| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910465750003321 |
|
|
Autore |
Fallis George <1947-> |
|
|
Titolo |
Rethinking higher education : participation, research, and differentiation / / George Fallis |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Montreal, [Quebec] : , : McGill-Queen's University Press, , 2013 |
|
©2013 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-55339-334-1 |
1-55339-342-2 |
|
|
|
|
|
|
|
|
Edizione |
[20160314th ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (273 p.) |
|
|
|
|
|
|
Collana |
|
Queen's Policy Studies Series |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Education, Higher - Ontario |
Universities and colleges - Ontario |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Introduction -- 1. Ontario's System of Higher Education -- 2. Institutional Differentiation: Mandate and Programs -- 3. Government Policy, Institutional Decision Making, and Isomorphism -- 4. Participation: Universal Higher Education Has Been Achieved -- 5. Rethinking Baccalaureate Education -- 6. Graduate Education and Professional Education -- 7. The New Research Agenda -- 8. Rethinking University Research -- 9. Further Differentiation of the Binary System -- 10. Conclusion: Policy Directions and Implementation -- Epilogue: Higher Education Policy in a Time of Expenditure Restraint. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
The basic structure of universities and colleges in Ontario - one focused primarily on expansion and greater access and put in place in the 1960's - is outdated. The system is now large enough, the eligible age group for entering post-secondary studies is shrinking, and participation rates are as high as they are likely to go. In Rethinking Higher Education, George Fallis argues that policy-makers should shift their attention away from growth and towards improving and diversifying the range of programs available and creating new means of program delivery. He calls for increases in honours undergraduate programs and polytechnic education and envisions a group of |
|
|
|
|
|
|
|
|
|
|
|
|
|
research-intensive universities responsible for doctoral education. The existing design, Fallis contends, neglects the specific needs of graduate education and research, layering it on top of a system designed for undergraduate education. In addition, there is disconnection between Ontario's Ministry of Training, Colleges, and Universities and the research missions of the universities and colleges themselves. Fallis recommends that Ontario establish a system for documenting and assessing the quality of research published at universities. Thought-provoking and thoroughly argued, Rethinking Higher Education provides a detailed design for higher education in the twenty-first century. |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910141488903321 |
|
|
Autore |
Phoenix David A |
|
|
Titolo |
Antimicrobial peptides [[electronic resource] /] / David A. Phoenix, Sarah R. Dennison, and Frederick Harris |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, : Wiley-VCH, c2013 |
|
|
|
|
|
|
|
ISBN |
|
3-527-65285-X |
3-527-65287-6 |
1-299-15730-0 |
3-527-65288-4 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (254 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
DennisonSarah R |
HarrisFrederick |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Cover; Related Titles; Title page; Copyright page; Contents; Preface; References; List of Abbreviations; 1: Antimicrobial Peptides: Their History, Evolution, and Functional Promiscuity; Summary; 1.1 Introduction: The History of Antimicrobial Peptides; 1.2 AMPs: Evolutionarily Ancient Molecules; 1.3 AMPs: Multifunctional Molecules; |
|
|
|
|
|
|
|
|
|
|
|
1.3.1 Defensins as Effectors of Immunity; 1.3.2 Defensins and Wound Healing; 1.3.3 Defensins and Canine Coat Color; 1.4 Discussion; References; 2: Cationic Antimicrobial Peptides; Summary; 2.1 Introduction; 2.2 CAMPs and Their Antimicrobial Action |
2.3 CAMPs That Adopt an α-Helical Structure2.4 CAMPs That Adopt a β-Sheet Structure; 2.5 CAMPs That Adopt Extended Structures Rich in Specific Residues; 2.6 Discussion; References; 3: Anionic Antimicrobial Peptides; Summary; 3.1 Introduction; 3.2 AAMPs in the Respiratory Tract; 3.3 AAMPs in the Brain; 3.4 AAMPs in the Epidermis; 3.5 AAMPs in the Epididymis; 3.6 AAMPs in Blood Components; 3.7 AAMPs in the Gastrointestinal Tract and Food Proteins; 3.8 AAMPs and Their Structure-Function Relationships; 3.9 Discussion; References |
4: Graphical Techniques to Visualize the Amphiphilic Structures of Antimicrobial PeptidesSummary; 4.1 Introduction; 4.2 Amphiphilic Structures Adopted by AMPs; 4.3 Qualitative Methods for Identifying Amphiphilic Structure; 4.4 Quantitative Techniques for Analyzing Amphiphilic Structure; 4.4.1 Techniques Based on Hydropathy Plot Analysis; 4.4.2 Techniques Based on Fourier Transforms; 4.4.3 Amphipathic Index; 4.4.4 Hydrophobic Moment Analysis; 4.4.5 Classification of Amphiphilic α-Helices Using the Approach of Segrest; 4.4.6 Amphiphilicity Profiling Analysis of Tilted α-Helices |
4.4.7 Extended Hydrophobic Moment Plot Analysis of Tilted α-Helices4.4.8 Amphiphilicity Quantified Using the Approach of Keller; 4.4.9 Amphiphilicity Quantified Using the Approach of Brasseur; 4.5 Discussion; References; 5: Models for the Membrane Interactions of Antimicrobial Peptides; Summary; 5.1 Introduction; 5.2 CM-Associated Factors That Affect the Antimicrobial Action of α-CAMPs; 5.3 Mechanisms Used by CAMPs for Microbial Membrane Interaction; 5.4 Established Models for the Membrane Interactions of α-AMPs; 5.4.1 Barrel-Stave and Toroidal Pore Models |
5.4.2 Carpet Mechanism and the Shai-Huang-Matsazuki Model5.5 Recent Novel Models for the Membrane Interactions of α-AMPs; 5.6 Tilted Peptide Mechanism; 5.7 Amyloidogenic Mechanisms; 5.8 Discussion; References; 6: Selectivity and Toxicity of Oncolytic Antimicrobial Peptides; Summary; 6.1 Introduction; 6.2 Peptide-Based Factors That Contribute to the Anticancer Action of Anticancer Peptides; 6.2.1 Sequence Length; 6.2.2 Net Positive Charge; 6.2.3 Hydrophobicity; 6.2.4 Amphiphilicity; 6.3 Membrane-Based Factors That Contribute to the Anticancer Action of ACPs; 6.3.1 Membrane Receptors |
6.3.2 Cholesterol |
|
|
|
|
|
|
Sommario/riassunto |
|
In this didactically-written text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers.The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application by discussing their design principles, target membranes and structure-activity relationship |
|
|
|
|
|
|
|
| |