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Record Nr. |
UNINA990005786310403321 |
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Autore |
Jäsche, Gottlob Benjamin |
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Titolo |
Einleitung zu einer Architektonik der Wissenschaften nebst einer Skiagraphie und allgemeinen tafel des gesammten systems menschlicher Wissenscaften nach architektonischem Plane : Zunächst zum Gebrauche für seine encyklopädischen Vorlesungen / von Gottlob Benj. Jäsche |
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Bruxelles : Culture et Civilisation, 1973 |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910484000003321 |
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Autore |
Bremner John |
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Titolo |
Multiple action-based design approaches to antibacterials / / John Bremner |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , [2021] |
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©2021 |
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ISBN |
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Descrizione fisica |
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1 online resource (xiii, 193 pages) : illustrations |
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Disciplina |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Intro -- Preface -- Contents -- About the Author -- 1 Antibacterials -- 1.1 Bacteria -- 1.2 Antibacterial Action -- 1.3 Bacterial Resistance to Antibacterials -- 1.3.1 Introduction to Key Resistance Mechanisms -- 1.3.2 Resistance and Resilience -- 1.3.3 The Gram-Negative Challenge -- 1.3.4 Other Survival Strategies -- 1.4 Approaches to Meeting Needs -- 1.5 Ways to Achieve Multi-action Effects -- 1.6 Bacterial Over Host Selectivity -- References -- 2 Antibacterial Combinations -- 2.1 Introduction -- 2.1.1 Dual Combinations Resulting in Two Actions -- 2.1.2 Dual Combinations Resulting in Three or More Actions -- 2.1.3 Triple Combinations Resulting in Three or More Actions -- 2.1.4 Quadruple Combinations with Four or More Actions -- 2.1.5 Pentuple Combinations -- 2.2 Summary -- References -- 3 Single Molecule Non-cleavable Multiply Active Antibacterials -- 3.1 Introduction to General Design Considerations -- 3.1.1 General Approaches to Hybrids -- 3.1.2 Factors in Antibacterial Hybrid Design -- 3.2 Designing for Mainly Dual Activity -- 3.2.1 Dual Action Antibacterial Hybrids -- 3.2.2 Examples of Dual Action Agents from Nature -- 3.2.3 Berberine as a Starting Point for Design -- 3.3 Triple Action Antibacterial Hybrid Agents -- 3.3.1 General Points -- 3.3.2 Potential Design Based on Pharmacophoric Elements -- 3.3.3 Established and Potential Single Molecule Triple Action or Interaction Agents -- 3.3.4 Designing Potential New Non-cleavable Triple Action Agents -- 3.4 More Than Triple Action Hybrid Agents -- References -- |
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4 Design Principles and Development of Prodrugs for Multiply Active Antibacterials -- 4.1 Definitions -- 4.1.1 Carrier-Linked Prodrugs (Carrier Prodrugs) -- 4.1.2 Bioprecursor Prodrugs -- 4.2 Introduction to Prodrugs for Triple or Higher Action Antibacterials -- 4.2.1 Design Considerations. |
4.2.2 Classification and Examples of Cleavable Types for Triple or Higher Action -- 4.2.3 Cleavable Type I -- 4.2.4 Cleavable Type II -- 4.2.5 Cleavable Type III -- 4.2.6 Cleavable Type IV -- 4.3 Release Mechanisms and Prodrug Design -- 4.3.1 Biological -- 4.3.2 Chemical -- 4.3.3 Physical -- 4.4 Metabolism Activated Multi-targeting -- 4.5 Conclusion -- References -- 5 Future Possibilities -- 5.1 Introduction -- 5.2 New Combinations and Single Molecules with Multi-activity Development Potential -- 5.2.1 Combinations -- 5.2.2 Hybrid Molecule Possibibilities -- 5.3 Search for Different Chemical Structure Types -- 5.3.1 In Silico Advances -- 5.4 New Modes of Action/New Targets -- 5.5 DNA and RNA Level Modulation -- 5.6 Proteins and Antibacterials -- 5.7 Concluding Remarks -- References -- Index. |
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3. |
Record Nr. |
UNINA9910416137303321 |
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Autore |
Theorell Töres |
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Titolo |
Handbook of Socioeconomic Determinants of Occupational Health : From Macro-level to Micro-level Evidence / / edited by Töres Theorell |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (37 illus., 11 illus. in color. eReference.) |
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Collana |
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Handbook Series in Occupational Health Sciences, , 2730-7417 |
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Disciplina |
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Soggetti |
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Psychology, Industrial |
Occupational health services |
Medical economics |
Work and Organizational Psychology |
Occupational Health |
Health Economics |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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The impact of socio-political upheaval: Russia and Eastern Europe -- Precarious employment in low and middle income countries -- Downsizing, restructuring and ‘survivor disease’ -- Interactions of work and health: an economic perspective -- Gender perspectives on employment and health -- Impacts of climate change on working people -- Social inequalities in health in older people or people after retirement -- Social inequalities in the transition from work to retirement -- From national labor, economic and social policies to individual working conditions: multilevel concepts, evidence and challenges -- The role of international organizations -- The social distribution of occupational hazards -- Occupational noise -- Shift work -- Long working hours -- Under- and over-employment -- Physical activity at work -- Job insecurity -- Job intensity: evidence from high income countries -- Job intensity: evidence from middleand low income countries -- Impact of digitalization on work and employment -- Early life conditions and critical employment trajectories -- Demand-control-support -- Effort-reward imbalance -- Organizational injustice -- Job demands and resources -- Psychosocial safety climate -- Social conflicts and offense to self -- Work-life balance: Definitions, Causes, and Consequences -- Job interventions for improvement of management by means of art experiences -- Organizational-level interventions -- Financial gains, possibilities and limitations of improving occupational health at the company level -- Health economic evaluation of workplace health promotion -- Stress disequilibrium -- Regenerative physiology counteracting damaging effects of long-lasting energy mobilisation -- Work stress and autonomic nervous system activity -- Work stress, immune and inflammatory markers -- Work stress and health-adverse behaviors. |
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Sommario/riassunto |
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This handbook provides a summary of more than two decades of international research on one of the leading theoretical models of work stress research; effort-reward imbalance. Consisting of 3 parts and 8 sub-parts, this essential reference work deals with theory and methods, review of research evidence on health effects, new findings from Asia, Australia, and Latin America, and model extensions and interventions. This book has a selective theoretical focus, and the large majority of chapters is restricted to the meso-level of organizational research. With a combination of research evidence derived from macro-, meso- and micro-level investigations, the inclusion of a broad spectrum of material and psychosocial occupational stressors, and with its unique focus on socioeconomic determinants this handbook offers a valuable source of information to a broad audience interested in occupational health science. . |
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