Dynamic studies in biology [[electronic resource] ] : phototriggers, photoswitches and caged biomolecules / / edited by Maurice Goeldner, Richard Givens

• Record Nr.: UNINA9910830086703321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, c2005
• ISBN: 1-280-52060-4; 9786610520602; 3-527-60559-2; 3-527-60554-1
• Descrizione fisica: 1 online resource (587 p.)
• Altri autori (Persone): GoeldnerMaurice; GivensRichard
• Disciplina: 547.2
• Soggetti: Photobiochemistry; Biomolecules - Separation; Protective groups (Chemistry)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Dynamic Studies in Biology Phototriggers, Photoswitches and Caged Biomolecules; Contents; Foreword; Preface; List of Authors; 1 Photoremovable Protecting Groups Used for the Caging of Biomolecules; 1.1 2-Nitrobenzyl and 7-Nitroindoline Derivatives; 1.1.1 Introduction; 1.1.1.1 Preamble and Scope of the Review; 1.1.1.2 Historical Perspective; 1.1.2 Synthetic Considerations; 1.1.3 Survey of Individual Caged Compounds and Caging Groups; 1.1.3.1 2-Nitrobenzyl Cages; 1.1.3.1.1 Mechanistic Aspects of Photocleavage and By-Product Reactions of 2-Nitrobenzyl Cages; 1.1.3.1.2 Representative Survey of Nitrobenzyl-Caged Compounds1.1.3.2 7-Nitroindoline Cages; 1.1.3.2.1 Mechanistic and Structural Aspects of Photochemical Cleavage of 1-Acyl-7-nitroindolines; 1.1.3.2.2 Survey of 7-Nitroindoline Caged Compounds; 1.1.4 Conclusion; References; 1.2 Coumarin-4-ylmethyl Phototriggers; 1.2.1 Introduction; 1.2.2 Spectroscopic and Photochemical Properties; 1.2.2.1 Overview; 1.2.2.2 Phototriggers; 1.2.2.2.1 MCM Groups: 7-Alkoxy-; Substituted Coumarins; 1.2.2.2.2 DMCM Groups: 6,7-Dialkoxy-Substituted Coumarins; 1.2.2.2.3 Bhc Groups: 6-Bromo-7-alkoxy-Substituted Coumarins; 1.2.2.2.4 DEACM Groups: 7-Dialkylamino-Substituted Coumarins1.2.2.3 Target Molecules; 1.2.2.3.1 Phosphates; 1.2.2.3.2 Carboxylates and Sulfates; 1.2.2.3.3 Amines; 1.2.2.3.4 Alcohols and Phenols; 1.2.2.3.5 Carbonyl Compounds; 1.2.3 Synthesis; 1.2.3.1 Synthesis of Precursor Molecules (Caging Agents); 1.2.3.1.1 Phosphates; 1.2.3.1.2 Carboxylates; 1.2.3.1.3 Amines; 1.2.3.1.4 Alcohols and Phenols; 1.2.4 Applications; 1.2.5 Conclusion and Perspective; References; 1.3 p-Hydroxyphenacyl: a Photoremovable Protecting Group for Caging Bioactive Substrates; 1.3.1 Introduction and History; 1.3.2 p-Hydroxyphenacyl1.3.2.1 General Physical and Spectroscopic Properties; 1.3.2.2 Synthesis of pHP-Caged Substrates; 1.3.3 Mechanistic Studies; 1.3.3.1 A Triplet "Photo-Favorskii" Rearrangement; 1.3.3.2 Role of the Triplet Phenol; 1.3.3.3 Correlation of the (3)pK(a) with the Quantum Efficiency; 1.3.4 Applications; 1.3.4.1 Neurotransmitter Release; 1.3.4.2 Peptide Release; 1.3.4.3 Nucleotide Release; 1.3.4.4 Enzyme Photoswitches; 1.3.5 Advantages and Limitations; References; 1.4 Caging of ATP and Glutamate: a Comparative Analysis; 1.4.1 Introduction; 1.4.2 General Properties for Caging Groups1.4.3 Caged-ATP; 1.4.3.1 Introduction; 1.4.3.2 Syntheses of the P(3)-caged ATP Derivatives; 1.4.3.3 General Properties of the Caged-ATP Molecules; 1.4.3.4 Conclusion; 1.4.4 Caged Glutamate; 1.4.4.1 Introduction; 1.4.4.2 Syntheses of the Caged Glutamate Derivatives; 1.4.4.3 General Properties of the Caged-Glutamate Molecules; 1.4.4.4 Conclusion; Abbreviations; References; 2 Mechanistic Overview of Phototriggers and Cage Release; 2.1 Introduction; 2.2 Major Photoremovable Protecting Groups; 2.2.1 2-Nitrobenzyl (2-NB); 2.2.1.1 The Reactive Excited State; 2.2.1.2 The aci-Nitro Intermediate
• Sommario/riassunto: With contributions by more than 30 expert researchers, this handbook covers the whole spectrum from chemistry to cell biology and from theory to application. In so doing, it deals with a broad range of topics from the chemistry and biophysics of caged compounds to their application in time-resolved studies, comparing the properties of different caging groups. The authors describe in detail light-activation of proteins as well as nucleic acids, while a special section is devoted to multiphoton phototriggers.A must-have for every biochemist, biophysicist and molecular biologist developing an

Learning in the Synergy of Multiple Disciplines : 4th European Conference on Technology Enhanced Learning, EC-TEL 2009 Nice, France, September 29--October 2, 2009 Proceedings / / edited by Ulrike Cress, Vania Dimitrova, Marcus Specht

• Record Nr.: UNINA9910484462203321
• Pubbl/distr/stampa: Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2009
• ISBN: 3-642-04636-3
• Edizione: [1st ed. 2009.]
• Descrizione fisica: 1 online resource (XVIII, 813 p.)
• Collana: Programming and Software Engineering, , 2945-9168 ; ; 5794
• Classificazione: DAT 030f; SS 4800
• Altri autori (Persone): CressUlrike; DimitrovaV; SpechtMarcus
• Disciplina: 378.1734467822gerDNB
• Soggetti: Education - Data processing; Computers and civilization; Digital humanities; User interfaces (Computer systems); Human-computer interaction; Microcomputers; Interactive multimedia; Multimedia systems; Computers and Education; Computers and Society; Digital Humanities; User Interfaces and Human Computer Interaction; Personal Computing; Media Design
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Keynotes -- Adaptation and Personalisation -- Interoperability, Semantic Web, Web 2.0 -- Data Mining and Social Networks -- ; Collaboration and Social Knowledge Construction -- Learning Communities and Communities of Practice -- Learning Contexts -- Problem and Project-Based Learning, Inquiry Learning -- Learning Design -- Motivation, Engagement, Learning Games -- Human Factors and Evaluation -- Posters.
• Sommario/riassunto: This book constitutes the refereed proceedings of the 4th European Conference on Technology Enhanced Learning, EC-TEL 2009, held in Nice, France in September/October 2009. The 35 revised full papers, 17 short papers, and 35 posters presented were carefully reviewed and selected from 136 paper submissions and 22 poster submissions. The papers are organized in topical sections on adaptation and personalization, interoperability, semantic Web, Web 2.0., data mining and social networks, collaboration and social knowledge construction, learning communities and communities of practice, learning contexts, problem and project-based learning, inquiry, learning, learning design, motivation, engagement, learning games, and human factors and evaluation.