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1. |
Record Nr. |
UNINA9910437850803321 |
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Titolo |
Advances in biology and therapy of multiple myeloma . Volume 1 Basic science / / Nikhil C. Munshi, Kenneth C. Anderson, editors |
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Pubbl/distr/stampa |
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New York, : Springer, c2013 |
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ISBN |
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1-283-84894-5 |
1-4614-4666-X |
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Descrizione fisica |
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1 online resource (321 p.) |
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Altri autori (Persone) |
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MunshiNikhil C |
AndersonKenneth C |
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Disciplina |
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Soggetti |
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Bone marrow - Diseases |
Myelodysplastic syndromes |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Genomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index. |
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Sommario/riassunto |
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Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, |
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novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact. |
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2. |
Record Nr. |
UNINA9910483000603321 |
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Autore |
Grazioli Margherita |
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Titolo |
Housing, Urban Commons and the Right to the City in Post-Crisis Rome : Metropoliz, The Squatted Città Meticcia / / by Margherita Grazioli |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Palgrave Macmillan, , 2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (175 pages) |
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Disciplina |
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Soggetti |
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Ethnology |
Human geography |
Sociology, Urban |
Social structure |
Equality |
Sociocultural Anthropology |
Human Geography |
Ethnography |
Urban Sociology |
Social Structure |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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1. Introduction -- 2. Housing Squats, Urban Commons, Right to the City -- 3. The Activist Ethnographic Method -- 4. Rome, The Squatted City -- 5. Occupy Metropoliz -- 6. The Commoning and Eurythmization of the Città Meticcia -- 7. The Politics and Urban Commons of Metropoliz and the MAAM -- 8. Without Metropoliz, This Ain't My City!. |
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Sommario/riassunto |
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"Grazioli's nuanced and contextualised accounts of the 'housing squat' Metropoliz provide an illuminating discussion of the political value that concepts such as 'the right to the city' and 'urban commons' hold for contemporary anti-capitalist struggles." - Miguel A. Martínez, author of Squatters in the Capitalist City, Uppsala University, Sweden "As a precise and passionate analytical account of the ways in which mundane built environments can be repurposed for the engendering of inventive forms of collective life, this book is an essential guide. In an era that makes constant reference to the commons, Grazioli vividly shows us just what such a commons concretely might be." - AbdouMaliq Simone, Urban Institute - University of Sheffield, UK "With her beautiful and powerful prose, Grazioli not only offers a grounded analysis of the meaning and makings of liberatory forms of housing, but she also shows what it means to researchspaces like Metropoliz embodying and reverberating their broader urban politics. This book is a quintessential read for anyone concerned with the future of cities well beyond Rome." - Michele Lancione, Urban Institute - University of Sheffield, UK This book tells the story of Metropoliz, a vacant salami factory located in the Eastern periphery of Rome (Italy) that was squatted in 2009 by homeless households with the cooperation of the Housing Rights Movement Blocchi Precari Metropolitani, and progressively reconverted into the house and museum spaces that form the Città Meticcia (the mestizo city). Through a vivid activist-ethnographic account, Margherita Grazioli suggests that Metropoliz exemplifies a practice of grassroots urban regeneration that speaks to the conflicted reconfiguration of real estate urban regimes in a post-crisis, post-neoliberal scenario. Using the contentious reappropriation of housing as a point of departure for claiming manifold rights, Metropoliz represents an alternative model of urbanity and habitation that will inspire contemporary urban social movements concerned with the demand of the 'right to the city', as well as those concerned with the ontology of the urban commons. Margherita Grazioli is Postdoctoral Research Fellow in Regional Sciences & Economic Geography at the Social Sciences Area of the Gran Sasso Science Institute in L'Aquila, Italy. |
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