1.

Record Nr.

UNINA9910483681203321

Titolo

Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Hans G. Vogel

Pubbl/distr/stampa

Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2002

ISBN

3-540-29837-1

Edizione

[2nd ed. 2002.]

Descrizione fisica

1 online resource (1643 p.)

Disciplina

615.10724

Soggetti

Pharmacology

Pharmacy

Biochemistry

Pharmacology/Toxicology

Biochemistry, general

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

""Preface to the first edition""; ""Contributors""; ""Contents""; ""Introduction Strategies in drug discovery and evaluation""; ""Chapter A Cardiovascular activity""; ""Chapter B Activity on blood constituents""; ""Chapter C Activity on urinary tract""; ""Chapter E Psychotropic and neurotropic activity""; ""Chapter F Drug effects on learning and memory""; ""Chapter G Effects on peripheral nerve function""; ""Chapter J Activity on the gastrointestinal tract""; ""Chapter K Antidiabetic activity""; ""Chapter M Anti- atherosclerotic activity""; ""Chapter N Endocrinology""

""Chapter Q Guidelines for the care and use of laboratory animals""""Index""

Sommario/riassunto

Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining



the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.