
Science - Social aspects |
Media and Communication |
Media Policy and Politics |
Science and Technology Studies |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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1. Introduction -- 2. Food, nutrition and media -- 3. The comparative analysis of media coverage and scientific literature on food and nutrition: The case of Eastern European Countries -- 4. “Nutrition”: thematic coverage in Estonian scientific and mass media -- 5. Analysis of occurrence of “food” and “nutrition” phrases in Polish scientific articles.Case study: overweight and obesity among children -- 6. Mediatic coverage of scientific researches published in the Republic of Moldova on “nutrition”and “food”subjects -- 7. A Comparative Conceptual Map of “Alimentation” and “Nutrition” in Romania -- 8. Media coverage of the topic “nutrition” and related issues in German online news -- 9. From nutritious banks for the poor to Top 10 meals against love pain – Food in Bulgarian media as an entertaining zone -- 10. “Nutrition” and “food” in online media in the Republic of Moldova. |
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Content analysis -- 11. A critical analysis of Romanian media representations of food - A qualitative and quantitative perspective -- 12. Media coverage of food issues in Romania: A longitudinal analysis -- 13. But Where are the Tastes of Yesteryear? Mapping the Commodification of Communist Brands -- 14. Experiencing the Spectacle of Fine Dining. New Forms of Festivity in Sofia, Bulgaria and Diversion of Public Space -- 15. Figurative reconstruction in food and healthcare advertising -- 16. Culinary Discourse in Contemporary South Korea -- 17. Romanian online media and public health threads: Case study incidents with food in urban areas -- 18. An argument for a broader definition for Food Literacy: Findings from a systematic review -- 19. Educating through television in health and nutrition -- 20. Food consumption behaviour and lifestyle - a cross-national study in Romania, Bulgaria and the Republic of Moldavia -- 21. Associations between Social Media Use and Loneliness, Body Image and Disordered Eating: A Qualitative Study of British Young Adults -- 22. Relationship between self-regulated eating behaviour and eHealth literacy: A Confirmatory Factorial Analysis. |
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Sommario/riassunto |
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Placed at the crossroads of diverse disciplines – medical sciences, information and communication science, sociology of food, agricultural sciences – this book focuses on media, food and nutrition. Contributors to this volume come from different countries including the United Kingdom, Germany, Mexico and Romania, and consider comparatively their native cultures. The book answers several questions: How are food and nutrition made visible and publicized? What is the role of media in relation to food and nutrition? What are the strategies of discourses surrounding food and nutrition within new public spaces? |
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