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Record Nr. |
UNINA9910464688803321 |
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Titolo |
Extracellular matrix [[electronic resource] ] : pathobiology and signaling / / edited by Nikos K. Karamanos |
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Pubbl/distr/stampa |
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Berlin, : Walter de Gruyter, c2012 |
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ISBN |
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1-283-62774-4 |
3-11-025877-3 |
9786613940193 |
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Descrizione fisica |
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1 online resource (940 p.) |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Extracellular matrix |
Cellular signal transduction |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis ... [et al.] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. |
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Sommario/riassunto |
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Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.It will provide an introduction to the extracellular matrix and detailed sections and |
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chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden |
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting. |
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2. |
Record Nr. |
UNISALENTO991003553879707536 |
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Autore |
Ciullini, Antonella |
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Titolo |
Calcolo integrale : esercizi / Antonella Ciullini |
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Pubbl/distr/stampa |
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Milano : CittàStudi, 1991 |
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Descrizione fisica |
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Classificazione |
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Disciplina |
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Soggetti |
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Calculus, integral - Problems, exercices, etc |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910821803803321 |
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Autore |
Gunkel Lutz |
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Titolo |
Grammatik des Deutschen im europäischen Vergleich . Teilband 1 Funktionale Domänen, Wort und Wortklassen : das Nominal / / Lutz Gunkel [and four others] ; unter Mitarbeit von Christine Günther und Ursula Hoberg |
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Pubbl/distr/stampa |
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Berlin, [Germany] ; ; Boston, [Massachusetts] : , : De Gruyter, , 2017 |
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©2017 |
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ISBN |
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3-11-039535-5 |
3-11-034146-8 |
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Edizione |
[2 Bd., 2004 S. inges.] |
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Descrizione fisica |
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1 online resource (1,974 pages) |
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Collana |
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Schriften des Instituts für Deutsche Sprache, , 1861-566X ; ; Band 14.1 |
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Classificazione |
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Disciplina |
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Soggetti |
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German language - Noun |
German language - Grammar, Comparative |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Frontmatter -- Vorwort -- Inhaltsübersicht -- Verzeichnis der Abkürzungen -- Verzeichnis der Sprachsiglen -- Verzeichnis der Symbole -- Einleitung -- A. Funktionale Domänen -- B1.1 Überblick -- B1.2 Artikel und Demonstrativa -- B1.3 Adjektive -- B1.4 Substantive -- B1.5 Pronomina -- B2.1 Überblick -- B2.2 Genus -- B2.3 Numerus -- B2.4 Kasus -- C. Nominalflexion -- D1. Syntax der Nominalphrase -- D2. Nominalphrasen mit adjektivischem oder partizipialem Kopf -- D3. Possessive Attribute -- D4. Nicht-possessive PP- und NP-Attribute -- D5. Numerativkonstruktionen -- D6. Relativsyntagmen -- D7. Partizipialattribute -- Inhaltsverzeichnis -- Quellenverzeichnis -- Literaturverzeichnis -- Register |
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Sommario/riassunto |
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Das Deutsche gehört zu den besonders gut erforschten Sprachen der Welt. Neue Erkenntnisse über seine Grammatik sind am ehesten durch eine Ausweitung der Perspektive über den traditionellen Ansatz hinaus zu erwarten. Im vorliegenden Handbuch zur Nominalgrammatik geschieht dies auf dem Weg des Sprachvergleichs mit anderen europäischen Sprachen, in erster Linie den Kontrastsprachen Englisch, Französisch, Polnisch und Ungarisch. Die Grammatik schließt an die typologische Forschung an und orientiert den Vergleich an allgemeinen semantisch-pragmatischen Funktionsbereichen, so genannten ,funktionalen Domänen‘ wie Referenz, Identifikation, Modifikation. Behandelt werden nominale Wortklassen (wie Substantiv, Adjektiv, Pronomen), das nominale Klassifikationssystem (mit Genus, Numerus und Kasus), die nominale Flexionsmorphologie sowie nominale Syntagmen mit dem Schwerpunkt der NP-Syntax. Der Vergleich stellt die Optionen im Vergleichsspektrum heraus, von denen das Deutsche Gebrauch macht, zeigt aber auch, welche Möglichkeiten nicht realisiert sind, und lässt somit das typologische Profil dieser Sprache im Detail erkennen. |
This functionally oriented contrastive grammar is devoted to nominal word classes (such as nouns, adjectives, and pronouns), their classification (such as gender, case, and number), nominal inflectional morphology, and nominal syntagms, especially the syntax of the nominal phrase. The descriptive focus is on German, and the principal contrastive languages are English, French, Polish, and Hungarian. |
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